rs13334632

Organism: Homo sapiens

Alleles: T>C

Gene : Feature

ZCCHC14 : Intron Variant

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

C=0161 (4816/29904,GnomAD)
C=0150 (4387/29118,TOPMED)
C=0229 (1146/5008,1000G)
C=0138 (530/3854,ALSPAC)
C=0135 (502/3708,TWINSUK)

Position: chr16:87457213 (GRCh38.p7) (16q24.2)

Phenotype: ND

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 347 Enhancers around

Promoter: 45 Promoters around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 16	NC_000016.10:g.87457213T>C
GRCh37.p13 chr 16	NC_000016.9:g.87490819T>C

Gene: ZCCHC14, zinc finger CCHC-type containing 14(minus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
ZCCHC14 transcript	NM_015144.2:c.	N/A	Intron Variant
ZCCHC14 transcript variant X1	XM_005255858.3:c.	N/A	Intron Variant
ZCCHC14 transcript variant X4	XM_011522964.2:c.	N/A	Intron Variant
ZCCHC14 transcript variant X3	XM_017023082.1:c.	N/A	Intron Variant
ZCCHC14 transcript variant X2	XR_243401.3:n.	N/A	Intron Variant

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	T=0.886	C=0.114
1000Genomes	American	Sub	694	T=0.650	C=0.350
1000Genomes	East Asian	Sub	1008	T=0.536	C=0.464
1000Genomes	Europe	Sub	1006	T=0.860	C=0.140
1000Genomes	Global	Study-wide	5008	T=0.771	C=0.229
1000Genomes	South Asian	Sub	978	T=0.850	C=0.150
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	T=0.862	C=0.138
The Genome Aggregation Database	African	Sub	8700	T=0.879	C=0.121
The Genome Aggregation Database	American	Sub	836	T=0.640	C=0.360
The Genome Aggregation Database	East Asian	Sub	1618	T=0.543	C=0.457
The Genome Aggregation Database	Europe	Sub	18448	T=0.854	C=0.145
The Genome Aggregation Database	Global	Study-wide	29904	T=0.839	C=0.161
The Genome Aggregation Database	Other	Sub	302	T=0.840	C=0.160
Trans-Omics for Precision Medicine	Global	Study-wide	29118	T=0.849	C=0.150
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	T=0.865	C=0.135

PMID	Title	Author	Journal
22377092	ANAPC1 and SLCO3A1 are associated with nicotine dependence: meta-analysis of genome-wide association studies.	Wang KS	Drug Alcohol Depend

P-Value

SNP ID	p-value	Traits	Study
rs13334632	1.28E-05	nicotine dependence (smoking)	22377092

