rs135015

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0332 (9808/29530,GnomAD)
C=0286 (8343/29114,TOPMED)
C=0296 (1483/5008,1000G)
C=0418 (1610/3854,ALSPAC)
C=0418 (1549/3708,TWINSUK)
chr22:43102155 (GRCh38.p7) (22q13.2)
AD
GWASdb2
1   publication(s)
See rs on genome
54 Enhancers around
30 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 22NC_000022.11:g.43102155T>C
GRCh37.p13 chr 22NC_000022.10:g.43498161T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.914C=0.086
1000GenomesAmericanSub694T=0.720C=0.280
1000GenomesEast AsianSub1008T=0.632C=0.368
1000GenomesEuropeSub1006T=0.576C=0.424
1000GenomesGlobalStudy-wide5008T=0.704C=0.296
1000GenomesSouth AsianSub978T=0.620C=0.380
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.582C=0.418
The Genome Aggregation DatabaseAfricanSub8658T=0.863C=0.137
The Genome Aggregation DatabaseAmericanSub834T=0.680C=0.320
The Genome Aggregation DatabaseEast AsianSub1610T=0.629C=0.371
The Genome Aggregation DatabaseEuropeSub18128T=0.578C=0.421
The Genome Aggregation DatabaseGlobalStudy-wide29530T=0.667C=0.332
The Genome Aggregation DatabaseOtherSub300T=0.640C=0.360
Trans-Omics for Precision MedicineGlobalStudy-wide29114T=0.713C=0.286
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.582C=0.418
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs1350150.000702alcohol dependence21314694

eQTL of rs135015 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr22:43498161AL022476.2ENSG00000230319.1T>C1.3070e-663570Cerebellum
Chr22:43498161TTLL1ENSG00000100271.12T>C5.6463e-912727Cortex
Chr22:43498161AL022476.2ENSG00000230319.1T>C4.1896e-363570Cerebellar_Hemisphere

meQTL of rs135015 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr224347331643473853E067-24308
chr224353725143537305E06739090
chr224353739843537438E06739237
chr224353746143537517E06739300
chr224353753843537594E06739377
chr224353787443537914E06739713
chr224353804643538167E06739885
chr224353804643538167E06839885
chr224347331643473853E069-24308
chr224353787443537914E06939713
chr224353804643538167E06939885
chr224354656043546709E06948399
chr224347331643473853E070-24308
chr224353702443537142E07038863
chr224353725143537305E07039090
chr224353739843537438E07039237
chr224353746143537517E07039300
chr224353753843537594E07039377
chr224353787443537914E07039713
chr224353804643538167E07039885
chr224347331643473853E071-24308
chr224348589843485992E071-12169
chr224353787443537914E07139713
chr224353804643538167E07139885
chr224353804643538167E07239885
chr224347331643473853E073-24308
chr224353702443537142E07338863
chr224353725143537305E07339090
chr224353739843537438E07339237
chr224353746143537517E07339300
chr224353753843537594E07339377
chr224353787443537914E07339713
chr224353804643538167E07339885
chr224347331643473853E074-24308
chr224348589843485992E074-12169
chr224350803143508099E0749870
chr224350814343508193E0749982
chr224353787443537914E07439713
chr224353804643538167E07439885
chr224347331643473853E081-24308
chr224347397043474092E081-24069
chr224347413443474224E081-23937
chr224347457243474818E081-23343
chr224347503043475197E081-22964
chr224348421643484274E081-13887
chr224353804643538167E08139885
chr224347331643473853E082-24308
chr224348190343483171E082-14990
chr224353691643536966E08238755
chr224353702443537142E08238863
chr224353725143537305E08239090
chr224353739843537438E08239237
chr224353746143537517E08239300
chr224353753843537594E08239377










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr224348466443485796E067-12365
chr224350568743507998E0677526
chr224353870243538754E06740541
chr224353879343539809E06740632
chr224348466443485796E068-12365
chr224350568743507998E0687526
chr224353870243538754E06840541
chr224353879343539809E06840632
chr224348466443485796E069-12365
chr224353870243538754E06940541
chr224353879343539809E06940632
chr224348466443485796E070-12365
chr224353870243538754E07040541
chr224353879343539809E07040632
chr224348466443485796E071-12365
chr224353870243538754E07140541
chr224353879343539809E07140632
chr224348466443485796E072-12365
chr224353879343539809E07240632
chr224348466443485796E073-12365
chr224353870243538754E07340541
chr224353879343539809E07340632
chr224348466443485796E074-12365
chr224350568743507998E0747526
chr224353879343539809E07440632
chr224348466443485796E081-12365
chr224348466443485796E082-12365
chr224350568743507998E0827526
chr224353870243538754E08240541
chr224353879343539809E08240632