rs13277254

Homo sapiens
G>A
None
Check p-value
SNV (Single Nucleotide Variation)
G==0334 (10025/29960,GnomAD)
G==0401 (11702/29118,TOPMED)
G==0354 (1773/5008,1000G)
G==0223 (861/3854,ALSPAC)
G==0232 (859/3708,TWINSUK)
chr8:42694839 (GRCh38.p7) (8p11.21)
ND
GWASdb2
20   publication(s)
See rs on genome
28 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.42694839G>A
GRCh37.p13 chr 8NC_000008.10:g.42549982G>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.657A=0.343
1000GenomesAmericanSub694G=0.300A=0.700
1000GenomesEast AsianSub1008G=0.204A=0.796
1000GenomesEuropeSub1006G=0.225A=0.775
1000GenomesGlobalStudy-wide5008G=0.354A=0.646
1000GenomesSouth AsianSub978G=0.270A=0.730
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.223A=0.777
The Genome Aggregation DatabaseAfricanSub8710G=0.604A=0.396
The Genome Aggregation DatabaseAmericanSub838G=0.240A=0.760
The Genome Aggregation DatabaseEast AsianSub1620G=0.184A=0.816
The Genome Aggregation DatabaseEuropeSub18490G=0.226A=0.773
The Genome Aggregation DatabaseGlobalStudy-wide29960G=0.334A=0.665
The Genome Aggregation DatabaseOtherSub302G=0.260A=0.740
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.401A=0.598
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.232A=0.768
PMID Title Author Journal
25036316Joint association of nicotinic acetylcholine receptor variants with abdominal obesity in American Indians: the Strong Heart Family Study.Zhu YPLoS One
19492010The genetic components of alcohol and nicotine co-addiction: from genes to behavior.Schlaepfer IRCurr Drug Abuse Rev
20418888Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior.Thorgeirsson TENat Genet
17135278Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs.Saccone SFHum Mol Genet
21606948Varenicline for smoking cessation: nausea severity and variation in nicotinic receptor genes.Swan GEPharmacogenomics J
20736995Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerstrom test for nicotine dependence.Wessel JNeuropsychopharmacology
20584212Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.Saccone NLGenes Brain Behav
27827986Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence.Zuo LGenes (Basel)
27166759Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions.Yang JMol Psychiatry
26318101The beta3 subunit of the nicotinic acetylcholine receptor: Modulation of gene expression and nicotine consumption.Kamens HMNeuropharmacology
19760673Association of CHRN genes with "dizziness" to tobacco.Ehringer MAAm J Med Genet B Neuropsychiatr Genet
27327258Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research.Wen LTransl Psychiatry
21191315Genetic association of bipolar disorder with the beta(3) nicotinic receptor subunit gene.Hartz SMPsychiatr Genet
19029397Nicotinic receptor gene variants influence susceptibility to heavy smoking.Stevens VLCancer Epidemiol Biomarkers Prev
21079997Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence.Culverhouse RCHum Genet
23691092Associations of prenatal nicotine exposure and the dopamine related genes ANKK1 and DRD2 to verbal language.Eicher JDPLoS One
20840187Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence.Johnson EOAddiction
18571741Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research.Portugal GSBehav Brain Res
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet
19259974Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.Saccone NLAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs132772546.54E-05nicotine dependence17158188

eQTL of rs13277254 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs13277254 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr84255878642559348E0678804
chr84255950742559557E0679525
chr84255956442559738E0679582
chr84255978342560036E0679801
chr84257551642576584E06925534
chr84255878642559348E0718804
chr84255950742559557E0719525
chr84255956442559738E0719582
chr84257551642576584E07125534
chr84259581842596743E07145836
chr84259678542596841E07146803
chr84254736742548251E072-1731
chr84257551642576584E07225534
chr84259581842596743E07245836
chr84257551642576584E07325534
chr84255878642559348E0748804
chr84255950742559557E0749525
chr84255956442559738E0749582
chr84255978342560036E0749801
chr84256031142560370E07410329
chr84257551642576584E07425534
chr84259678542596841E07446803
chr84259699542597311E07447013
chr84251152842512118E081-37864
chr84256031142560370E08110329
chr84256054542560595E08110563
chr84256060442560725E08110622
chr84259699542597311E08147013