rs1451722

Homo sapiens
C>T
RHOG : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0476 (14229/29874,GnomAD)
T=0436 (12721/29118,TOPMED)
T=0453 (2270/5008,1000G)
C==0446 (1720/3854,ALSPAC)
C==0441 (1636/3708,TWINSUK)
chr11:3835323 (GRCh38.p7) (11p15.4)
AD
GWASdb2
1   publication(s)
See rs on genome
336 Enhancers around
36 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 11NC_000011.10:g.3835323C>T
GRCh37.p13 chr 11NC_000011.9:g.3856553C>T

Gene: RHOG, ras homolog family member G(minus strand)

Molecule type Change Amino acid[Codon] SO Term
RHOG transcriptNM_001665.3:c.N/AIntron Variant
RHOG transcript variant X1XM_005252916.2:c.N/AIntron Variant
RHOG transcript variant X2XM_017017719.1:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.819T=0.181
1000GenomesAmericanSub694C=0.480T=0.520
1000GenomesEast AsianSub1008C=0.465T=0.535
1000GenomesEuropeSub1006C=0.430T=0.570
1000GenomesGlobalStudy-wide5008C=0.547T=0.453
1000GenomesSouth AsianSub978C=0.430T=0.570
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.446T=0.554
The Genome Aggregation DatabaseAfricanSub8704C=0.746T=0.254
The Genome Aggregation DatabaseAmericanSub836C=0.440T=0.560
The Genome Aggregation DatabaseEast AsianSub1608C=0.476T=0.524
The Genome Aggregation DatabaseEuropeSub18424C=0.426T=0.573
The Genome Aggregation DatabaseGlobalStudy-wide29874C=0.523T=0.476
The Genome Aggregation DatabaseOtherSub302C=0.530T=0.470
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.563T=0.436
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.441T=0.559
PMID Title Author Journal
23089632A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53.Wang JCMol Psychiatry

