rs13146963

Homo sapiens
A>G
LARP7 : Intron Variant
ZGRF1 : 2KB Upstream Variant
Check p-value
SNV (Single Nucleotide Variation)
A==0411 (12306/29922,GnomAD)
A==0396 (11535/29118,TOPMED)
A==0277 (1387/5008,1000G)
A==0435 (1676/3854,ALSPAC)
A==0417 (1548/3708,TWINSUK)
chr4:112637446 (GRCh38.p7) (4q25)
AD
GWASdb2
1   publication(s)
See rs on genome
8 Enhancers around
10 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.112637446A>G
GRCh37.p13 chr 4NC_000004.11:g.113558602A>G
LARP7 RefSeqGeneNG_032779.1:g.5483A>G

Gene: LARP7, La ribonucleoprotein domain family member 7(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LARP7 transcript variant 3NM_001267039.1:c.N/AIntron Variant
LARP7 transcript variant 1NM_016648.3:c.N/AIntron Variant
LARP7 transcript variant 2NM_015454.2:c.N/AGenic Upstream Transcript Variant
LARP7 transcript variant 4NR_049768.1:n.N/AIntron Variant

Gene: ZGRF1, zinc finger GRF-type containing 1(minus strand): 2KB Upstream Variant

Molecule type Change Amino acid[Codon] SO Term
ZGRF1 transcript variant 1NM_018392.4:c.N/AUpstream Transcript Variant
ZGRF1 transcript variant X1XM_005263115.3:c.N/AUpstream Transcript Variant
ZGRF1 transcript variant X2XM_011532091.2:c.N/AUpstream Transcript Variant
ZGRF1 transcript variant X3XM_011532092.2:c.N/AUpstream Transcript Variant
ZGRF1 transcript variant X5XM_011532093.2:c.N/AUpstream Transcript Variant
ZGRF1 transcript variant X6XM_011532094.2:c.N/AUpstream Transcript Variant
ZGRF1 transcript variant X11XM_011532096.2:c.N/AUpstream Transcript Variant
ZGRF1 transcript variant X4XM_017008369.1:c.N/AUpstream Transcript Variant
ZGRF1 transcript variant X5XM_017008370.1:c.N/AUpstream Transcript Variant
ZGRF1 transcript variant X7XM_017008371.1:c.N/AUpstream Transcript Variant
ZGRF1 transcript variant X15XM_017008372.1:c.N/AUpstream Transcript Variant
ZGRF1 transcript variant X16XM_017008373.1:c.N/AUpstream Transcript Variant
ZGRF1 transcript variant X12XM_011532097.2:c.N/AN/A
ZGRF1 transcript variant X13XM_011532098.2:c.N/AN/A
ZGRF1 transcript variant X14XM_011532099.2:c.N/AN/A
ZGRF1 transcript variant X10XR_001741282.1:n.N/AUpstream Transcript Variant
ZGRF1 transcript variant X8XR_938763.1:n.N/AUpstream Transcript Variant
ZGRF1 transcript variant X9XR_938764.1:n.N/AUpstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.387G=0.613
1000GenomesAmericanSub694A=0.260G=0.740
1000GenomesEast AsianSub1008A=0.059G=0.941
1000GenomesEuropeSub1006A=0.436G=0.564
1000GenomesGlobalStudy-wide5008A=0.277G=0.723
1000GenomesSouth AsianSub978A=0.200G=0.800
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.435G=0.565
The Genome Aggregation DatabaseAfricanSub8724A=0.393G=0.607
The Genome Aggregation DatabaseAmericanSub836A=0.260G=0.740
The Genome Aggregation DatabaseEast AsianSub1620A=0.049G=0.951
The Genome Aggregation DatabaseEuropeSub18442A=0.457G=0.542
The Genome Aggregation DatabaseGlobalStudy-wide29922A=0.411G=0.588
The Genome Aggregation DatabaseOtherSub300A=0.470G=0.530
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.396G=0.603
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.417G=0.583
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs131469630.000448alcohol dependence20201924

eQTL of rs13146963 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr4:113558602LARP7ENSG00000174720.11A>G2.1704e-3456Cerebellar_Hemisphere

meQTL of rs13146963 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr4113559778113559852E0671176
chr4113559778113559852E0681176
chr4113559778113559852E0691176
chr4113559778113559852E0701176
chr4113559778113559852E0711176
chr4113554586113554987E072-3615
chr4113559778113559852E0741176
chr4113559778113559852E0811176








Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr4113557633113559114E0670
chr4113557633113559114E0680
chr4113557633113559114E0690
chr4113557633113559114E0700
chr4113557633113559114E0710
chr4113557633113559114E0720
chr4113557633113559114E0730
chr4113557633113559114E0740
chr4113557633113559114E0810
chr4113557633113559114E0820