rs1363605

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0249 (7474/29956,GnomAD)
T=0292 (8507/29118,TOPMED)
T=0368 (1844/5008,1000G)
T=0152 (584/3854,ALSPAC)
T=0157 (581/3708,TWINSUK)
chr5:173590084 (GRCh38.p7) (5q35.2)
AD
GWASCatalog | GWASdb2
3   publication(s)
See rs on genome
214 Enhancers around
9 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.173590084C>T
GRCh37.p13 chr 5NC_000005.9:g.173017087C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.567T=0.433
1000GenomesAmericanSub694C=0.820T=0.180
1000GenomesEast AsianSub1008C=0.384T=0.616
1000GenomesEuropeSub1006C=0.829T=0.171
1000GenomesGlobalStudy-wide5008C=0.632T=0.368
1000GenomesSouth AsianSub978C=0.640T=0.360
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.848T=0.152
The Genome Aggregation DatabaseAfricanSub8710C=0.609T=0.391
The Genome Aggregation DatabaseAmericanSub836C=0.780T=0.220
The Genome Aggregation DatabaseEast AsianSub1612C=0.346T=0.654
The Genome Aggregation DatabaseEuropeSub18496C=0.850T=0.149
The Genome Aggregation DatabaseGlobalStudy-wide29956C=0.750T=0.249
The Genome Aggregation DatabaseOtherSub302C=0.760T=0.240
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.707T=0.292
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.843T=0.157
PMID Title Author Journal
27151647An association study revealed substantial effects of dominance, epistasis and substance dependence co-morbidity on alcohol dependence symptom count.Chen GAddict Biol
20202923A genome-wide association study of alcohol dependence.Bierut LJProc Natl Acad Sci U S A
21956439Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q.Zuo LNeuropsychopharmacology

P-Value

SNP ID p-value Traits Study
rs13636051.00E-15alcohol dependence27151647
rs13636050.000068alcohol dependence21956439

