rs137270

Homo sapiens
G>A
None
Check p-value
SNV (Single Nucleotide Variation)
A=0079 (2388/29922,GnomAD)
A=0089 (2606/29114,TOPMED)
A=0087 (434/5008,1000G)
A=0075 (290/3854,ALSPAC)
A=0081 (299/3708,TWINSUK)
chr22:34771592 (GRCh38.p7) (22q12.3)
ND
GWASdb2
1   publication(s)
See rs on genome
50 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 22NC_000022.11:g.34771592G>A
GRCh37.p13 chr 22NC_000022.10:g.35167583G>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.908A=0.092
1000GenomesAmericanSub694G=0.950A=0.050
1000GenomesEast AsianSub1008G=0.854A=0.146
1000GenomesEuropeSub1006G=0.937A=0.063
1000GenomesGlobalStudy-wide5008G=0.913A=0.087
1000GenomesSouth AsianSub978G=0.930A=0.070
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.925A=0.075
The Genome Aggregation DatabaseAfricanSub8716G=0.902A=0.098
The Genome Aggregation DatabaseAmericanSub838G=0.950A=0.050
The Genome Aggregation DatabaseEast AsianSub1602G=0.858A=0.142
The Genome Aggregation DatabaseEuropeSub18464G=0.933A=0.066
The Genome Aggregation DatabaseGlobalStudy-wide29922G=0.920A=0.079
The Genome Aggregation DatabaseOtherSub302G=0.910A=0.090
Trans-Omics for Precision MedicineGlobalStudy-wide29114G=0.910A=0.089
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.919A=0.081
PMID Title Author Journal
20158304A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.Lind PATwin Res Hum Genet

P-Value

SNP ID p-value Traits Study
rs1372702.11E-05alcohol and nictotine co-dependence20158304

eQTL of rs137270 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs137270 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr223517941235179776E06811829
chr223519561235196889E06828029
chr223517773635177805E07010153
chr223517788635177971E07010303
chr223517814035178208E07010557
chr223517892635178976E07011343
chr223517912535179233E07011542
chr223517941235179776E07011829
chr223517990635180171E07012323
chr223518021335180350E07012630
chr223518047935180657E07012896
chr223519561235196889E07028029
chr223519690435196954E07029321
chr223519748435197534E07029901
chr223519781335197863E07030230
chr223519791835197958E07030335
chr223519800735198057E07030424
chr223517941235179776E07111829
chr223519690435196954E07329321
chr223513553035135625E081-31958
chr223513624735136337E081-31246
chr223513892335139040E081-28543
chr223513918135139388E081-28195
chr223517941235179776E08111829
chr223517990635180171E08112323
chr223519147535191537E08123892
chr223519380735195115E08126224
chr223519512035195199E08127537
chr223519525435195320E08127671
chr223519533835195459E08127755
chr223519561235196889E08128029
chr223519690435196954E08129321
chr223519748435197534E08129901
chr223519781335197863E08130230
chr223519791835197958E08130335
chr223519800735198057E08130424
chr223519850935198612E08130926
chr223517912535179233E08211542
chr223517941235179776E08211829
chr223517990635180171E08212323
chr223518021335180350E08212630
chr223519380735195115E08226224
chr223519512035195199E08227537
chr223519525435195320E08227671
chr223519533835195459E08227755
chr223519561235196889E08228029
chr223519690435196954E08229321
chr223519781335197863E08230230
chr223519791835197958E08230335
chr223519800735198057E08230424