rs1392466

Homo sapiens
G>A
None
Check p-value
SNV (Single Nucleotide Variation)
G==0335 (10038/29932,GnomAD)
G==0315 (9179/29118,TOPMED)
G==0427 (2140/5008,1000G)
G==0351 (1352/3854,ALSPAC)
G==0360 (1334/3708,TWINSUK)
chr5:1744369 (GRCh38.p7) (5p15.33)
AD
GWASdb2
1   publication(s)
See rs on genome
22 Enhancers around
2 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.1744369G>A
GRCh37.p13 chr 5NC_000005.9:g.1744484G>A

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.184A=0.816
1000GenomesAmericanSub694G=0.600A=0.400
1000GenomesEast AsianSub1008G=0.567A=0.433
1000GenomesEuropeSub1006G=0.403A=0.597
1000GenomesGlobalStudy-wide5008G=0.427A=0.573
1000GenomesSouth AsianSub978G=0.520A=0.480
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.351A=0.649
The Genome Aggregation DatabaseAfricanSub8704G=0.196A=0.804
The Genome Aggregation DatabaseAmericanSub838G=0.620A=0.380
The Genome Aggregation DatabaseEast AsianSub1620G=0.561A=0.439
The Genome Aggregation DatabaseEuropeSub18468G=0.369A=0.630
The Genome Aggregation DatabaseGlobalStudy-wide29932G=0.335A=0.664
The Genome Aggregation DatabaseOtherSub302G=0.280A=0.720
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.315A=0.684
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.360A=0.640
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs13924660.00055alcohol dependence24277619

eQTL of rs1392466 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1392466 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr517890311789101E07044547
chr517895381790637E07045054
chr517909291790979E07046445
chr517913871791460E07046903
chr517895381790637E07145054
chr517259661726319E081-18165
chr517516931751834E0817209
chr517595621759642E08115078
chr517601831760268E08115699
chr517603991760745E08115915
chr517608291760959E08116345
chr517609961761036E08116512
chr517610961761168E08116612
chr517833521783500E08138868
chr517895381790637E08145054
chr517909291790979E08146445
chr517608291760959E08216345
chr517609961761036E08216512
chr517610961761168E08216612
chr517785191778573E08234035
chr517895381790637E08245054
chr517909291790979E08246445




Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr517251381725920E070-18564
chr517251381725920E082-18564