rs1344815

Homo sapiens
A>G
WWTR1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A==0458 (13707/29924,GnomAD)
A==0453 (13190/29118,TOPMED)
G=0460 (2306/5008,1000G)
A==0368 (1420/3854,ALSPAC)
A==0349 (1294/3708,TWINSUK)
chr3:149623026 (GRCh38.p7) (3q25.1)
AD
GWASdb2
1   publication(s)
See rs on genome
208 Enhancers around
19 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.149623026A>G
GRCh37.p13 chr 3NC_000003.11:g.149340813A>G

Gene: WWTR1, WW domain containing transcription regulator 1(minus strand)

Molecule type Change Amino acid[Codon] SO Term
WWTR1 transcript variant 2NM_001168278.1:c.N/AIntron Variant
WWTR1 transcript variant 3NM_001168280.1:c.N/AIntron Variant
WWTR1 transcript variant 1NM_015472.4:c.N/AIntron Variant
WWTR1 transcript variant X1XM_017006121.1:c.N/AIntron Variant
WWTR1 transcript variant X1XM_017006122.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.654G=0.346
1000GenomesAmericanSub694A=0.520G=0.480
1000GenomesEast AsianSub1008A=0.667G=0.333
1000GenomesEuropeSub1006A=0.350G=0.650
1000GenomesGlobalStudy-wide5008A=0.540G=0.460
1000GenomesSouth AsianSub978A=0.460G=0.540
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.368G=0.632
The Genome Aggregation DatabaseAfricanSub8704A=0.594G=0.406
The Genome Aggregation DatabaseAmericanSub836A=0.530G=0.470
The Genome Aggregation DatabaseEast AsianSub1610A=0.725G=0.275
The Genome Aggregation DatabaseEuropeSub18474A=0.370G=0.629
The Genome Aggregation DatabaseGlobalStudy-wide29924A=0.458G=0.541
The Genome Aggregation DatabaseOtherSub300A=0.300G=0.700
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.453G=0.547
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.349G=0.651
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs13448150.00075alcohol dependence20201924