eQTL of rs1363605 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1363605 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr5172981014172981262E067-35825
chr5172982396172982694E067-34393
chr5172983515172983686E067-33401
chr5172983799172983970E067-33117
chr5172984279172984501E067-32586
chr5172984641172984782E067-32305
chr5172998764172998845E067-18242
chr5172999165172999351E067-17736
chr5172999609172999744E067-17343
chr5172999989173000457E067-16630
chr5173031965173032015E06714878
chr5173039557173039637E06722470
chr5173044366173044492E06727279
chr5173045550173045651E06728463
chr5173045720173045833E06728633
chr5173045886173045975E06728799
chr5173046017173046349E06728930
chr5173046385173046476E06729298
chr5173046654173046747E06729567
chr5173052411173052545E06735324
chr5173052614173052959E06735527
chr5173053057173053228E06735970
chr5173053232173053329E06736145
chr5173053566173053648E06736479
chr5173053836173053903E06736749
chr5173054837173055697E06737750
chr5173055742173055811E06738655
chr5173057598173057648E06740511
chr5173057670173058054E06740583
chr5172981014172981262E068-35825
chr5172982396172982694E068-34393
chr5172983515172983686E068-33401
chr5172983799172983970E068-33117
chr5172984279172984501E068-32586
chr5172984641172984782E068-32305
chr5172999609172999744E068-17343
chr5172999989173000457E068-16630
chr5173025684173025748E0688597
chr5173025809173025921E0688722
chr5173025975173026222E0688888
chr5173031148173031280E06814061
chr5173031965173032015E06814878
chr5173039557173039637E06822470
chr5173040111173040252E06823024
chr5173040332173040690E06823245
chr5173044366173044492E06827279
chr5173051920173052027E06834833
chr5173052411173052545E06835324
chr5173052614173052959E06835527
chr5173053057173053228E06835970
chr5173053232173053329E06836145
chr5173053566173053648E06836479
chr5173053836173053903E06836749
chr5173054837173055697E06837750
chr5173055742173055811E06838655
chr5173056112173056200E06839025
chr5173056420173056460E06839333
chr5173056565173056765E06839478
chr5173056802173056962E06839715
chr5172981014172981262E069-35825
chr5172982396172982694E069-34393
chr5172983515172983686E069-33401
chr5172983799172983970E069-33117
chr5173017532173017637E069445
chr5173017697173017747E069610
chr5173017750173018316E069663
chr5173018332173018549E0691245
chr5173029541173029766E06912454
chr5173031148173031280E06914061
chr5173040111173040252E06923024
chr5173040332173040690E06923245
chr5173044366173044492E06927279
chr5173045886173045975E06928799
chr5173046017173046349E06928930
chr5173052411173052545E06935324
chr5173052614173052959E06935527
chr5173053566173053648E06936479
chr5173054837173055697E06937750
chr5173055742173055811E06938655
chr5173056112173056200E06939025
chr5173056420173056460E06939333
chr5173056565173056765E06939478
chr5173056802173056962E06939715
chr5173057598173057648E06940511
chr5173057670173058054E06940583
chr5173065416173065816E06948329
chr5172981014172981262E070-35825
chr5172982396172982694E070-34393
chr5172983515172983686E070-33401
chr5172983799172983970E070-33117
chr5172984279172984501E070-32586
chr5172984641172984782E070-32305
chr5173044366173044492E07027279
chr5173052614173052959E07035527
chr5173053057173053228E07035970
chr5173054837173055697E07037750
chr5173057598173057648E07040511
chr5173057670173058054E07040583
chr5172981014172981262E071-35825
chr5172982396172982694E071-34393
chr5172983515172983686E071-33401
chr5172983799172983970E071-33117
chr5172984279172984501E071-32586
chr5172984641172984782E071-32305
chr5172999609172999744E071-17343
chr5173017750173018316E071663
chr5173018332173018549E0711245
chr5173025809173025921E0718722
chr5173025975173026222E0718888
chr5173031148173031280E07114061
chr5173044617173044823E07127530
chr5173046017173046349E07128930
chr5173046385173046476E07129298
chr5173052411173052545E07135324
chr5173052614173052959E07135527
chr5173053232173053329E07136145
chr5173053566173053648E07136479
chr5173053836173053903E07136749
chr5173054837173055697E07137750
chr5173055742173055811E07138655
chr5173056112173056200E07139025
chr5173056420173056460E07139333
chr5173056565173056765E07139478
chr5173056802173056962E07139715
chr5173057598173057648E07140511
chr5173057670173058054E07140583
chr5172981014172981262E072-35825
chr5172982396172982694E072-34393
chr5172983515172983686E072-33401
chr5172983799172983970E072-33117
chr5172984279172984501E072-32586
chr5172984641172984782E072-32305
chr5172999609172999744E072-17343
chr5172999989173000457E072-16630
chr5173000549173000594E072-16493
chr5173017750173018316E072663
chr5173018332173018549E0721245
chr5173025809173025921E0728722
chr5173031148173031280E07214061
chr5173044366173044492E07227279
chr5173044617173044823E07227530
chr5173051920173052027E07234833
chr5173052411173052545E07235324
chr5173053232173053329E07236145
chr5173053566173053648E07236479
chr5173054837173055697E07237750
chr5173055742173055811E07238655
chr5173056802173056962E07239715
chr5173057598173057648E07240511
chr5172981014172981262E073-35825
chr5172983515172983686E073-33401
chr5172983799172983970E073-33117
chr5173025684173025748E0738597
chr5173025809173025921E0738722
chr5173025975173026222E0738888
chr5173044366173044492E07327279
chr5173052411173052545E07335324
chr5173052614173052959E07335527
chr5173053057173053228E07335970
chr5173053232173053329E07336145
chr5173053566173053648E07336479
chr5173053836173053903E07336749
chr5173054837173055697E07337750
chr5173055742173055811E07338655
chr5173056112173056200E07339025
chr5173056420173056460E07339333
chr5173056565173056765E07339478
chr5173056802173056962E07339715
chr5173057598173057648E07340511
chr5173057670173058054E07340583
chr5173066817173066889E07349730
chr5172981014172981262E074-35825
chr5172982396172982694E074-34393
chr5172983515172983686E074-33401
chr5172983799172983970E074-33117
chr5172984279172984501E074-32586
chr5172984641172984782E074-32305
chr5172999609172999744E074-17343
chr5173029541173029766E07412454
chr5173031148173031280E07414061
chr5173044366173044492E07427279
chr5173052614173052959E07435527
chr5173053057173053228E07435970
chr5173053232173053329E07436145
chr5173053566173053648E07436479
chr5173053836173053903E07436749
chr5173054837173055697E07437750
chr5173055742173055811E07438655
chr5173056112173056200E07439025
chr5173056420173056460E07439333
chr5173056565173056765E07439478
chr5173056802173056962E07439715
chr5173057598173057648E07440511
chr5172982396172982694E081-34393
chr5173039557173039637E08122470
chr5173039831173039916E08122744
chr5173040111173040252E08123024
chr5173040332173040690E08123245
chr5173054837173055697E08137750
chr5173055742173055811E08138655
chr5173056112173056200E08139025
chr5173056420173056460E08139333
chr5173056565173056765E08139478
chr5173056802173056962E08139715
chr5173057598173057648E08140511
chr5173057670173058054E08140583
chr5173064069173064123E08146982
chr5173064233173064900E08147146
chr5173040332173040690E08223245
chr5173052614173052959E08235527
chr5173054837173055697E08237750
chr5173056802173056962E08239715
chr5173057598173057648E08240511
chr5173057670173058054E08240583










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr5173042799173044150E06725712
chr5173042799173044150E06825712
chr5173042799173044150E06925712
chr5173042799173044150E07025712
chr5173042799173044150E07125712
chr5173042799173044150E07225712
chr5173042799173044150E07325712
chr5173042799173044150E07425712
chr5173042799173044150E08225712