rs1449679

Homo sapiens
G>A
LOC101928923 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G==0362 (10843/29906,GnomAD)
G==0339 (9894/29118,TOPMED)
G==0353 (1766/5008,1000G)
G==0455 (1754/3854,ALSPAC)
G==0447 (1657/3708,TWINSUK)
chr6:156014355 (GRCh38.p7) (6q25.3)
AD
GWASdb2
1   publication(s)
See rs on genome
48 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 6NC_000006.12:g.156014355G>A
GRCh37.p13 chr 6NC_000006.11:g.156335489G>A

Gene: LOC101928923, uncharacterized LOC101928923(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC101928923 transcriptXR_001744423.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.188A=0.812
1000GenomesAmericanSub694G=0.420A=0.580
1000GenomesEast AsianSub1008G=0.394A=0.606
1000GenomesEuropeSub1006G=0.476A=0.524
1000GenomesGlobalStudy-wide5008G=0.353A=0.647
1000GenomesSouth AsianSub978G=0.360A=0.640
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.455A=0.545
The Genome Aggregation DatabaseAfricanSub8704G=0.228A=0.772
The Genome Aggregation DatabaseAmericanSub836G=0.440A=0.560
The Genome Aggregation DatabaseEast AsianSub1606G=0.438A=0.562
The Genome Aggregation DatabaseEuropeSub18458G=0.415A=0.584
The Genome Aggregation DatabaseGlobalStudy-wide29906G=0.362A=0.637
The Genome Aggregation DatabaseOtherSub302G=0.400A=0.600
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.339A=0.660
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.447A=0.553
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs14496790.00041alcohol consumption (maxi-drinks)24277619

eQTL of rs1449679 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1449679 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr6156296440156296829E068-38660
chr6156307533156307618E069-27871
chr6156289937156290000E070-45489
chr6156290073156290190E070-45299
chr6156290216156290358E070-45131
chr6156306232156306286E070-29203
chr6156306305156306529E070-28960
chr6156306543156306686E070-28803
chr6156306735156307433E070-28056
chr6156313897156314207E070-21282
chr6156314295156314360E070-21129
chr6156314372156314477E070-21012
chr6156314480156314873E070-20616
chr6156334769156334819E070-670
chr6156334930156335000E070-489
chr6156348949156349098E07013460
chr6156367559156367649E07032070
chr6156368243156368293E07032754
chr6156368390156368430E07032901
chr6156368757156368891E07033268
chr6156369009156369139E07033520
chr6156369221156369275E07033732
chr6156369328156369378E07033839
chr6156369458156369508E07033969
chr6156369649156369732E07034160
chr6156305196156305246E081-30243
chr6156306232156306286E081-29203
chr6156306305156306529E081-28960
chr6156306543156306686E081-28803
chr6156306735156307433E081-28056
chr6156307533156307618E081-27871
chr6156307747156307874E081-27615
chr6156313737156313846E081-21643
chr6156313897156314207E081-21282
chr6156314295156314360E081-21129
chr6156314372156314477E081-21012
chr6156314480156314873E081-20616
chr6156349272156349328E08113783
chr6156366589156367384E08131100
chr6156367559156367649E08132070
chr6156306232156306286E082-29203
chr6156306305156306529E082-28960
chr6156306543156306686E082-28803
chr6156306735156307433E082-28056
chr6156307533156307618E082-27871
chr6156307747156307874E082-27615
chr6156366589156367384E08231100
chr6156369009156369139E08233520