rs1433375

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
T==0450 (13483/29906,GnomAD)
T==0415 (12090/29118,TOPMED)
T==0417 (2086/5008,1000G)
C=0409 (1577/3854,ALSPAC)
C=0411 (1523/3708,TWINSUK)
chr4:129416904 (GRCh38.p7) (4q28.2)
AD
GWASCatalog
2   publication(s)
See rs on genome
18 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.129416904T>C
GRCh37.p13 chr 4NC_000004.11:g.130338059T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.116C=0.884
1000GenomesAmericanSub694T=0.660C=0.340
1000GenomesEast AsianSub1008T=0.344C=0.656
1000GenomesEuropeSub1006T=0.571C=0.429
1000GenomesGlobalStudy-wide5008T=0.417C=0.583
1000GenomesSouth AsianSub978T=0.560C=0.440
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.591C=0.409
The Genome Aggregation DatabaseAfricanSub8710T=0.185C=0.815
The Genome Aggregation DatabaseAmericanSub838T=0.630C=0.370
The Genome Aggregation DatabaseEast AsianSub1594T=0.358C=0.642
The Genome Aggregation DatabaseEuropeSub18462T=0.574C=0.425
The Genome Aggregation DatabaseGlobalStudy-wide29906T=0.450C=0.549
The Genome Aggregation DatabaseOtherSub302T=0.560C=0.440
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.415C=0.584
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.589C=0.411
PMID Title Author Journal
29082582Problematic alcohol use associates with sodium channel and clathrin linker 1 (SCLT1) in trauma-exposed populations.Almli LMAddict Biol
18237385Robust SNP genotyping by multiplex PCR and arrayed primer extension.Podder MBMC Med Genomics

P-Value

SNP ID p-value Traits Study
rs14333753E-08alcohol dependence29082582

eQTL of rs1433375 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1433375 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr4130325760130326103E067-11956
chr4130351367130351503E07013308
chr4130351554130351807E07013495
chr4130374321130374566E07036262
chr4130374610130375239E07036551
chr4130375967130376139E07037908
chr4130376719130376951E07038660
chr4130377672130377877E07039613
chr4130325760130326103E074-11956
chr4130351367130351503E08113308
chr4130351554130351807E08113495
chr4130374610130375239E08136551
chr4130375967130376139E08137908
chr4130376719130376951E08138660
chr4130374321130374566E08236262
chr4130374610130375239E08236551
chr4130375967130376139E08237908
chr4130376719130376951E08238660