rs1451240

Homo sapiens
A>G
None
Check p-value
SNV (Single Nucleotide Variation)
A==0348 (10441/29926,GnomAD)
A==0423 (12330/29118,TOPMED)
A==0369 (1849/5008,1000G)
A==0224 (862/3854,ALSPAC)
A==0232 (861/3708,TWINSUK)
chr8:42691568 (GRCh38.p7) (8p11.21)
ND
GWASdb2 | GWASCatalog
8   publication(s)
See rs on genome
22 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.42691568A>G
GRCh37.p13 chr 8NC_000008.10:g.42546711A>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.713G=0.287
1000GenomesAmericanSub694A=0.300G=0.700
1000GenomesEast AsianSub1008A=0.205G=0.795
1000GenomesEuropeSub1006A=0.223G=0.777
1000GenomesGlobalStudy-wide5008A=0.369G=0.631
1000GenomesSouth AsianSub978A=0.270G=0.730
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.224G=0.776
The Genome Aggregation DatabaseAfricanSub8708A=0.652G=0.348
The Genome Aggregation DatabaseAmericanSub838A=0.250G=0.750
The Genome Aggregation DatabaseEast AsianSub1620A=0.184G=0.816
The Genome Aggregation DatabaseEuropeSub18458A=0.226G=0.773
The Genome Aggregation DatabaseGlobalStudy-wide29926A=0.348G=0.651
The Genome Aggregation DatabaseOtherSub302A=0.260G=0.740
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.423G=0.576
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.232G=0.768
PMID Title Author Journal
25642160Nicotinic receptor modulation to treat alcohol and drug dependence.Rahman SFront Neurosci
26044620Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction.Reyes-Gibby CCBMC Syst Biol
23943838Effect of neuronal nicotinic acetylcholine receptor genes (CHRN) on longitudinal cigarettes per day in adolescents and young adults.Cannon DSNicotine Tob Res
27166759Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions.Yang JMol Psychiatry
27327258Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research.Wen LTransl Psychiatry
25770649Are genetic variants for tobacco smoking associated with cannabis involvement?Agrawal ADrug Alcohol Depend
22524403CHRNB3 is more strongly associated with Fagerstrom test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies results.Rice JPAddiction
27050379Genetic variants of CHRNA5-A3 and CHRNB3-A6 predict survival of patients with advanced non-small cell lung cancer.Wang YOncotarget

P-Value

SNP ID p-value Traits Study
rs14512407E-16nicotine dependence22524403

eQTL of rs1451240 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1451240 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr84255878642559348E06712075
chr84255950742559557E06712796
chr84255956442559738E06712853
chr84255978342560036E06713072
chr84257551642576584E06928805
chr84255878642559348E07112075
chr84255950742559557E07112796
chr84255956442559738E07112853
chr84257551642576584E07128805
chr84254736742548251E072656
chr84257551642576584E07228805
chr84257551642576584E07328805
chr84255878642559348E07412075
chr84255950742559557E07412796
chr84255956442559738E07412853
chr84255978342560036E07413072
chr84256031142560370E07413600
chr84257551642576584E07428805
chr84251152842512118E081-34593
chr84256031142560370E08113600
chr84256054542560595E08113834
chr84256060442560725E08113893