eQTL of rs13334632 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs13334632 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr16	87468266	87468306	E067	-22513
chr16	87468827	87468877	E067	-21942
chr16	87468933	87470319	E067	-20500
chr16	87470375	87470601	E067	-20218
chr16	87494647	87494702	E067	3828
chr16	87494728	87494891	E067	3909
chr16	87494927	87495666	E067	4108
chr16	87496707	87496808	E067	5888
chr16	87496885	87496935	E067	6066
chr16	87497015	87497069	E067	6196
chr16	87497357	87499382	E067	6538
chr16	87499503	87499877	E067	8684
chr16	87499913	87500113	E067	9094
chr16	87500224	87500472	E067	9405
chr16	87500504	87500620	E067	9685
chr16	87503405	87503556	E067	12586
chr16	87503940	87504017	E067	13121
chr16	87504028	87504110	E067	13209
chr16	87504114	87504232	E067	13295
chr16	87504294	87504388	E067	13475
chr16	87504855	87505216	E067	14036
chr16	87505233	87505591	E067	14414
chr16	87505701	87505786	E067	14882
chr16	87505965	87506043	E067	15146
chr16	87509312	87509634	E067	18493
chr16	87509648	87509725	E067	18829
chr16	87509735	87509872	E067	18916
chr16	87510929	87511529	E067	20110
chr16	87514546	87514606	E067	23727
chr16	87514649	87514699	E067	23830
chr16	87518629	87518708	E067	27810
chr16	87519327	87519367	E067	28508
chr16	87519424	87519590	E067	28605
chr16	87519645	87519742	E067	28826
chr16	87519790	87519831	E067	28971
chr16	87519959	87520035	E067	29140
chr16	87520047	87520148	E067	29228
chr16	87520334	87520459	E067	29515
chr16	87520489	87520775	E067	29670
chr16	87457706	87457756	E068	-33063
chr16	87458001	87458072	E068	-32747
chr16	87458074	87458218	E068	-32601
chr16	87458225	87458357	E068	-32462
chr16	87458387	87458437	E068	-32382
chr16	87458460	87458511	E068	-32308
chr16	87468827	87468877	E068	-21942
chr16	87468933	87470319	E068	-20500
chr16	87470375	87470601	E068	-20218
chr16	87494927	87495666	E068	4108
chr16	87497357	87499382	E068	6538
chr16	87499503	87499877	E068	8684
chr16	87499913	87500113	E068	9094
chr16	87502280	87502410	E068	11461
chr16	87502481	87502597	E068	11662
chr16	87502851	87502999	E068	12032
chr16	87503405	87503556	E068	12586
chr16	87504855	87505216	E068	14036
chr16	87505233	87505591	E068	14414
chr16	87505701	87505786	E068	14882
chr16	87505965	87506043	E068	15146
chr16	87506230	87506290	E068	15411
chr16	87509312	87509634	E068	18493
chr16	87509648	87509725	E068	18829
chr16	87509735	87509872	E068	18916
chr16	87510394	87510476	E068	19575
chr16	87510669	87510752	E068	19850
chr16	87510847	87510902	E068	20028
chr16	87510929	87511529	E068	20110
chr16	87511809	87511880	E068	20990
chr16	87514546	87514606	E068	23727
chr16	87514649	87514699	E068	23830
chr16	87514778	87514822	E068	23959
chr16	87517959	87518365	E068	27140
chr16	87518370	87518589	E068	27551
chr16	87518629	87518708	E068	27810
chr16	87518730	87518848	E068	27911
chr16	87519327	87519367	E068	28508
chr16	87519424	87519590	E068	28605
chr16	87519645	87519742	E068	28826
chr16	87519790	87519831	E068	28971
chr16	87519959	87520035	E068	29140
chr16	87520047	87520148	E068	29228
chr16	87520334	87520459	E068	29515
chr16	87521726	87521803	E068	30907
chr16	87521934	87521997	E068	31115
chr16	87522037	87522097	E068	31218
chr16	87458001	87458072	E069	-32747
chr16	87458074	87458218	E069	-32601
chr16	87458225	87458357	E069	-32462
chr16	87458387	87458437	E069	-32382
chr16	87460495	87460644	E069	-30175
chr16	87460656	87460759	E069	-30060
chr16	87460849	87461000	E069	-29819
chr16	87467380	87467445	E069	-23374
chr16	87468827	87468877	E069	-21942
chr16	87468933	87470319	E069	-20500
chr16	87470375	87470601	E069	-20218
chr16	87497357	87499382	E069	6538
chr16	87499503	87499877	E069	8684
chr16	87499913	87500113	E069	9094
chr16	87500224	87500472	E069	9405
chr16	87502851	87502999	E069	12032
chr16	87503405	87503556	E069	12586
chr16	87509312	87509634	E069	18493
chr16	87509648	87509725	E069	18829
chr16	87509735	87509872	E069	18916
chr16	87510929	87511529	E069	20110
chr16	87519424	87519590	E069	28605
chr16	87519645	87519742	E069	28826
chr16	87519790	87519831	E069	28971
chr16	87519959	87520035	E069	29140
chr16	87520047	87520148	E069	29228
chr16	87520334	87520459	E069	29515
