rs1321687

Homo sapiens
C>A
None
Check p-value
SNV (Single Nucleotide Variation)
A=0406 (12158/29918,GnomAD)
A=0381 (11098/29118,TOPMED)
A=0303 (1517/5008,1000G)
C==0495 (1907/3854,ALSPAC)
C==0489 (1814/3708,TWINSUK)
chr1:86508351 (GRCh38.p7) (1p22.3)
ND
GWASdb2
1   publication(s)
See rs on genome
26 Enhancers around
2 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 1NC_000001.11:g.86508351C>A
GRCh37.p13 chr 1NC_000001.10:g.86974034C>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.818A=0.182
1000GenomesAmericanSub694C=0.590A=0.410
1000GenomesEast AsianSub1008C=0.843A=0.157
1000GenomesEuropeSub1006C=0.513A=0.487
1000GenomesGlobalStudy-wide5008C=0.697A=0.303
1000GenomesSouth AsianSub978C=0.650A=0.350
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.495A=0.505
The Genome Aggregation DatabaseAfricanSub8708C=0.768A=0.232
The Genome Aggregation DatabaseAmericanSub836C=0.550A=0.450
The Genome Aggregation DatabaseEast AsianSub1614C=0.851A=0.149
The Genome Aggregation DatabaseEuropeSub18462C=0.490A=0.509
The Genome Aggregation DatabaseGlobalStudy-wide29918C=0.593A=0.406
The Genome Aggregation DatabaseOtherSub298C=0.650A=0.350
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.618A=0.381
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.489A=0.511
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs13216870.000959nicotine dependence17158188

eQTL of rs1321687 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1321687 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr18695235786953713E067-20321
chr18696679286966896E067-7138
chr18697042386970632E067-3402
chr18697068386971396E067-2638
chr18695235786953713E068-20321
chr18697042386970632E068-3402
chr18697068386971396E068-2638
chr18701448087015091E06840446
chr18694109086941147E069-32887
chr18697042386970632E069-3402
chr18697068386971396E069-2638
chr18701448087015091E06940446
chr18697068386971396E070-2638
chr18695235786953713E071-20321
chr18697005586970139E071-3895
chr18697042386970632E071-3402
chr18697068386971396E071-2638
chr18697068386971396E072-2638
chr18701448087015091E07240446
chr18694109086941147E074-32887
chr18697005586970139E074-3895
chr18697042386970632E074-3402
chr18697068386971396E074-2638
chr18701448087015091E07440446
chr18697042386970632E082-3402
chr18697068386971396E082-2638








Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr18696786986968323E068-5711
chr18696786986968323E072-5711