Sequence Name | Change(s) |
---|---|
GRCh38.p7 chr 7 | NC_000007.14:g.50485353T>C |
GRCh37.p13 chr 7 | NC_000007.13:g.50553051T>C |
DDC RefSeqGene | NG_008742.1:g.85104A>G |
Molecule type | Change | Amino acid[Codon] | SO Term |
---|---|---|---|
DDC transcript variant 2 | NM_000790.3:c. | N/A | Intron Variant |
DDC transcript variant 1 | NM_001082971.1:c. | N/A | Intron Variant |
DDC transcript variant 3 | NM_001242886.1:c. | N/A | Intron Variant |
DDC transcript variant 4 | NM_001242887.1:c. | N/A | Intron Variant |
DDC transcript variant 5 | NM_001242888.1:c. | N/A | Intron Variant |
DDC transcript variant 6 | NM_001242889.1:c. | N/A | Intron Variant |
DDC transcript variant 7 | NM_001242890.1:c. | N/A | Genic Downstream Transcript Variant |
DDC transcript variant X2 | XM_005271745.4:c. | N/A | Intron Variant |
DDC transcript variant X1 | XM_011515161.2:c. | N/A | Intron Variant |
Study | Population | Group | Sample # | Ref Allele | Alt Allele |
---|---|---|---|---|---|
1000Genomes | African | Sub | 1322 | T=0.710 | C=0.290 |
1000Genomes | American | Sub | 694 | T=0.470 | C=0.530 |
1000Genomes | East Asian | Sub | 1008 | T=0.549 | C=0.451 |
1000Genomes | Europe | Sub | 1006 | T=0.594 | C=0.406 |
1000Genomes | Global | Study-wide | 5008 | T=0.610 | C=0.390 |
1000Genomes | South Asian | Sub | 978 | T=0.650 | C=0.350 |
The Avon Longitudinal Study of Parents and Children | PARENT AND CHILD COHORT | Study-wide | 3854 | T=0.560 | C=0.440 |
The Genome Aggregation Database | African | Sub | 8726 | T=0.712 | C=0.288 |
The Genome Aggregation Database | American | Sub | 838 | T=0.460 | C=0.540 |
The Genome Aggregation Database | East Asian | Sub | 1610 | T=0.570 | C=0.430 |
The Genome Aggregation Database | Europe | Sub | 18450 | T=0.579 | C=0.420 |
The Genome Aggregation Database | Global | Study-wide | 29926 | T=0.613 | C=0.386 |
The Genome Aggregation Database | Other | Sub | 302 | T=0.500 | C=0.500 |
Trans-Omics for Precision Medicine | Global | Study-wide | 29118 | T=0.622 | C=0.377 |
UK 10K study - Twins | TWIN COHORT | Study-wide | 3708 | T=0.562 | C=0.438 |
PMID | Title | Author | Journal |
---|---|---|---|
26044620 | Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction. | Reyes-Gibby CC | BMC Syst Biol |
19221445 | Tyrosine hydroxylase and DOPA decarboxylase gene variants in personality traits. | Giegling I | Neuropsychobiology |
17184203 | DOPA decarboxylase gene is associated with nicotine dependence. | Zhang H | Pharmacogenomics |
15879433 | Haplotype analysis indicates an association between the DOPA decarboxylase (DDC) gene and nicotine dependence. | Ma JZ | Hum Mol Genet |
17948905 | Dopa decarboxylase and tyrosine hydroxylase gene variants in suicidal behavior. | Giegling I | Am J Med Genet B Neuropsychiatr Genet |
SNP ID | p-value | Traits | Study |
---|---|---|---|
rs1451371 | 0.001 | Drug response to nicotine | 15879433 |
Position (v37) | eGene | GeneID | Variant | p-value | TSS | Tissue |
---|---|---|---|---|---|---|
Chr7:50553051 | FIGNL1 | ENSG00000132436.7 | T>C | 1.0000e-28 | 34963 | Cerebellum |
Chr7:50553051 | FIGNL1 | ENSG00000132436.7 | T>C | 1.5775e-13 | 34963 | Frontal_Cortex_BA9 |
Chr7:50553051 | FIGNL1 | ENSG00000132436.7 | T>C | 4.8760e-13 | 34963 | Cortex |
Chr7:50553051 | FIGNL1 | ENSG00000132436.7 | T>C | 1.4382e-22 | 34963 | Cerebellar_Hemisphere |
Chr7:50553051 | FIGNL1 | ENSG00000132436.7 | T>C | 1.0286e-8 | 34963 | Caudate_basal_ganglia |
Chr7:50553051 | FIGNL1 | ENSG00000132436.7 | T>C | 5.5405e-6 | 34963 | Hippocampus |
Chr7:50553051 | FIGNL1 | ENSG00000132436.7 | T>C | 9.4277e-6 | 34963 | Putamen_basal_ganglia |
Chr7:50553051 | FIGNL1 | ENSG00000132436.7 | T>C | 1.3261e-8 | 34963 | Anterior_cingulate_cortex |
Chr7:50553051 | FIGNL1 | ENSG00000132436.7 | T>C | 3.1156e-7 | 34963 | Nucleus_accumbens_basal_ganglia |
Chr7:50553051 | FIGNL1 | ENSG00000132436.7 | T>C | 2.3548e-9 | 34963 | Amygdala |
Probe ID | Position | Gene | beta | p-value |
---|---|---|---|---|
cg18232548 | chr7:50535776 | DDC | -0.00969285533423492 | 1.0874e-10 |
There is no significant Hi-C chromatin interaction data for this SNP.