chr16	87520489	87520775	E069	29670
chr16	87540385	87540456	E069	49566
chr16	87540482	87540596	E069	49663
chr16	87510847	87510902	E070	20028
chr16	87510929	87511529	E070	20110
chr16	87519959	87520035	E070	29140
chr16	87520047	87520148	E070	29228
chr16	87520334	87520459	E070	29515
chr16	87520489	87520775	E070	29670
chr16	87521934	87521997	E070	31115
chr16	87522426	87522486	E070	31607
chr16	87522612	87522874	E070	31793
chr16	87527621	87527759	E070	36802
chr16	87468266	87468306	E071	-22513
chr16	87468827	87468877	E071	-21942
chr16	87468933	87470319	E071	-20500
chr16	87470375	87470601	E071	-20218
chr16	87471042	87471118	E071	-19701
chr16	87494728	87494891	E071	3909
chr16	87494927	87495666	E071	4108
chr16	87497357	87499382	E071	6538
chr16	87499503	87499877	E071	8684
chr16	87499913	87500113	E071	9094
chr16	87500224	87500472	E071	9405
chr16	87502280	87502410	E071	11461
chr16	87502481	87502597	E071	11662
chr16	87502851	87502999	E071	12032
chr16	87503405	87503556	E071	12586
chr16	87503940	87504017	E071	13121
chr16	87504028	87504110	E071	13209
chr16	87504114	87504232	E071	13295
chr16	87504294	87504388	E071	13475
chr16	87504657	87504701	E071	13838
chr16	87504855	87505216	E071	14036
chr16	87505233	87505591	E071	14414
chr16	87505701	87505786	E071	14882
chr16	87505965	87506043	E071	15146
chr16	87508425	87508831	E071	17606
chr16	87509312	87509634	E071	18493
chr16	87509648	87509725	E071	18829
chr16	87509735	87509872	E071	18916
chr16	87510394	87510476	E071	19575
chr16	87510669	87510752	E071	19850
chr16	87510847	87510902	E071	20028
chr16	87514546	87514606	E071	23727
chr16	87514649	87514699	E071	23830
chr16	87514778	87514822	E071	23959
chr16	87514909	87514982	E071	24090
chr16	87517959	87518365	E071	27140
chr16	87518370	87518589	E071	27551
chr16	87519424	87519590	E071	28605
chr16	87519645	87519742	E071	28826
chr16	87519790	87519831	E071	28971
chr16	87519959	87520035	E071	29140
chr16	87520047	87520148	E071	29228
chr16	87520334	87520459	E071	29515
chr16	87520489	87520775	E071	29670
chr16	87521726	87521803	E071	30907
chr16	87521934	87521997	E071	31115
chr16	87522037	87522097	E071	31218
chr16	87522269	87522309	E071	31450
chr16	87522426	87522486	E071	31607
chr16	87522612	87522874	E071	31793
chr16	87446000	87446054	E072	-44765
chr16	87446106	87446165	E072	-44654
chr16	87446371	87446443	E072	-44376
chr16	87468266	87468306	E072	-22513
chr16	87468827	87468877	E072	-21942
chr16	87468933	87470319	E072	-20500
chr16	87494647	87494702	E072	3828
chr16	87494728	87494891	E072	3909
chr16	87494927	87495666	E072	4108
chr16	87497357	87499382	E072	6538
chr16	87499503	87499877	E072	8684
chr16	87499913	87500113	E072	9094
chr16	87500224	87500472	E072	9405
chr16	87500504	87500620	E072	9685
chr16	87500832	87501102	E072	10013
chr16	87501125	87501169	E072	10306
chr16	87502851	87502999	E072	12032
chr16	87503405	87503556	E072	12586
chr16	87503940	87504017	E072	13121
chr16	87504028	87504110	E072	13209
chr16	87509312	87509634	E072	18493
chr16	87509648	87509725	E072	18829
chr16	87509735	87509872	E072	18916
chr16	87510394	87510476	E072	19575
chr16	87510669	87510752	E072	19850
chr16	87510847	87510902	E072	20028
chr16	87510929	87511529	E072	20110
chr16	87514546	87514606	E072	23727
chr16	87514649	87514699	E072	23830
chr16	87514778	87514822	E072	23959
chr16	87519645	87519742	E072	28826
chr16	87519790	87519831	E072	28971
chr16	87519959	87520035	E072	29140
chr16	87520047	87520148	E072	29228
chr16	87520334	87520459	E072	29515
chr16	87520489	87520775	E072	29670
chr16	87445064	87445204	E073	-45615
chr16	87445316	87445366	E073	-45453
chr16	87445699	87445755	E073	-45064
chr16	87445797	87445855	E073	-44964
chr16	87446000	87446054	E073	-44765
chr16	87446106	87446165	E073	-44654
chr16	87458001	87458072	E073	-32747
chr16	87458074	87458218	E073	-32601
chr16	87458225	87458357	E073	-32462
chr16	87458387	87458437	E073	-32382
chr16	87458460	87458511	E073	-32308
chr16	87458776	87458826	E073	-31993
chr16	87460194	87460331	E073	-30488
chr16	87465154	87466019	E073	-24800
chr16	87466122	87466210	E073	-24609
chr16	87468266	87468306	E073	-22513
chr16	87468827	87468877	E073	-21942
chr16	87468933	87470319	E073	-20500
