rs1341260

Homo sapiens
T>C
ADGRL2 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0153 (4607/29970,GnomAD)
C=0159 (4639/29118,TOPMED)
C=0125 (626/5008,1000G)
C=0223 (858/3854,ALSPAC)
C=0217 (804/3708,TWINSUK)
chr1:81898976 (GRCh38.p7) (1p31.1)
ND
GWASdb2
1   publication(s)
See rs on genome
1 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 1NC_000001.11:g.81898976T>C
GRCh37.p13 chr 1NC_000001.10:g.82364661T>C

Gene: ADGRL2, adhesion G protein-coupled receptor L2(plus strand)

Molecule type Change Amino acid[Codon] SO Term
ADGRL2 transcript variant 2NM_001297704.1:c.N/AIntron Variant
ADGRL2 transcript variant 3NM_001297705.1:c.N/AIntron Variant
ADGRL2 transcript variant 4NM_001297706.1:c.N/AIntron Variant
ADGRL2 transcript variant 1NM_012302.3:c.N/AIntron Variant
ADGRL2 transcript variant X7XM_005270666.4:c.N/AIntron Variant
ADGRL2 transcript variant X10XM_005270668.2:c.N/AIntron Variant
ADGRL2 transcript variant X1XM_006710485.3:c.N/AIntron Variant
ADGRL2 transcript variant X2XM_006710488.2:c.N/AIntron Variant
ADGRL2 transcript variant X4XM_006710489.3:c.N/AIntron Variant
ADGRL2 transcript variant X2XM_017000782.1:c.N/AIntron Variant
ADGRL2 transcript variant X3XM_017000783.1:c.N/AIntron Variant
ADGRL2 transcript variant X3XM_017000784.1:c.N/AIntron Variant
ADGRL2 transcript variant X7XM_017000785.1:c.N/AIntron Variant
ADGRL2 transcript variant X6XM_017000786.1:c.N/AIntron Variant
ADGRL2 transcript variant X9XM_017000787.1:c.N/AIntron Variant
ADGRL2 transcript variant X11XM_017000788.1:c.N/AIntron Variant
ADGRL2 transcript variant X12XM_017000789.1:c.N/AIntron Variant
ADGRL2 transcript variant X14XM_017000790.1:c.N/AIntron Variant
ADGRL2 transcript variant X15XM_017000791.1:c.N/AIntron Variant
ADGRL2 transcript variant X16XM_017000792.1:c.N/AIntron Variant
ADGRL2 transcript variant X20XM_017000793.1:c.N/AIntron Variant
ADGRL2 transcript variant X23XM_017000794.1:c.N/AIntron Variant
ADGRL2 transcript variant X24XM_017000795.1:c.N/AIntron Variant
ADGRL2 transcript variant X14XM_017000796.1:c.N/AIntron Variant
ADGRL2 transcript variant X26XM_017000797.1:c.N/AIntron Variant
ADGRL2 transcript variant X27XM_017000798.1:c.N/AIntron Variant
ADGRL2 transcript variant X17XR_001737067.1:n.N/AIntron Variant
ADGRL2 transcript variant X18XR_001737068.1:n.N/AIntron Variant
ADGRL2 transcript variant X19XR_001737069.1:n.N/AIntron Variant
ADGRL2 transcript variant X21XR_001737070.1:n.N/AIntron Variant
ADGRL2 transcript variant X22XR_001737071.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.927C=0.073
1000GenomesAmericanSub694T=0.860C=0.140
1000GenomesEast AsianSub1008T=0.962C=0.038
1000GenomesEuropeSub1006T=0.791C=0.209
1000GenomesGlobalStudy-wide5008T=0.875C=0.125
1000GenomesSouth AsianSub978T=0.810C=0.190
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.777C=0.223
The Genome Aggregation DatabaseAfricanSub8724T=0.910C=0.090
The Genome Aggregation DatabaseAmericanSub838T=0.830C=0.170
The Genome Aggregation DatabaseEast AsianSub1614T=0.947C=0.053
The Genome Aggregation DatabaseEuropeSub18492T=0.811C=0.188
The Genome Aggregation DatabaseGlobalStudy-wide29970T=0.846C=0.153
The Genome Aggregation DatabaseOtherSub302T=0.630C=0.370
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.840C=0.159
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.783C=0.217
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs13412600.000661nicotine dependence17158188

eQTL of rs1341260 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1341260 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr18238583582386483E06821174
chr18231504382315226E070-49435
chr18235108782351284E070-13377
chr18238583582386483E07221174
chr18236626282366312E0731601
chr18231504382315226E081-49435
chr18234352382343609E081-21052
chr18234377382343929E081-20732
chr18234868282348819E081-15842
chr18234899182349090E081-15571
chr18231867082319028E082-45633
chr18231915182319221E082-45440
chr18234424582344490E082-20171
chr18234841582348465E082-16196
chr18234868282348819E082-15842
chr18234899182349090E082-15571






Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr18241137782411427E06746716