rs1431659

Homo sapiens
A>G
LOC105375897 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A==0264 (7903/29930,GnomAD)
A==0257 (7487/29118,TOPMED)
A==0280 (1402/5008,1000G)
A==0277 (1068/3854,ALSPAC)
A==0268 (994/3708,TWINSUK)
chr8:72526835 (GRCh38.p7) (8q21.11)
AD
GWASdb2
2   publication(s)
See rs on genome
27 Enhancers around
36 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.72526835A>G
GRCh37.p13 chr 8NC_000008.10:g.73439070A>G

Gene: LOC105375897, uncharacterized LOC105375897(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105375897 transcriptXR_929042.2:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.266G=0.734
1000GenomesAmericanSub694A=0.180G=0.820
1000GenomesEast AsianSub1008A=0.315G=0.685
1000GenomesEuropeSub1006A=0.278G=0.722
1000GenomesGlobalStudy-wide5008A=0.280G=0.720
1000GenomesSouth AsianSub978A=0.340G=0.660
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.277G=0.723
The Genome Aggregation DatabaseAfricanSub8710A=0.261G=0.739
The Genome Aggregation DatabaseAmericanSub838A=0.180G=0.820
The Genome Aggregation DatabaseEast AsianSub1614A=0.300G=0.700
The Genome Aggregation DatabaseEuropeSub18468A=0.266G=0.733
The Genome Aggregation DatabaseGlobalStudy-wide29930A=0.264G=0.736
The Genome Aggregation DatabaseOtherSub300A=0.250G=0.750
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.257G=0.742
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.268G=0.732
PMID Title Author Journal
18676988A high-density association screen of 155 ion transport genes for involvement with common migraine.Nyholt DRHum Mol Genet
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs14316590.000387alcohol dependence21314694

eQTL of rs1431659 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1431659 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr87348512473485212E06946054
chr87348525173485373E06946181
chr87348550873485793E06946438
chr87345483973455027E07015769
chr87345508973455169E07016019
chr87348550873485793E07146438
chr87348512473485212E07246054
chr87348525173485373E07246181
chr87348550873485793E07246438
chr87348424973484312E07345179
chr87348434173484825E07345271
chr87348512473485212E07346054
chr87348525173485373E07346181
chr87348550873485793E07346438
chr87348512473485212E07446054
chr87348525173485373E07446181
chr87348550873485793E07446438
chr87348300173483167E08143931
chr87348424973484312E08145179
chr87348434173484825E08145271
chr87348512473485212E08146054
chr87348525173485373E08146181
chr87348550873485793E08146438
chr87348434173484825E08245271
chr87348512473485212E08246054
chr87348525173485373E08246181
chr87348550873485793E08246438








Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr87344831073450782E0679240
chr87345089373450943E06711823
chr87345119273451252E06712122
chr87345152573451619E06712455
chr87345166073451722E06712590
chr87345178173451864E06712711
chr87344831073450782E0689240
chr87345089373450943E06811823
chr87344831073450782E0699240
chr87345089373450943E06911823
chr87344831073450782E0709240
chr87345089373450943E07011823
chr87345119273451252E07012122
chr87345152573451619E07012455
chr87345166073451722E07012590
chr87345178173451864E07012711
chr87344831073450782E0719240
chr87344831073450782E0729240
chr87345089373450943E07211823
chr87345119273451252E07212122
chr87345152573451619E07212455
chr87345166073451722E07212590
chr87345178173451864E07212711
chr87344831073450782E0739240
chr87345089373450943E07311823
chr87345119273451252E07312122
chr87345152573451619E07312455
chr87344831073450782E0749240
chr87344831073450782E0819240
chr87345089373450943E08111823
chr87344831073450782E0829240
chr87345089373450943E08211823
chr87345119273451252E08212122
chr87345152573451619E08212455
chr87345166073451722E08212590
chr87345178173451864E08212711