chr16	87470375	87470601	E073	-20218
chr16	87494647	87494702	E073	3828
chr16	87494728	87494891	E073	3909
chr16	87494927	87495666	E073	4108
chr16	87496707	87496808	E073	5888
chr16	87496885	87496935	E073	6066
chr16	87497015	87497069	E073	6196
chr16	87497357	87499382	E073	6538
chr16	87499503	87499877	E073	8684
chr16	87499913	87500113	E073	9094
chr16	87500224	87500472	E073	9405
chr16	87500504	87500620	E073	9685
chr16	87502280	87502410	E073	11461
chr16	87502481	87502597	E073	11662
chr16	87502851	87502999	E073	12032
chr16	87503405	87503556	E073	12586
chr16	87503940	87504017	E073	13121
chr16	87504028	87504110	E073	13209
chr16	87504114	87504232	E073	13295
chr16	87505233	87505591	E073	14414
chr16	87509312	87509634	E073	18493
chr16	87509648	87509725	E073	18829
chr16	87509735	87509872	E073	18916
chr16	87510394	87510476	E073	19575
chr16	87510669	87510752	E073	19850
chr16	87510847	87510902	E073	20028
chr16	87510929	87511529	E073	20110
chr16	87517844	87517898	E073	27025
chr16	87517959	87518365	E073	27140
chr16	87518370	87518589	E073	27551
chr16	87518629	87518708	E073	27810
chr16	87518730	87518848	E073	27911
chr16	87519327	87519367	E073	28508
chr16	87519424	87519590	E073	28605
chr16	87519645	87519742	E073	28826
chr16	87519790	87519831	E073	28971
chr16	87519959	87520035	E073	29140
chr16	87521726	87521803	E073	30907
chr16	87521934	87521997	E073	31115
chr16	87522037	87522097	E073	31218
chr16	87522269	87522309	E073	31450
chr16	87522426	87522486	E073	31607
chr16	87522612	87522874	E073	31793
chr16	87540385	87540456	E073	49566
chr16	87540482	87540596	E073	49663
chr16	87468827	87468877	E074	-21942
chr16	87468933	87470319	E074	-20500
chr16	87470375	87470601	E074	-20218
chr16	87497357	87499382	E074	6538
chr16	87499503	87499877	E074	8684
chr16	87499913	87500113	E074	9094
chr16	87500224	87500472	E074	9405
chr16	87500504	87500620	E074	9685
chr16	87509312	87509634	E074	18493
chr16	87509648	87509725	E074	18829
chr16	87509735	87509872	E074	18916
chr16	87510394	87510476	E074	19575
chr16	87510669	87510752	E074	19850
chr16	87510847	87510902	E074	20028
chr16	87510929	87511529	E074	20110
chr16	87517959	87518365	E074	27140
chr16	87518370	87518589	E074	27551
chr16	87519424	87519590	E074	28605
chr16	87519645	87519742	E074	28826
chr16	87519790	87519831	E074	28971
chr16	87519959	87520035	E074	29140
chr16	87520047	87520148	E074	29228
chr16	87520334	87520459	E074	29515
chr16	87520489	87520775	E074	29670
chr16	87521726	87521803	E074	30907
chr16	87521934	87521997	E074	31115
chr16	87522037	87522097	E074	31218
chr16	87522269	87522309	E074	31450
chr16	87522426	87522486	E074	31607
chr16	87522612	87522874	E074	31793
chr16	87540005	87540316	E074	49186
chr16	87540385	87540456	E074	49566
chr16	87540482	87540596	E074	49663
chr16	87488365	87488415	E081	-2404
chr16	87488467	87488511	E081	-2308
chr16	87488990	87489040	E081	-1779
chr16	87509312	87509634	E081	18493
chr16	87509648	87509725	E081	18829
chr16	87509735	87509872	E081	18916
chr16	87510394	87510476	E081	19575
chr16	87510669	87510752	E081	19850
chr16	87510847	87510902	E081	20028
chr16	87510929	87511529	E081	20110
chr16	87515818	87516128	E081	24999
chr16	87516744	87516784	E081	25925
chr16	87517197	87517475	E081	26378
chr16	87517673	87517723	E081	26854
chr16	87517844	87517898	E081	27025
chr16	87517959	87518365	E081	27140
chr16	87518370	87518589	E081	27551
chr16	87518629	87518708	E081	27810
chr16	87518730	87518848	E081	27911
chr16	87519327	87519367	E081	28508
chr16	87519424	87519590	E081	28605
chr16	87519645	87519742	E081	28826
chr16	87519790	87519831	E081	28971
chr16	87519959	87520035	E081	29140
chr16	87520047	87520148	E081	29228
chr16	87520334	87520459	E081	29515
chr16	87520489	87520775	E081	29670
chr16	87521726	87521803	E081	30907
chr16	87521934	87521997	E081	31115
chr16	87522037	87522097	E081	31218
chr16	87522269	87522309	E081	31450
chr16	87522426	87522486	E081	31607
chr16	87522612	87522874	E081	31793
chr16	87527621	87527759	E081	36802
chr16	87489373	87489868	E082	-951
chr16	87519645	87519742	E082	28826
chr16	87519790	87519831	E082	28971
chr16	87519959	87520035	E082	29140
chr16	87520047	87520148	E082	29228

