rs1426153

Homo sapiens
A>G
PKNOX2 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0239 (7164/29886,GnomAD)
G=0236 (6887/29118,TOPMED)
G=0274 (1372/5008,1000G)
G=0176 (678/3854,ALSPAC)
G=0187 (693/3708,TWINSUK)
chr11:125300743 (GRCh38.p7) (11q24.2)
AD | ND
GWASdb2 | GWASCatalog
5   publication(s)
See rs on genome
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 11NC_000011.10:g.125300743A>G
GRCh37.p13 chr 11NC_000011.9:g.125170639A>G

Gene: PKNOX2, PBX/knotted 1 homeobox 2(plus strand)

Molecule type Change Amino acid[Codon] SO Term
PKNOX2 transcriptNM_022062.2:c.N/AIntron Variant
PKNOX2 transcript variant X5XM_005271642.2:c.N/AIntron Variant
PKNOX2 transcript variant X12XM_006718894.2:c.N/AIntron Variant
PKNOX2 transcript variant X2XM_011542944.2:c.N/AIntron Variant
PKNOX2 transcript variant X6XM_011542945.2:c.N/AIntron Variant
PKNOX2 transcript variant X11XM_011542946.1:c.N/AIntron Variant
PKNOX2 transcript variant X13XM_011542947.2:c.N/AIntron Variant
PKNOX2 transcript variant X2XM_017018110.1:c.N/AIntron Variant
PKNOX2 transcript variant X14XM_017018111.1:c.N/AIntron Variant
PKNOX2 transcript variant X5XM_005271643.2:c.N/AGenic Upstream Transcript Variant
PKNOX2 transcript variant X10XM_017018112.1:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.629G=0.371
1000GenomesAmericanSub694A=0.870G=0.130
1000GenomesEast AsianSub1008A=0.609G=0.391
1000GenomesEuropeSub1006A=0.819G=0.181
1000GenomesGlobalStudy-wide5008A=0.726G=0.274
1000GenomesSouth AsianSub978A=0.780G=0.220
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.824G=0.176
The Genome Aggregation DatabaseAfricanSub8678A=0.680G=0.320
The Genome Aggregation DatabaseAmericanSub836A=0.900G=0.100
The Genome Aggregation DatabaseEast AsianSub1612A=0.602G=0.398
The Genome Aggregation DatabaseEuropeSub18458A=0.803G=0.196
The Genome Aggregation DatabaseGlobalStudy-wide29886A=0.760G=0.239
The Genome Aggregation DatabaseOtherSub302A=0.890G=0.110
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.763G=0.236
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.813G=0.187
PMID Title Author Journal
21703634A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.Wang KSJ Psychiatr Res
23691092Associations of prenatal nicotine exposure and the dopamine related genes ANKK1 and DRD2 to verbal language.Eicher JDPLoS One
21298047The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.Chen XPLoS One
26044620Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction.Reyes-Gibby CCBMC Syst Biol
22488850Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence.Zuo LAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs14261530.000002alcohol and nicotine co-dependence22488850
rs14261530.0000101alcohol dependence21703634

eQTL of rs1426153 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1426153 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr11125124157125124209E067-46430
chr11125124308125124396E067-46243
chr11125124482125124540E067-46099
chr11125124623125124683E067-45956
chr11125125867125126013E067-44626
chr11125126082125126382E067-44257
chr11125126422125126520E067-44119
chr11125126589125126840E067-43799
chr11125127025125127086E067-43553
chr11125127177125127340E067-43299
chr11125127436125127637E067-43002
chr11125131366125134290E067-36349
chr11125134307125134447E067-36192
chr11125154137125154597E067-16042
chr11125154599125154663E067-15976
chr11125154950125155095E067-15544
chr11125155397125155447E067-15192
chr11125155551125155600E067-15039
chr11125155731125156060E067-14579
chr11125156284125156367E067-14272
chr11125156412125156462E067-14177
chr11125156502125156739E067-13900
chr11125156835125156983E067-13656
chr11125157125125158152E067-12487
chr11125184527125185677E06713888
chr11125185752125186058E06715113
chr11125197278125197400E06726639
chr11125197429125197808E06726790
chr11125197863125198089E06727224
chr11125199654125199716E06729015
chr11125199752125199894E06729113
chr11125199945125200053E06729306
chr11125207750125208342E06737111
chr11125208410125209748E06737771
chr11125212818125213118E06742179
chr11125213124125214119E06742485
chr11125214121125214171E06743482
chr11125214301125214364E06743662
chr11125214476125214537E06743837
chr11125214635125214865E06743996
chr11125214900125214954E06744261
