rs12956327

Homo sapiens
G>C / G>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0147 (4429/29952,GnomAD)
T=0124 (3633/29118,TOPMED)
T=0141 (705/5008,1000G)
T=0195 (753/3854,ALSPAC)
T=0187 (693/3708,TWINSUK)
chr18:74394359 (GRCh38.p7) (18q22.3)
CD
GWASdb2
1   publication(s)
See rs on genome
0 Enhancer around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 18NC_000018.10:g.74394359G>C
GRCh38.p7 chr 18NC_000018.10:g.74394359G>T
GRCh37.p13 chr 18NC_000018.9:g.72061594G>C
GRCh37.p13 chr 18NC_000018.9:g.72061594G>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.962T=0.038
1000GenomesAmericanSub694G=0.820T=0.180
1000GenomesEast AsianSub1008G=0.757T=0.243
1000GenomesEuropeSub1006G=0.807T=0.193
1000GenomesGlobalStudy-wide5008G=0.859T=0.141
1000GenomesSouth AsianSub978G=0.910T=0.090
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.805T=0.195
The Genome Aggregation DatabaseAfricanSub8720G=0.938C=0.000
The Genome Aggregation DatabaseAmericanSub838G=0.800C=0.00,
The Genome Aggregation DatabaseEast AsianSub1618G=0.779C=0.000
The Genome Aggregation DatabaseEuropeSub18474G=0.821C=0.000
The Genome Aggregation DatabaseGlobalStudy-wide29952G=0.852C=0.000
The Genome Aggregation DatabaseOtherSub302G=0.780C=0.00,
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.875T=0.124
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.813T=0.187
PMID Title Author Journal
23958962Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.Gelernter JMol Psychiatry

P-Value

SNP ID p-value Traits Study
rs129563271.57E-05cocaine dependence23958962

eQTL of rs12956327 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs12956327 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.