rs13336754

Homo sapiens
C>A / C>T
TNRC6A : Missense Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0260 (7797/29924,GnomAD)
T=0250 (7283/29118,TOPMED)
C==0278 (3616/12994,GO-ESP)
T=0166 (833/5008,1000G)
T=0277 (1066/3854,ALSPAC)
T=0279 (1034/3708,TWINSUK)
chr16:24790658 (GRCh38.p7) (16p12.1)
AD
GWASdb2
1   publication(s)
See rs on genome
0 Enhancer around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 16NC_000016.10:g.24790658C>A
GRCh38.p7 chr 16NC_000016.10:g.24790658C>T
GRCh37.p13 chr 16NC_000016.9:g.24801979C>A
GRCh37.p13 chr 16NC_000016.9:g.24801979C>T

Gene: TNRC6A, trinucleotide repeat containing 6A(plus strand)

Molecule type Change Amino acid[Codon] SO Term
TNRC6A transcript variant 1NM_014494.2:c.201...NM_014494.2:c.2016C>AS [AGC]> R [AGA]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform 1NP_055309.2:p.Ser...NP_055309.2:p.Ser672ArgS [Ser]> R [Arg]Missense Variant
TNRC6A transcript variant 1NM_014494.2:c.201...NM_014494.2:c.2016C>TS [AGC]> S [AGT]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform 1NP_055309.2:p.Ser...NP_055309.2:p.Ser672=S [Ser]> S [Ser]Synonymous Variant
TNRC6A transcript variant X1XM_017023143.1:c....XM_017023143.1:c.2043C>AS [AGC]> R [AGA]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X1XP_016878632.1:p....XP_016878632.1:p.Ser681ArgS [Ser]> R [Arg]Missense Variant
TNRC6A transcript variant X1XM_017023143.1:c....XM_017023143.1:c.2043C>TS [AGC]> S [AGT]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X1XP_016878632.1:p....XP_016878632.1:p.Ser681=S [Ser]> S [Ser]Synonymous Variant
TNRC6A transcript variant X2XM_017023144.1:c....XM_017023144.1:c.2043C>AS [AGC]> R [AGA]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X2XP_016878633.1:p....XP_016878633.1:p.Ser681ArgS [Ser]> R [Arg]Missense Variant
TNRC6A transcript variant X2XM_017023144.1:c....XM_017023144.1:c.2043C>TS [AGC]> S [AGT]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X2XP_016878633.1:p....XP_016878633.1:p.Ser681=S [Ser]> S [Ser]Synonymous Variant
TNRC6A transcript variant X3XM_017023145.1:c....XM_017023145.1:c.2043C>AS [AGC]> R [AGA]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X3XP_016878634.1:p....XP_016878634.1:p.Ser681ArgS [Ser]> R [Arg]Missense Variant
TNRC6A transcript variant X3XM_017023145.1:c....XM_017023145.1:c.2043C>TS [AGC]> S [AGT]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X3XP_016878634.1:p....XP_016878634.1:p.Ser681=S [Ser]> S [Ser]Synonymous Variant
TNRC6A transcript variant X4XM_017023146.1:c....XM_017023146.1:c.1968C>AS [AGC]> R [AGA]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X4XP_016878635.1:p....XP_016878635.1:p.Ser656ArgS [Ser]> R [Arg]Missense Variant
TNRC6A transcript variant X4XM_017023146.1:c....XM_017023146.1:c.1968C>TS [AGC]> S [AGT]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X4XP_016878635.1:p....XP_016878635.1:p.Ser656=S [Ser]> S [Ser]Synonymous Variant
TNRC6A transcript variant X5XM_017023147.1:c....XM_017023147.1:c.2043C>AS [AGC]> R [AGA]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X5XP_016878636.1:p....XP_016878636.1:p.Ser681ArgS [Ser]> R [Arg]Missense Variant
TNRC6A transcript variant X5XM_017023147.1:c....XM_017023147.1:c.2043C>TS [AGC]> S [AGT]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X5XP_016878636.1:p....XP_016878636.1:p.Ser681=S [Ser]> S [Ser]Synonymous Variant
TNRC6A transcript variant X6XM_005255254.3:c....XM_005255254.3:c.2016C>AS [AGC]> R [AGA]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X6XP_005255311.1:p....XP_005255311.1:p.Ser672ArgS [Ser]> R [Arg]Missense Variant
TNRC6A transcript variant X6XM_005255254.3:c....XM_005255254.3:c.2016C>TS [AGC]> S [AGT]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X6XP_005255311.1:p....XP_005255311.1:p.Ser672=S [Ser]> S [Ser]Synonymous Variant
TNRC6A transcript variant X7XM_017023148.1:c....XM_017023148.1:c.2043C>AS [AGC]> R [AGA]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X5XP_016878637.1:p....XP_016878637.1:p.Ser681ArgS [Ser]> R [Arg]Missense Variant
TNRC6A transcript variant X7XM_017023148.1:c....XM_017023148.1:c.2043C>TS [AGC]> S [AGT]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X5XP_016878637.1:p....XP_016878637.1:p.Ser681=S [Ser]> S [Ser]Synonymous Variant