P-Value

SNP ID p-value Traits Study
rs14517224.35E-06alcohol dependence23089632

eQTL of rs1451722 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1451722 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr1138078943808458E067-48095
chr1138158333815934E067-40619
chr1138160453816125E067-40428
chr1138164003816450E067-40103
chr1138440793844129E067-12424
chr1138441303844218E067-12335
chr1138444853845151E067-11402
chr1138452263845424E067-11129
chr1138454323845609E067-10944
chr1138457313845860E067-10693
chr1138458673846970E067-9583
chr1138470113847081E067-9472
chr1138470993847373E067-9180
chr1138476033847675E067-8878
chr1138477363848546E067-8007
chr1138485983848687E067-7866
chr1138487093848835E067-7718
chr1138488663848916E067-7637
chr1138489803849030E067-7523
chr1138491193849163E067-7390
chr1138491793849413E067-7140
chr1138494713849617E067-6936
chr1138526553852778E067-3775
chr1138527883852877E067-3676
chr1138529363853245E067-3308
chr1138532813853478E067-3075
chr1138535043853886E067-2667
chr1138539393854003E067-2550
chr1138540453854095E067-2458
chr1138541123854271E067-2282
chr1138546263854666E067-1887
chr1138556013856883E0670
chr1138568963857327E067343
chr1138576093857849E0671056
chr1138579953858045E0671442
chr1138581773858982E0671624
chr1138589843859431E0672431
chr1138594823859585E0672929
chr1138795983879814E06723045
chr1138798643880133E06723311
chr1138801443880528E06723591
chr1138811813881307E06724628
chr1138813573881403E06724804
chr1138865493886692E06729996
chr1138867023886770E06730149
chr1138071523807248E068-49305
chr1138073343807479E068-49074
chr1138074833807563E068-48990
chr1138076613807701E068-48852
chr1138078943808458E068-48095
chr1138086293808754E068-47799
chr1138087833808976E068-47577
chr1138318203832542E068-24011
chr1138325853832692E068-23861
chr1138444853845151E068-11402
chr1138452263845424E068-11129
chr1138454323845609E068-10944
chr1138457313845860E068-10693
chr1138458673846970E068-9583
chr1138470113847081E068-9472
chr1138470993847373E068-9180
chr1138476033847675E068-8878
chr1138477363848546E068-8007
chr1138485983848687E068-7866
chr1138487093848835E068-7718
chr1138488663848916E068-7637
chr1138489803849030E068-7523
chr1138491193849163E068-7390
chr1138491793849413E068-7140
chr1138494713849617E068-6936
chr1138496763849721E068-6832
chr1138497273849781E068-6772
chr1138519573852003E068-4550
chr1138520473852237E068-4316
chr1138522953852353E068-4200
chr1138525483852588E068-3965
chr1138526553852778E068-3775
chr1138527883852877E068-3676
chr1138529363853245E068-3308
chr1138532813853478E068-3075
chr1138535043853886E068-2667
chr1138539393854003E068-2550
chr1138540453854095E068-2458
chr1138541123854271E068-2282
chr1138546263854666E068-1887
chr1138547793854931E068-1622
chr1138549833855068E068-1485
chr1138551833855243E068-1310
chr1138556013856883E0680
chr1138568963857327E068343
chr1138576093857849E0681056
chr1138579953858045E0681442
chr1138581773858982E0681624
chr1138795983879814E06823045
chr1138798643880133E06823311
chr1138811813881307E06824628
chr1138829013882953E06826348
chr1138865493886692E06829996
chr1138867023886770E06830149
chr1138868613887784E06830308
chr1138882293888306E06831676
chr1138884503889525E06831897
chr1138985403899370E06841987
chr1139019583902296E06845405
chr1138073343807479E069-49074
chr1138074833807563E069-48990
chr1138076613807701E069-48852
chr1138078943808458E069-48095
chr1138160453816125E069-40428
chr1138164003816450E069-40103
chr1138444853845151E069-11402
chr1138452263845424E069-11129
chr1138458673846970E069-9583
chr1138470113847081E069-9472
chr1138470993847373E069-9180
chr1138476033847675E069-8878
chr1138491193849163E069-7390
chr1138491793849413E069-7140
chr1138494713849617E069-6936
chr1138496763849721E069-6832
chr1138497273849781E069-6772
chr1138517823851838E069-4715
chr1138519573852003E069-4550
chr1138520473852237E069-4316
chr1138522953852353E069-4200
chr1138525483852588E069-3965
chr1138526553852778E069-3775
chr1138527883852877E069-3676
chr1138529363853245E069-3308
chr1138532813853478E069-3075
chr1138535043853886E069-2667
chr1138539393854003E069-2550
chr1138540453854095E069-2458
chr1138541123854271E069-2282
chr1138546263854666E069-1887
chr1138547793854931E069-1622
chr1138549833855068E069-1485
chr1138551833855243E069-1310
chr1138556013856883E0690
chr1138568963857327E069343
chr1138576093857849E0691056
chr1138579953858045E0691442
chr1138581773858982E0691624
chr1138594823859585E0692929
chr1138795983879814E06923045
chr1138798643880133E06923311
chr1138801443880528E06923591
chr1138865493886692E06929996
chr1138867023886770E06930149
chr1138868613887784E06930308
chr1138985403899370E06941987
chr1139019583902296E06945405
chr1138795983879814E07023045
chr1138798643880133E07023311
chr1138801443880528E07023591
chr1138811813881307E07024628
chr1138985403899370E07041987
chr1138071523807248E071-49305
chr1138073343807479E071-49074
chr1138074833807563E071-48990
chr1138076613807701E071-48852
chr1138078943808458E071-48095
chr1138086293808754E071-47799
chr1138444853845151E071-11402
chr1138452263845424E071-11129
chr1138454323845609E071-10944
chr1138457313845860E071-10693
chr1138458673846970E071-9583
chr1138470113847081E071-9472
chr1138470993847373E071-9180
chr1138476033847675E071-8878
chr1138491193849163E071-7390
chr1138491793849413E071-7140
chr1138494713849617E071-6936
chr1138496763849721E071-6832
chr1138497273849781E071-6772
chr1138502753850420E071-6133
chr1138504563850504E071-6049
chr1138507553850810E071-5743
chr1138508263850928E071-5625
chr1138513193851374E071-5179
chr1138515653851634E071-4919
chr1138520473852237E071-4316