chr11125214979125215209E06744340
chr11125215284125216692E06744645
chr11125217879125219083E06747240
chr11125123692125123768E068-46871
chr11125123811125124019E068-46620
chr11125124062125124116E068-46523
chr11125124157125124209E068-46430
chr11125124308125124396E068-46243
chr11125131366125134290E068-36349
chr11125134307125134447E068-36192
chr11125140729125140962E068-29677
chr11125141374125141814E068-28825
chr11125141882125142369E068-28270
chr11125142474125142551E068-28088
chr11125142609125142707E068-27932
chr11125142726125142895E068-27744
chr11125142909125143089E068-27550
chr11125145806125146168E068-24471
chr11125156502125156739E068-13900
chr11125156835125156983E068-13656
chr11125157125125158152E068-12487
chr11125158209125158531E068-12108
chr11125158563125158637E068-12002
chr11125165680125165741E068-4898
chr11125165798125166315E068-4324
chr11125184138125184512E06813499
chr11125184527125185677E06813888
chr11125197278125197400E06826639
chr11125197429125197808E06826790
chr11125200181125200591E06829542
chr11125200614125200781E06829975
chr11125212818125213118E06842179
chr11125213124125214119E06842485
chr11125214121125214171E06843482
chr11125214301125214364E06843662
chr11125214476125214537E06843837
chr11125214635125214865E06843996
chr11125214900125214954E06844261
chr11125214979125215209E06844340
chr11125217879125219083E06847240
chr11125219104125219528E06848465
chr11125131366125134290E069-36349
chr11125141374125141814E069-28825
chr11125141882125142369E069-28270
chr11125159278125159318E069-11321
chr11125184527125185677E06913888
chr11125196971125197021E06926332
chr11125197154125197198E06926515
chr11125197278125197400E06926639
chr11125197429125197808E06926790
chr11125212818125213118E06942179
chr11125213124125214119E06942485
chr11125214121125214171E06943482
chr11125214301125214364E06943662
chr11125214476125214537E06943837
chr11125214635125214865E06943996
chr11125214900125214954E06944261
chr11125214979125215209E06944340
chr11125120887125120955E070-49684
chr11125121173125121440E070-49199
chr11125126422125126520E070-44119
chr11125126589125126840E070-43799
chr11125127025125127086E070-43553
chr11125127177125127340E070-43299
chr11125127436125127637E070-43002
chr11125127752125127839E070-42800
chr11125127924125128109E070-42530
chr11125128163125128343E070-42296
chr11125128357125128457E070-42182
chr11125128558125128627E070-42012
chr11125128634125128904E070-41735
chr11125129144125129194E070-41445
chr11125129198125129238E070-41401
chr11125129567125129729E070-40910
chr11125131366125134290E070-36349
chr11125139844125139930E070-30709
chr11125139967125140082E070-30557
chr11125140111125140218E070-30421
chr11125140313125140435E070-30204
chr11125140493125140543E070-30096
chr11125140729125140962E070-29677
chr11125141374125141814E070-28825
chr11125141882125142369E070-28270
chr11125142474125142551E070-28088
chr11125142609125142707E070-27932
chr11125142726125142895E070-27744
chr11125142909125143089E070-27550
chr11125143235125143299E070-27340
chr11125143305125143345E070-27294
chr11125146352125146431E070-24208
chr11125146644125146738E070-23901
chr11125149513125149598E070-21041
chr11125149752125149824E070-20815
chr11125150029125150118E070-20521
chr11125150133125150183E070-20456
chr11125150402125150461E070-20178
chr11125150463125150564E070-20075
chr11125150698125150752E070-19887
chr11125150858125150902E070-19737
chr11125150937125150994E070-19645
chr11125151060125151110E070-19529
chr11125151259125151402E070-19237
chr11125151570125151647E070-18992
chr11125154137125154597E070-16042
chr11125154599125154663E070-15976
chr11125154950125155095E070-15544
chr11125155397125155447E070-15192
chr11125155551125155600E070-15039
chr11125155731125156060E070-14579
chr11125156284125156367E070-14272
chr11125156412125156462E070-14177
chr11125156502125156739E070-13900
chr11125156835125156983E070-13656
chr11125157125125158152E070-12487
chr11125158209125158531E070-12108
chr11125158563125158637E070-12002
chr11125158912125159014E070-11625
chr11125159278125159318E070-11321
chr11125159472125159529E070-11110
chr11125159602125159652E070-10987
chr11125159703125159789E070-10850
chr11125159903125159947E070-10692
chr11125159997125160304E070-10335
chr11125160388125160543E070-10096
chr11125160575125160629E070-10010
