rs13277524

Homo sapiens
G>T
None
Check p-value
SNV (Single Nucleotide Variation)
G==0361 (10805/29934,GnomAD)
G==0439 (12809/29118,TOPMED)
G==0380 (1905/5008,1000G)
G==0224 (863/3854,ALSPAC)
G==0232 (861/3708,TWINSUK)
chr8:42694914 (GRCh38.p7) (8p11.21)
ND
GWASdb2
8   publication(s)
See rs on genome
28 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.42694914G>T
GRCh37.p13 chr 8NC_000008.10:g.42550057G>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.753T=0.247
1000GenomesAmericanSub694G=0.300T=0.700
1000GenomesEast AsianSub1008G=0.204T=0.796
1000GenomesEuropeSub1006G=0.224T=0.776
1000GenomesGlobalStudy-wide5008G=0.380T=0.620
1000GenomesSouth AsianSub978G=0.270T=0.730
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.224T=0.776
The Genome Aggregation DatabaseAfricanSub8700G=0.693T=0.307
The Genome Aggregation DatabaseAmericanSub836G=0.250T=0.750
The Genome Aggregation DatabaseEast AsianSub1620G=0.184T=0.816
The Genome Aggregation DatabaseEuropeSub18476G=0.226T=0.773
The Genome Aggregation DatabaseGlobalStudy-wide29934G=0.361T=0.639
The Genome Aggregation DatabaseOtherSub302G=0.260T=0.740
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.439T=0.560
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.232T=0.768
PMID Title Author Journal
21606948Varenicline for smoking cessation: nausea severity and variation in nicotinic receptor genes.Swan GEPharmacogenomics J
20584212Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.Saccone NLGenes Brain Behav
27827986Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence.Zuo LGenes (Basel)
19760673Association of CHRN genes with "dizziness" to tobacco.Ehringer MAAm J Med Genet B Neuropsychiatr Genet
27327258Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research.Wen LTransl Psychiatry
21191315Genetic association of bipolar disorder with the beta(3) nicotinic receptor subunit gene.Hartz SMPsychiatr Genet
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet
21079997Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence.Culverhouse RCHum Genet

P-Value

SNP ID p-value Traits Study
rs132775240.000114nicotine dependence17158188

eQTL of rs13277524 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs13277524 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr84255878642559348E0678729
chr84255950742559557E0679450
chr84255956442559738E0679507
chr84255978342560036E0679726
chr84257551642576584E06925459
chr84255878642559348E0718729
chr84255950742559557E0719450
chr84255956442559738E0719507
chr84257551642576584E07125459
chr84259581842596743E07145761
chr84259678542596841E07146728
chr84254736742548251E072-1806
chr84257551642576584E07225459
chr84259581842596743E07245761
chr84257551642576584E07325459
chr84255878642559348E0748729
chr84255950742559557E0749450
chr84255956442559738E0749507
chr84255978342560036E0749726
chr84256031142560370E07410254
chr84257551642576584E07425459
chr84259678542596841E07446728
chr84259699542597311E07446938
chr84251152842512118E081-37939
chr84256031142560370E08110254
chr84256054542560595E08110488
chr84256060442560725E08110547
chr84259699542597311E08146938