rs1437396

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0174 (5071/29116,TOPMED)
T=0333 (6013/18036,GnomAD)
T=0213 (1066/5008,1000G)
T=0244 (942/3854,ALSPAC)
T=0244 (903/3708,TWINSUK)
chr2:55278320 (GRCh38.p7) (2p16.1)
AD
GWASCatalog
1   publication(s)
See rs on genome
41 Enhancers around
40 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 2NC_000002.12:g.55278320C>T
GRCh37.p13 chr 2NC_000002.11:g.55505456C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.918T=0.082
1000GenomesAmericanSub694C=0.810T=0.190
1000GenomesEast AsianSub1008C=0.533T=0.467
1000GenomesEuropeSub1006C=0.798T=0.202
1000GenomesGlobalStudy-wide5008C=0.787T=0.213
1000GenomesSouth AsianSub978C=0.840T=0.160
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.756T=0.244
The Genome Aggregation DatabaseAfricanSub3850C=0.775T=0.225
The Genome Aggregation DatabaseAmericanSub468C=0.670T=0.330
The Genome Aggregation DatabaseEast AsianSub1352C=0.430T=0.570
The Genome Aggregation DatabaseEuropeSub12158C=0.655T=0.344
The Genome Aggregation DatabaseGlobalStudy-wide18036C=0.666T=0.333
The Genome Aggregation DatabaseOtherSub208C=0.830T=0.170
Trans-Omics for Precision MedicineGlobalStudy-wide29116C=0.825T=0.174
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.756T=0.244
PMID Title Author Journal
24166409Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.Gelernter JMol Psychiatry

P-Value

SNP ID p-value Traits Study
rs14373961.00E-10alcohol dependence24166409
rs14373962.00E-06alcohol dependence24166409
rs14373966.00E-06alcohol dependence24166409

eQTL of rs1437396 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1437396 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr25552201855522068E06716562
chr25552257055522634E06717114
chr25552363655523690E06718180
chr25545561555455699E068-49757
chr25545794855458002E068-47454
chr25545815655458196E068-47260
chr25551056655510715E0685110
chr25551075255510953E0685296
chr25551448655514541E0689030
chr25551867555518744E06813219
chr25552201855522068E06816562
chr25552257055522634E06817114
chr25545561555455699E069-49757
chr25546162855461769E069-43687
chr25546187055461928E069-43528
chr25552201855522068E06916562
chr25552257055522634E06917114
chr25546105055461139E070-44317
chr25546162855461769E070-43687
chr25546187055461928E070-43528
chr25553257955532655E07027123
chr25545561555455699E071-49757
chr25546105055461139E071-44317
chr25546162855461769E071-43687
chr25546187055461928E071-43528
chr25551075255510953E0715296
chr25552201855522068E07116562
chr25552257055522634E07117114
chr25546105055461139E072-44317
chr25546162855461769E072-43687
chr25552201855522068E07216562
chr25552257055522634E07217114
chr25546105055461139E073-44317
chr25551075255510953E0735296
chr25552201855522068E07316562
chr25552257055522634E07317114
chr25552201855522068E07416562
chr25552257055522634E07417114
chr25553213655532385E07426680
chr25546162855461769E081-43687
chr25546355255463855E082-41601










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr25545859155460762E067-44694
chr25549557255497201E067-8255
chr25550885355508964E0673397
chr25550897355510061E0673517
chr25545859155460762E068-44694
chr25549557255497201E068-8255
chr25550885355508964E0683397
chr25550897355510061E0683517
chr25545859155460762E069-44694
chr25549557255497201E069-8255
chr25550885355508964E0693397
chr25550897355510061E0693517
chr25545859155460762E070-44694
chr25549557255497201E070-8255
chr25550655055506742E0701094
chr25550681055506960E0701354
chr25550885355508964E0703397
chr25550897355510061E0703517
chr25545859155460762E071-44694
chr25549557255497201E071-8255
chr25550885355508964E0713397
chr25550897355510061E0713517
chr25545859155460762E072-44694
chr25549557255497201E072-8255
chr25550885355508964E0723397
chr25550897355510061E0723517
chr25545859155460762E073-44694
chr25549557255497201E073-8255
chr25550885355508964E0733397
chr25550897355510061E0733517
chr25545859155460762E074-44694
chr25549557255497201E074-8255
chr25550885355508964E0743397
chr25550897355510061E0743517
chr25549557255497201E081-8255
chr25550897355510061E0813517
chr25545859155460762E082-44694
chr25549557255497201E082-8255
chr25550885355508964E0823397
chr25550897355510061E0823517