chr11125161069125161151E070-9488
chr11125162463125162552E070-8087
chr11125162738125162839E070-7800
chr11125162967125163017E070-7622
chr11125163243125163339E070-7300
chr11125170592125171566E0700
chr11125173823125173887E0703184
chr11125173896125173950E0703257
chr11125174019125174116E0703380
chr11125174189125174375E0703550
chr11125174429125174517E0703790
chr11125174547125174649E0703908
chr11125183541125184056E07012902
chr11125184138125184512E07013499
chr11125184527125185677E07013888
chr11125185752125186058E07015113
chr11125203480125203777E07032841
chr11125203877125203927E07033238
chr11125204203125204253E07033564
chr11125204280125204330E07033641
chr11125211773125211860E07041134
chr11125212255125212748E07041616
chr11125212818125213118E07042179
chr11125213124125214119E07042485
chr11125214121125214171E07043482
chr11125214635125214865E07043996
chr11125214900125214954E07044261
chr11125214979125215209E07044340
chr11125215284125216692E07044645
chr11125216787125217043E07046148
chr11125217161125217852E07046522
chr11125217879125219083E07047240
chr11125126422125126520E071-44119
chr11125126589125126840E071-43799
chr11125134307125134447E071-36192
chr11125140729125140962E071-29677
chr11125141374125141814E071-28825
chr11125141882125142369E071-28270
chr11125142474125142551E071-28088
chr11125142609125142707E071-27932
chr11125142726125142895E071-27744
chr11125142909125143089E071-27550
chr11125156412125156462E071-14177
chr11125156502125156739E071-13900
chr11125156835125156983E071-13656
chr11125157125125158152E071-12487
chr11125158912125159014E071-11625
chr11125159278125159318E071-11321
chr11125159472125159529E071-11110
chr11125159602125159652E071-10987
chr11125159703125159789E071-10850
chr11125183541125184056E07112902
chr11125184138125184512E07113499
chr11125184527125185677E07113888
chr11125197278125197400E07126639
chr11125197429125197808E07126790
chr11125197863125198089E07127224
chr11125198161125198247E07127522
chr11125212818125213118E07142179
chr11125213124125214119E07142485
chr11125214121125214171E07143482
chr11125214301125214364E07143662
chr11125214476125214537E07143837
chr11125214635125214865E07143996
chr11125214900125214954E07144261
chr11125214979125215209E07144340
chr11125215284125216692E07144645
chr11125124157125124209E072-46430
chr11125124308125124396E072-46243
chr11125124482125124540E072-46099
chr11125125867125126013E072-44626
chr11125126082125126382E072-44257
chr11125126422125126520E072-44119
chr11125131366125134290E072-36349
chr11125134307125134447E072-36192
chr11125149513125149598E072-21041
chr11125157125125158152E072-12487
chr11125165680125165741E072-4898
chr11125165798125166315E072-4324
chr11125172344125172395E0721705
chr11125183541125184056E07212902
chr11125184138125184512E07213499
chr11125184527125185677E07213888
chr11125185752125186058E07215113
chr11125194679125194729E07224040
chr11125197278125197400E07226639
chr11125197429125197808E07226790
chr11125197863125198089E07227224
chr11125198161125198247E07227522
chr11125199654125199716E07229015
chr11125199752125199894E07229113
chr11125199945125200053E07229306
chr11125212818125213118E07242179
chr11125213124125214119E07242485
chr11125214121125214171E07243482
chr11125214301125214364E07243662
chr11125214476125214537E07243837
chr11125214635125214865E07243996
chr11125214900125214954E07244261
chr11125214979125215209E07244340
chr11125215284125216692E07244645
chr11125120887125120955E073-49684
chr11125124062125124116E073-46523
chr11125124157125124209E073-46430
chr11125124308125124396E073-46243
chr11125124482125124540E073-46099
chr11125126082125126382E073-44257
chr11125126422125126520E073-44119
chr11125126589125126840E073-43799
chr11125127025125127086E073-43553
chr11125127177125127340E073-43299
chr11125131147125131207E073-39432
chr11125131366125134290E073-36349
chr11125134307125134447E073-36192
chr11125140111125140218E073-30421
chr11125140313125140435E073-30204
chr11125140493125140543E073-30096
chr11125140729125140962E073-29677
chr11125154599125154663E073-15976
chr11125165680125165741E073-4898
chr11125165798125166315E073-4324
chr11125184138125184512E07313499
chr11125184527125185677E07313888
chr11125185752125186058E07315113
chr11125203480125203777E07332841
chr11125207418125207472E07336779
chr11125207638125207692E07336999
