rs13331869

Homo sapiens
T>A
FTO : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0206 (6172/29944,GnomAD)
A=0279 (1395/5008,1000G)
A=0138 (533/3854,ALSPAC)
A=0139 (517/3708,TWINSUK)
chr16:54032082 (GRCh38.p7) (16q12.2)
ND
GWASdb2
2   publication(s)
See rs on genome
102 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 16NC_000016.10:g.54032082T>A
GRCh37.p13 chr 16NC_000016.9:g.54065994T>A
FTO RefSeqGeneNG_012969.1:g.333120T>A

Gene: FTO, fat mass and obesity associated(plus strand)

Molecule type Change Amino acid[Codon] SO Term
FTO transcriptNM_001080432.2:c.N/AIntron Variant
FTO transcript variant X1XM_011523313.2:c.N/AIntron Variant
FTO transcript variant X4XM_011523314.2:c.N/AGenic Downstream Transcript Variant
FTO transcript variant X5XM_011523315.2:c.N/AGenic Downstream Transcript Variant
FTO transcript variant X6XM_011523316.2:c.N/AGenic Downstream Transcript Variant
FTO transcript variant X2XM_017023654.1:c.N/AGenic Downstream Transcript Variant
FTO transcript variant X3XM_017023655.1:c.N/AGenic Downstream Transcript Variant
FTO transcript variant X7XM_017023656.1:c.N/AGenic Downstream Transcript Variant
FTO transcript variant X8XM_017023657.1:c.N/AGenic Downstream Transcript Variant
FTO transcript variant X9XM_017023658.1:c.N/AGenic Downstream Transcript Variant
FTO transcript variant X10XR_001751980.1:n.N/AGenic Downstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.536A=0.464
1000GenomesAmericanSub694T=0.840A=0.160
1000GenomesEast AsianSub1008T=0.840A=0.160
1000GenomesEuropeSub1006T=0.851A=0.149
1000GenomesGlobalStudy-wide5008T=0.721A=0.279
1000GenomesSouth AsianSub978T=0.630A=0.370
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.862A=0.138
The Genome Aggregation DatabaseAfricanSub8704T=0.598A=0.402
The Genome Aggregation DatabaseAmericanSub838T=0.880A=0.120
The Genome Aggregation DatabaseEast AsianSub1616T=0.832A=0.168
The Genome Aggregation DatabaseEuropeSub18484T=0.878A=0.121
The Genome Aggregation DatabaseGlobalStudy-wide29944T=0.793A=0.206
The Genome Aggregation DatabaseOtherSub302T=0.830A=0.170
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.861A=0.139
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet
18487448Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population.Chang YCDiabetes

P-Value

SNP ID p-value Traits Study
rs133318690.000334nicotine dependence17158188

eQTL of rs13331869 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs13331869 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr165402504054026305E067-39689
chr165404155654041632E067-24362
chr165404167854041732E067-24262
chr165404175054041902E067-24092
chr165408800954088210E06722015
chr165408825254088668E06722258
chr165408879854088960E06722804
chr165409629254096695E06730298
chr165402019654020382E068-45612
chr165402504054026305E068-39689
chr165406015454060211E068-5783
chr165406050754060605E068-5389
chr165406093754060991E068-5003
chr165406112854061333E068-4661
chr165407229354072376E0686299
chr165407238154072473E0686387
chr165408781454087913E06821820
chr165408800954088210E06822015
chr165408825254088668E06822258
chr165408879854088960E06822804
chr165409671854097712E06830724
chr165402504054026305E069-39689
chr165402640954026510E069-39484
chr165406050754060605E069-5389
chr165406093754060991E069-5003
chr165408800954088210E06922015
chr165408825254088668E06922258
chr165401959054019640E070-46354
chr165401969554019795E070-46199
chr165401991154020075E070-45919
chr165402019654020382E070-45612
chr165402061954020775E070-45219
chr165402088554021051E070-44943
chr165408305954084087E07017065
chr165408716254087257E07021168
chr165408736654087765E07021372
chr165408781454087913E07021820
chr165408800954088210E07022015
chr165408825254088668E07022258
chr165408879854088960E07022804
chr165402019654020382E071-45612
chr165402478654024970E071-41024
chr165402504054026305E071-39689
chr165402640954026510E071-39484
chr165404155654041632E071-24362
chr165404167854041732E071-24262
chr165404175054041902E071-24092
chr165406050754060605E071-5389
chr165406093754060991E071-5003
chr165406112854061333E071-4661
chr165406136054061470E071-4524
chr165406149154061678E071-4316
chr165408305954084087E07117065
chr165408825254088668E07122258
chr165408879854088960E07122804
chr165408904254089406E07123048
chr165408985354090053E07123859
chr165409019954090243E07124205
chr165409024454090324E07124250
chr165409318854093553E07127194
chr165409671854097712E07130724
chr165409775554097830E07131761
chr165402478654024970E072-41024
chr165402504054026305E072-39689
chr165402640954026510E072-39484
chr165408825254088668E07222258
chr165408879854088960E07222804
chr165409671854097712E07230724
chr165402504054026305E073-39689
chr165401656054016716E074-49278
chr165401685554016961E074-49033
chr165402504054026305E074-39689
chr165402640954026510E074-39484
chr165402671154026766E074-39228
chr165403363254033714E074-32280
chr165404155654041632E074-24362
chr165404167854041732E074-24262
chr165404175054041902E074-24092
chr165406136054061470E074-4524
chr165406149154061678E074-4316
chr165408305954084087E07417065
chr165408800954088210E07422015
chr165408825254088668E07422258
chr165408879854088960E07422804
chr165408904254089406E07423048
chr165409671854097712E07430724
chr165409775554097830E07431761
chr165410456354104994E07438569
chr165402019654020382E081-45612
chr165402061954020775E081-45219
chr165402088554021051E081-44943
chr165402504054026305E081-39689
chr165408800954088210E08122015
chr165401991154020075E082-45919
chr165402019654020382E082-45612
chr165402061954020775E082-45219
chr165406050754060605E082-5389
chr165406379454063844E082-2150
chr165408781454087913E08221820
chr165408879854088960E08222804
chr165410622254106519E08240228
chr165410656754106687E08240573