eQTL of rs1344815 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1344815 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr3149293158149294480E067-46333
chr3149298848149298917E067-41896
chr3149304761149304956E067-35857
chr3149308522149308779E067-32034
chr3149327988149328641E067-12172
chr3149335966149336209E067-4604
chr3149348580149349007E0677767
chr3149355456149355618E06714643
chr3149355674149355744E06714861
chr3149355900149356028E06715087
chr3149359059149359262E06718246
chr3149359298149359436E06718485
chr3149292986149293146E068-47667
chr3149294512149294577E068-46236
chr3149294930149295408E068-45405
chr3149298625149298796E068-42017
chr3149298848149298917E068-41896
chr3149299011149300464E068-40349
chr3149301475149301622E068-39191
chr3149301660149301744E068-39069
chr3149301816149301977E068-38836
chr3149302130149302295E068-38518
chr3149308522149308779E068-32034
chr3149309002149309130E068-31683
chr3149310425149311137E068-29676
chr3149311212149311525E068-29288
chr3149311682149311773E068-29040
chr3149319629149319692E068-21121
chr3149319995149320047E068-20766
chr3149320179149320366E068-20447
chr3149320699149320775E068-20038
chr3149320919149321192E068-19621
chr3149321301149321599E068-19214
chr3149321616149321738E068-19075
chr3149322018149322188E068-18625
chr3149322217149322794E068-18019
chr3149327401149327760E068-13053
chr3149327808149327920E068-12893
chr3149327988149328641E068-12172
chr3149328967149329083E068-11730
chr3149329116149329172E068-11641
chr3149330422149330466E068-10347
chr3149330921149331104E068-9709
chr3149335056149335177E068-5636
chr3149335966149336209E068-4604
chr3149348440149348494E0687627
chr3149348580149349007E0687767
chr3149352010149352163E06811197
chr3149352487149352670E06811674
chr3149352706149352750E06811893
chr3149355456149355618E06814643
chr3149355674149355744E06814861
chr3149355900149356028E06815087
chr3149359059149359262E06818246
chr3149359298149359436E06818485
chr3149359601149359704E06818788
chr3149360894149360994E06820081
chr3149361506149361610E06820693
chr3149361904149361996E06821091
chr3149365790149365908E06824977
chr3149365976149366098E06825163
chr3149292986149293146E069-47667
chr3149293158149294480E069-46333
chr3149301816149301977E069-38836
chr3149302130149302295E069-38518
chr3149308522149308779E069-32034
chr3149327401149327760E069-13053
chr3149327808149327920E069-12893
chr3149327988149328641E069-12172
chr3149328967149329083E069-11730
chr3149329116149329172E069-11641
chr3149348440149348494E0697627
chr3149348580149349007E0697767
chr3149359059149359262E06918246
chr3149359298149359436E06918485
chr3149366254149366737E06925441
chr3149371165149371209E06930352
chr3149371343149371480E06930530
chr3149371518149371568E06930705
chr3149371641149371731E06930828
chr3149292986149293146E070-47667
chr3149293158149294480E070-46333
chr3149310425149311137E070-29676
chr3149311212149311525E070-29288
chr3149311682149311773E070-29040
chr3149312316149312469E070-28344
chr3149319995149320047E070-20766
chr3149320179149320366E070-20447
chr3149320699149320775E070-20038
chr3149320919149321192E070-19621
chr3149321301149321599E070-19214
chr3149321616149321738E070-19075
chr3149322018149322188E070-18625
chr3149322217149322794E070-18019
chr3149327808149327920E070-12893
chr3149327988149328641E070-12172
chr3149355456149355618E07014643
chr3149355674149355744E07014861
chr3149355900149356028E07015087
chr3149293158149294480E071-46333
chr3149297044149297246E071-43567
chr3149297582149298303E071-42510
chr3149299011149300464E071-40349
chr3149301475149301622E071-39191
chr3149301660149301744E071-39069
chr3149301816149301977E071-38836
chr3149302130149302295E071-38518
chr3149302510149302562E071-38251
chr3149304761149304956E071-35857
chr3149304963149305084E071-35729
chr3149310425149311137E071-29676
chr3149311212149311525E071-29288
chr3149320919149321192E071-19621
chr3149321301149321599E071-19214
chr3149321616149321738E071-19075
chr3149322018149322188E071-18625
chr3149322217149322794E071-18019
chr3149322843149322937E071-17876
chr3149327808149327920E071-12893
chr3149327988149328641E071-12172
chr3149328967149329083E071-11730
chr3149329116149329172E071-11641
chr3149335056149335177E071-5636
chr3149335966149336209E071-4604
chr3149336535149336957E071-3856
chr3149348440149348494E0717627
chr3149348580149349007E0717767
chr3149351800149351882E07110987
chr3149352010149352163E07111197
chr3149352487149352670E07111674
chr3149352706149352750E07111893
chr3149355456149355618E07114643
chr3149355674149355744E07114861
chr3149355900149356028E07115087
chr3149359059149359262E07118246
chr3149359298149359436E07118485
chr3149359601149359704E07118788
chr3149361304149361362E07120491
chr3149361904149361996E07121091
chr3149365976149366098E07125163
chr3149366254149366737E07125441
chr3149371518149371568E07130705
chr3149293158149294480E072-46333
chr3149327988149328641E072-12172
chr3149348440149348494E0727627
chr3149348580149349007E0727767
chr3149359059149359262E07218246
chr3149359298149359436E07218485
chr3149293158149294480E073-46333
chr3149295604149296016E073-44797
chr3149299011149300464E073-40349
chr3149320179149320366E073-20447
chr3149320699149320775E073-20038
chr3149320919149321192E073-19621
chr3149322018149322188E073-18625
chr3149322217149322794E073-18019
chr3149335966149336209E073-4604
chr3149348440149348494E0737627
chr3149352487149352670E07311674
chr3149352706149352750E07311893
chr3149365976149366098E07325163
chr3149366254149366737E07325441
chr3149371165149371209E07330352
chr3149371343149371480E07330530
chr3149371518149371568E07330705
chr3149377243149377299E07336430
chr3149377526149377609E07336713
chr3149292821149292905E074-47908
chr3149292986149293146E074-47667
chr3149293158149294480E074-46333
chr3149301475149301622E074-39191
chr3149301660149301744E074-39069
chr3149301816149301977E074-38836
chr3149310425149311137E074-29676
chr3149327988149328641E074-12172
chr3149328967149329083E074-11730
chr3149329116149329172E074-11641
chr3149348440149348494E0747627
chr3149348580149349007E0747767
chr3149352487149352670E07411674
chr3149352706149352750E07411893
chr3149358620149359026E07417807
chr3149359059149359262E07418246
chr3149359298149359436E07418485
chr3149293158149294480E081-46333
chr3149295604149296016E081-44797
chr3149296278149296328E081-44485
chr3149297044149297246E081-43567
chr3149297582149298303E081-42510
chr3149311682149311773E081-29040
chr3149318517149318864E081-21949
chr3149327401149327760E081-13053
chr3149327808149327920E081-12893
chr3149327988149328641E081-12172
chr3149292986149293146E082-47667
chr3149293158149294480E082-46333
chr3149295604149296016E082-44797
chr3149296278149296328E082-44485
chr3149297044149297246E082-43567
chr3149299011149300464E082-40349
chr3149310425149311137E082-29676
chr3149311212149311525E082-29288
chr3149311682149311773E082-29040
chr3149318517149318864E082-21949
chr3149327988149328641E082-12172
chr3149328967149329083E082-11730
chr3149329116149329172E082-11641
chr3149355900149356028E08215087










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr3149373943149377198E06733130
chr3149373321149373699E06832508
chr3149373702149373835E06832889
chr3149373943149377198E06833130
chr3149373702149373835E06932889
chr3149373943149377198E06933130
chr3149373321149373699E07032508
chr3149373702149373835E07032889
chr3149373321149373699E07132508
chr3149373702149373835E07132889
chr3149373943149377198E07133130
chr3149373321149373699E07232508
chr3149373702149373835E07232889
chr3149373943149377198E07233130
chr3149373321149373699E07332508
chr3149373702149373835E07332889
chr3149373943149377198E07333130
chr3149373943149377198E07433130
chr3149373943149377198E08233130