rs1404697

Homo sapiens
G>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0057 (1721/29958,GnomAD)
C=0051 (1486/29118,TOPMED)
C=0073 (364/5008,1000G)
C=0058 (223/3854,ALSPAC)
C=0058 (215/3708,TWINSUK)
chr7:108904404 (GRCh38.p7) (7q31.1)
ND
GWASCatalog
1   publication(s)
See rs on genome
2 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 7NC_000007.14:g.108904404G>C
GRCh37.p13 chr 7NC_000007.13:g.108544461G>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.962C=0.038
1000GenomesAmericanSub694G=0.940C=0.060
1000GenomesEast AsianSub1008G=0.857C=0.143
1000GenomesEuropeSub1006G=0.940C=0.060
1000GenomesGlobalStudy-wide5008G=0.927C=0.073
1000GenomesSouth AsianSub978G=0.930C=0.070
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.942C=0.058
The Genome Aggregation DatabaseAfricanSub8726G=0.951C=0.049
The Genome Aggregation DatabaseAmericanSub838G=0.960C=0.040
The Genome Aggregation DatabaseEast AsianSub1600G=0.846C=0.154
The Genome Aggregation DatabaseEuropeSub18492G=0.945C=0.054
The Genome Aggregation DatabaseGlobalStudy-wide29958G=0.942C=0.057
The Genome Aggregation DatabaseOtherSub302G=0.970C=0.030
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.949C=0.051
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.942C=0.058
PMID Title Author Journal
22006218Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence.Yoon DHum Genet

P-Value

SNP ID p-value Traits Study
rs14046975.00E-06Fagerstrom test for nicotine dependence22006218
rs14046978.00E-06Heaviness of Smoking Index22006218

eQTL of rs1404697 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1404697 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr7108509407108510013E070-34448
chr7108590838108591098E07046377