chr1138522953852353E071-4200
chr1138525483852588E071-3965
chr1138526553852778E071-3775
chr1138527883852877E071-3676
chr1138529363853245E071-3308
chr1138532813853478E071-3075
chr1138535043853886E071-2667
chr1138539393854003E071-2550
chr1138540453854095E071-2458
chr1138541123854271E071-2282
chr1138546263854666E071-1887
chr1138547793854931E071-1622
chr1138549833855068E071-1485
chr1138551833855243E071-1310
chr1138576093857849E0711056
chr1138579953858045E0711442
chr1138581773858982E0711624
chr1138795983879814E07123045
chr1138798643880133E07123311
chr1138801443880528E07123591
chr1138868613887784E07130308
chr1138884503889525E07131897
chr1138985403899370E07141987
chr1139012143901710E07144661
chr1139019583902296E07145405
chr1138078943808458E072-48095
chr1138444853845151E072-11402
chr1138452263845424E072-11129
chr1138454323845609E072-10944
chr1138457313845860E072-10693
chr1138458673846970E072-9583
chr1138470113847081E072-9472
chr1138470993847373E072-9180
chr1138485983848687E072-7866
chr1138487093848835E072-7718
chr1138488663848916E072-7637
chr1138489803849030E072-7523
chr1138491193849163E072-7390
chr1138491793849413E072-7140
chr1138494713849617E072-6936
chr1138496763849721E072-6832
chr1138497273849781E072-6772
chr1138502753850420E072-6133
chr1138504563850504E072-6049
chr1138507553850810E072-5743
chr1138529363853245E072-3308
chr1138532813853478E072-3075
chr1138535043853886E072-2667
chr1138539393854003E072-2550
chr1138540453854095E072-2458
chr1138541123854271E072-2282
chr1138546263854666E072-1887
chr1138547793854931E072-1622
chr1138549833855068E072-1485
chr1138551833855243E072-1310
chr1138556013856883E0720
chr1138576093857849E0721056
chr1138579953858045E0721442
chr1138581773858982E0721624
chr1138589843859431E0722431
chr1138594823859585E0722929
chr1138801443880528E07223591
chr1138884503889525E07231897
chr1138985403899370E07241987
chr1139019583902296E07245405
chr1138314743831533E073-25020
chr1138458673846970E073-9583
chr1138485983848687E073-7866
chr1138487093848835E073-7718
chr1138488663848916E073-7637
chr1138489803849030E073-7523
chr1138491193849163E073-7390
chr1138491793849413E073-7140
chr1138535043853886E073-2667
chr1138539393854003E073-2550
chr1138540453854095E073-2458
chr1138541123854271E073-2282
chr1138546263854666E073-1887
chr1138547793854931E073-1622
chr1138549833855068E073-1485
chr1138551833855243E073-1310
chr1138556013856883E0730
chr1138568963857327E073343
chr1138576093857849E0731056
chr1138579953858045E0731442
chr1138581773858982E0731624
chr1138589843859431E0732431
chr1138594823859585E0732929
chr1138795983879814E07323045
chr1138798643880133E07323311
chr1138801443880528E07323591
chr1138811813881307E07324628
chr1138863813886432E07329828
chr1138865493886692E07329996
chr1138867023886770E07330149
chr1138868613887784E07330308
chr1139012143901710E07344661
chr1138067853807013E074-49540
chr1138071523807248E074-49305
chr1138073343807479E074-49074
chr1138074833807563E074-48990
chr1138078943808458E074-48095
chr1138444853845151E074-11402
chr1138452263845424E074-11129
chr1138454323845609E074-10944
chr1138458673846970E074-9583
chr1138470113847081E074-9472
chr1138470993847373E074-9180
chr1138476033847675E074-8878
chr1138477363848546E074-8007
chr1138485983848687E074-7866
chr1138487093848835E074-7718
chr1138491193849163E074-7390
chr1138491793849413E074-7140
chr1138494713849617E074-6936
chr1138496763849721E074-6832
chr1138497273849781E074-6772
chr1138502753850420E074-6133
chr1138504563850504E074-6049
chr1138507553850810E074-5743
chr1138508263850928E074-5625
chr1138513193851374E074-5179
chr1138515653851634E074-4919
chr1138517823851838E074-4715
chr1138519573852003E074-4550
chr1138520473852237E074-4316
chr1138522953852353E074-4200
chr1138525483852588E074-3965
chr1138526553852778E074-3775
chr1138527883852877E074-3676
chr1138529363853245E074-3308
chr1138532813853478E074-3075
chr1138535043853886E074-2667
chr1138539393854003E074-2550
chr1138540453854095E074-2458
chr1138541123854271E074-2282
chr1138546263854666E074-1887
chr1138547793854931E074-1622
chr1138549833855068E074-1485
chr1138551833855243E074-1310
chr1138576093857849E0741056
chr1138579953858045E0741442
chr1138581773858982E0741624
chr1138594823859585E0742929
chr1138795983879814E07423045
chr1138798643880133E07423311
chr1138801443880528E07423591
chr1138811813881307E07424628
chr1138884503889525E07431897
chr1138199513820047E081-36506
chr1138201153820208E081-36345
chr1138160453816125E082-40428
chr1138164003816450E082-40103










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr1138173853819636E067-36917
chr1138288533831193E067-25360
chr1138596003863645E0673047
chr1138751483878335E06718595
chr1138173853819636E068-36917
chr1138288533831193E068-25360
chr1138596003863645E0683047
chr1138751483878335E06818595
chr1138173853819636E069-36917
chr1138288533831193E069-25360
chr1138596003863645E0693047
chr1138751483878335E06918595
chr1138173853819636E070-36917
chr1138288533831193E070-25360
chr1138596003863645E0703047
chr1138751483878335E07018595
chr1138173853819636E071-36917
chr1138288533831193E071-25360
chr1138596003863645E0713047
chr1138751483878335E07118595
chr1138173853819636E072-36917
chr1138751483878335E07218595
chr1138173853819636E073-36917
chr1138288533831193E073-25360
chr1138596003863645E0733047
chr1138751483878335E07318595
chr1138173853819636E074-36917
chr1138288533831193E074-25360
chr1138596003863645E0743047
chr1138751483878335E07418595
chr1138173853819636E081-36917
chr1138596003863645E0813047
chr1138173853819636E082-36917
chr1138288533831193E082-25360
chr1138596003863645E0823047
chr1138751483878335E08218595