TNRC6A transcript variant X8XM_017023149.1:c....XM_017023149.1:c.2043C>AS [AGC]> R [AGA]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X8XP_016878638.1:p....XP_016878638.1:p.Ser681ArgS [Ser]> R [Arg]Missense Variant
TNRC6A transcript variant X8XM_017023149.1:c....XM_017023149.1:c.2043C>TS [AGC]> S [AGT]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X8XP_016878638.1:p....XP_016878638.1:p.Ser681=S [Ser]> S [Ser]Synonymous Variant
TNRC6A transcript variant X9XM_017023150.1:c....XM_017023150.1:c.2043C>AS [AGC]> R [AGA]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X7XP_016878639.1:p....XP_016878639.1:p.Ser681ArgS [Ser]> R [Arg]Missense Variant
TNRC6A transcript variant X9XM_017023150.1:c....XM_017023150.1:c.2043C>TS [AGC]> S [AGT]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X7XP_016878639.1:p....XP_016878639.1:p.Ser681=S [Ser]> S [Ser]Synonymous Variant
TNRC6A transcript variant X10XM_017023151.1:c....XM_017023151.1:c.2043C>AS [AGC]> R [AGA]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X10XP_016878640.1:p....XP_016878640.1:p.Ser681ArgS [Ser]> R [Arg]Missense Variant
TNRC6A transcript variant X10XM_017023151.1:c....XM_017023151.1:c.2043C>TS [AGC]> S [AGT]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X10XP_016878640.1:p....XP_016878640.1:p.Ser681=S [Ser]> S [Ser]Synonymous Variant
TNRC6A transcript variant X11XM_017023152.1:c....XM_017023152.1:c.1617C>AS [AGC]> R [AGA]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X9XP_016878641.1:p....XP_016878641.1:p.Ser539ArgS [Ser]> R [Arg]Missense Variant
TNRC6A transcript variant X11XM_017023152.1:c....XM_017023152.1:c.1617C>TS [AGC]> S [AGT]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X9XP_016878641.1:p....XP_016878641.1:p.Ser539=S [Ser]> S [Ser]Synonymous Variant
TNRC6A transcript variant X10XM_017023153.1:c....XM_017023153.1:c.1257C>AS [AGC]> R [AGA]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X10XP_016878642.1:p....XP_016878642.1:p.Ser419ArgS [Ser]> R [Arg]Missense Variant
TNRC6A transcript variant X10XM_017023153.1:c....XM_017023153.1:c.1257C>TS [AGC]> S [AGT]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X10XP_016878642.1:p....XP_016878642.1:p.Ser419=S [Ser]> S [Ser]Synonymous Variant
TNRC6A transcript variant X11XM_005255257.4:c....XM_005255257.4:c.1257C>AS [AGC]> R [AGA]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X10XP_005255314.1:p....XP_005255314.1:p.Ser419ArgS [Ser]> R [Arg]Missense Variant
TNRC6A transcript variant X11XM_005255257.4:c....XM_005255257.4:c.1257C>TS [AGC]> S [AGT]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X10XP_005255314.1:p....XP_005255314.1:p.Ser419=S [Ser]> S [Ser]Synonymous Variant
TNRC6A transcript variant X12XM_017023154.1:c....XM_017023154.1:c.1257C>AS [AGC]> R [AGA]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X11XP_016878643.1:p....XP_016878643.1:p.Ser419ArgS [Ser]> R [Arg]Missense Variant
TNRC6A transcript variant X12XM_017023154.1:c....XM_017023154.1:c.1257C>TS [AGC]> S [AGT]Coding Sequence Variant
trinucleotide repeat-containing gene 6A protein isoform X11XP_016878643.1:p....XP_016878643.1:p.Ser419=S [Ser]> S [Ser]Synonymous Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.731T=0.269
1000GenomesAmericanSub694C=0.860T=0.140
1000GenomesEast AsianSub1008C=0.998T=0.002
1000GenomesEuropeSub1006C=0.724T=0.276
1000GenomesGlobalStudy-wide5008C=0.834T=0.166
1000GenomesSouth AsianSub978C=0.900T=0.100
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.723T=0.277
The Genome Aggregation DatabaseAfricanSub8704C=0.709T=0.291
The Genome Aggregation DatabaseAmericanSub836C=0.860T=0.140
The Genome Aggregation DatabaseEast AsianSub1618C=0.999T=0.001
The Genome Aggregation DatabaseEuropeSub18464C=0.724T=0.275
The Genome Aggregation DatabaseGlobalStudy-wide29924C=0.739T=0.260
The Genome Aggregation DatabaseOtherSub302C=0.800T=0.200
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.749T=0.250
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.721T=0.279
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs133367540.00093alcohol dependence20201924

eQTL of rs13336754 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs13336754 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.