Chromosome | Start | End | Region | Distance ( -/+ : Up/Downstream ) |
---|---|---|---|---|
chr7 | 50516878 | 50516928 | E067 | -36123 |
chr7 | 50516967 | 50517051 | E067 | -36000 |
chr7 | 50536378 | 50536524 | E067 | -16527 |
chr7 | 50598960 | 50599691 | E067 | 45909 |
chr7 | 50599710 | 50599919 | E067 | 46659 |
chr7 | 50599948 | 50600033 | E067 | 46897 |
chr7 | 50600073 | 50600144 | E067 | 47022 |
chr7 | 50516878 | 50516928 | E068 | -36123 |
chr7 | 50516967 | 50517051 | E068 | -36000 |
chr7 | 50536378 | 50536524 | E068 | -16527 |
chr7 | 50536534 | 50536642 | E068 | -16409 |
chr7 | 50602342 | 50602965 | E068 | 49291 |
chr7 | 50536378 | 50536524 | E069 | -16527 |
chr7 | 50599710 | 50599919 | E069 | 46659 |
chr7 | 50599948 | 50600033 | E069 | 46897 |
chr7 | 50600073 | 50600144 | E069 | 47022 |
chr7 | 50534666 | 50534741 | E070 | -18310 |
chr7 | 50534765 | 50534875 | E070 | -18176 |
chr7 | 50534944 | 50535196 | E070 | -17855 |
chr7 | 50535212 | 50535305 | E070 | -17746 |
chr7 | 50535469 | 50536370 | E070 | -16681 |
chr7 | 50595823 | 50595915 | E070 | 42772 |
chr7 | 50595987 | 50596159 | E070 | 42936 |
chr7 | 50598960 | 50599691 | E070 | 45909 |
chr7 | 50600073 | 50600144 | E070 | 47022 |
chr7 | 50536378 | 50536524 | E071 | -16527 |
chr7 | 50536378 | 50536524 | E072 | -16527 |
chr7 | 50535469 | 50536370 | E073 | -16681 |
chr7 | 50536378 | 50536524 | E073 | -16527 |
chr7 | 50516967 | 50517051 | E074 | -36000 |
chr7 | 50535469 | 50536370 | E074 | -16681 |
chr7 | 50536378 | 50536524 | E074 | -16527 |
chr7 | 50535212 | 50535305 | E081 | -17746 |
chr7 | 50535469 | 50536370 | E081 | -16681 |
chr7 | 50598960 | 50599691 | E081 | 45909 |
chr7 | 50599710 | 50599919 | E081 | 46659 |
chr7 | 50599948 | 50600033 | E081 | 46897 |
Chromosome | Start | End | Region | Distance(-/+:Up/Downstream) |
---|---|---|---|---|
chr7 | 50517249 | 50519075 | E067 | -33976 |
chr7 | 50517249 | 50519075 | E068 | -33976 |
chr7 | 50517249 | 50519075 | E069 | -33976 |
chr7 | 50517249 | 50519075 | E070 | -33976 |
chr7 | 50517249 | 50519075 | E071 | -33976 |
chr7 | 50517249 | 50519075 | E072 | -33976 |
chr7 | 50517249 | 50519075 | E073 | -33976 |
chr7 | 50517249 | 50519075 | E074 | -33976 |
chr7 | 50517249 | 50519075 | E081 | -33976 |
chr7 | 50517249 | 50519075 | E082 | -33976 |