rs12912251

Homo sapiens
G>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0241 (7233/29944,GnomAD)
T=0237 (6917/29118,TOPMED)
T=0184 (920/5008,1000G)
T=0311 (1199/3854,ALSPAC)
T=0316 (1172/3708,TWINSUK)
chr15:38694167 (GRCh38.p7) (15q14)
AD
GWASdb2
3   publication(s)
See rs on genome
8 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 15NC_000015.10:g.38694167G>T
GRCh37.p13 chr 15NC_000015.9:g.38986368G>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.860T=0.140
1000GenomesAmericanSub694G=0.750T=0.250
1000GenomesEast AsianSub1008G=0.900T=0.100
1000GenomesEuropeSub1006G=0.738T=0.262
1000GenomesGlobalStudy-wide5008G=0.816T=0.184
1000GenomesSouth AsianSub978G=0.800T=0.200
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.689T=0.311
The Genome Aggregation DatabaseAfricanSub8714G=0.828T=0.172
The Genome Aggregation DatabaseAmericanSub838G=0.740T=0.260
The Genome Aggregation DatabaseEast AsianSub1622G=0.909T=0.091
The Genome Aggregation DatabaseEuropeSub18468G=0.713T=0.286
The Genome Aggregation DatabaseGlobalStudy-wide29944G=0.758T=0.241
The Genome Aggregation DatabaseOtherSub302G=0.730T=0.270
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.762T=0.237
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.684T=0.316
PMID Title Author Journal
26044620Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction.Reyes-Gibby CCBMC Syst Biol
21926972Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.-Nat Genet
23089632A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53.Wang JCMol Psychiatry

P-Value

SNP ID p-value Traits Study
rs129122514.56E-08alcohol dependence23089632

eQTL of rs12912251 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs12912251 in Fetal Brain

Probe ID Position Gene beta p-value
cg21039679chr15:38989738C15orf53-0.02688447685059417.6028e-16

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr153896065238961725E068-24643
chr153896065238961725E069-24643
chr153896065238961725E070-24643
chr153894079638940926E071-45442
chr153900002839001434E08113660
chr153900646639007349E08120098
chr153896051838960573E082-25795
chr153896065238961725E082-24643