Promoter Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr16	87523945	87524785	E067	33126
chr16	87525319	87525586	E067	34500
chr16	87525676	87525886	E067	34857
chr16	87526297	87527176	E067	35478
chr16	87523945	87524785	E068	33126
chr16	87525319	87525586	E068	34500
chr16	87525676	87525886	E068	34857
chr16	87523945	87524785	E069	33126
chr16	87525319	87525586	E069	34500
chr16	87525676	87525886	E069	34857
chr16	87525972	87526113	E069	35153
chr16	87526115	87526170	E069	35296
chr16	87526171	87526248	E069	35352
chr16	87526297	87527176	E069	35478
chr16	87523945	87524785	E070	33126
chr16	87525319	87525586	E070	34500
chr16	87525676	87525886	E070	34857
chr16	87525972	87526113	E070	35153
chr16	87526115	87526170	E070	35296
chr16	87526171	87526248	E070	35352
chr16	87526297	87527176	E070	35478
chr16	87523945	87524785	E071	33126
chr16	87525319	87525586	E071	34500
chr16	87525676	87525886	E071	34857
chr16	87523945	87524785	E072	33126
chr16	87525319	87525586	E072	34500
chr16	87525676	87525886	E072	34857
chr16	87525972	87526113	E072	35153
chr16	87526115	87526170	E072	35296
chr16	87526171	87526248	E072	35352
chr16	87526297	87527176	E072	35478
chr16	87523945	87524785	E073	33126
chr16	87525319	87525586	E073	34500
chr16	87525676	87525886	E073	34857
chr16	87523945	87524785	E074	33126
chr16	87525319	87525586	E074	34500
chr16	87525676	87525886	E074	34857
chr16	87536008	87536048	E081	45189
chr16	87523945	87524785	E082	33126
chr16	87525319	87525586	E082	34500
chr16	87525676	87525886	E082	34857
chr16	87525972	87526113	E082	35153
chr16	87526115	87526170	E082	35296
chr16	87526171	87526248	E082	35352
chr16	87526297	87527176	E082	35478