chr11125207750125208342E07337111
chr11125208410125209748E07337771
chr11125211436125211573E07340797
chr11125211773125211860E07341134
chr11125212255125212748E07341616
chr11125212818125213118E07342179
chr11125213124125214119E07342485
chr11125214121125214171E07343482
chr11125214301125214364E07343662
chr11125214476125214537E07343837
chr11125214635125214865E07343996
chr11125214900125214954E07344261
chr11125214979125215209E07344340
chr11125215284125216692E07344645
chr11125216787125217043E07346148
chr11125217161125217852E07346522
chr11125217879125219083E07347240
chr11125219104125219528E07348465
chr11125219642125219919E07349003
chr11125219988125220051E07349349
chr11125131366125134290E074-36349
chr11125141374125141814E074-28825
chr11125141882125142369E074-28270
chr11125212818125213118E07442179
chr11125213124125214119E07442485
chr11125214121125214171E07443482
chr11125214301125214364E07443662
chr11125214476125214537E07443837
chr11125214635125214865E07443996
chr11125214900125214954E07444261
chr11125214979125215209E07444340
chr11125120887125120955E081-49684
chr11125131366125134290E081-36349
chr11125149513125149598E081-21041
chr11125149752125149824E081-20815
chr11125150029125150118E081-20521
chr11125150133125150183E081-20456
chr11125150402125150461E081-20178
chr11125150463125150564E081-20075
chr11125150698125150752E081-19887
chr11125150858125150902E081-19737
chr11125150937125150994E081-19645
chr11125151060125151110E081-19529
chr11125151259125151402E081-19237
chr11125157125125158152E081-12487
chr11125158209125158531E081-12108
chr11125158563125158637E081-12002
chr11125165186125165250E081-5389
chr11125165300125165382E081-5257
chr11125165409125165486E081-5153
chr11125165680125165741E081-4898
chr11125165798125166315E081-4324
chr11125170592125171566E0810
chr11125173170125173361E0812531
chr11125173572125173622E0812933
chr11125173744125173794E0813105
chr11125173823125173887E0813184
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chr11125174019125174116E0813380
chr11125174189125174375E0813550
chr11125174429125174517E0813790
chr11125174547125174649E0813908
chr11125174680125174773E0814041
chr11125174992125175042E0814353
chr11125184138125184512E08113499
chr11125184527125185677E08113888
chr11125185752125186058E08115113
chr11125200614125200781E08129975
chr11125200841125200933E08130202
chr11125203480125203777E08132841
chr11125208410125209748E08137771
chr11125209750125209946E08139111
chr11125211436125211573E08140797
chr11125211773125211860E08141134
chr11125212255125212748E08141616
chr11125212818125213118E08142179
chr11125213124125214119E08142485
chr11125214121125214171E08143482
chr11125214301125214364E08143662
chr11125214476125214537E08143837
chr11125214635125214865E08143996
chr11125214900125214954E08144261
chr11125214979125215209E08144340
chr11125215284125216692E08144645
chr11125216787125217043E08146148
chr11125217161125217852E08146522
chr11125217879125219083E08147240
chr11125219104125219528E08148465
chr11125219642125219919E08149003
chr11125219988125220051E08149349
chr11125220100125220150E08149461
chr11125220203125220294E08149564
chr11125220404125220571E08149765
chr11125120887125120955E082-49684
chr11125121173125121440E082-49199
chr11125128558125128627E082-42012
chr11125149513125149598E082-21041
chr11125149752125149824E082-20815
chr11125150029125150118E082-20521
chr11125150133125150183E082-20456
chr11125150402125150461E082-20178
chr11125150463125150564E082-20075
chr11125154137125154597E082-16042
chr11125154599125154663E082-15976
chr11125154950125155095E082-15544
chr11125157125125158152E082-12487
chr11125159472125159529E082-11110
chr11125173572125173622E0822933
chr11125173744125173794E0823105
chr11125173823125173887E0823184
chr11125173896125173950E0823257
chr11125184138125184512E08213499
chr11125184527125185677E08213888
chr11125194679125194729E08224040
chr11125194772125194850E08224133
chr11125194965125195005E08224326
chr11125195168125195570E08224529
chr11125212255125212748E08241616
chr11125212818125213118E08242179
chr11125213124125214119E08242485
chr11125214121125214171E08243482
chr11125214301125214364E08243662
chr11125214476125214537E08243837
chr11125214635125214865E08243996
chr11125214900125214954E08244261
chr11125214979125215209E08244340
chr11125215284125216692E08244645