rs1451724

Organism: Homo sapiens

Alleles: G>A

Gene : Feature

RHOG : Intron Variant

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

A=0402 (12014/29888,GnomAD)
A=0348 (10133/29118,TOPMED)
A=0398 (1994/5008,1000G)
A=0467 (1798/3854,ALSPAC)
A=0464 (1721/3708,TWINSUK)

Position: chr11:3835438 (GRCh38.p7) (11p15.4)

Phenotype: AD

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 336 Enhancers around

Promoter: 36 Promoters around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 11	NC_000011.10:g.3835438G>A
GRCh37.p13 chr 11	NC_000011.9:g.3856668G>A

Gene: RHOG, ras homolog family member G(minus strand)

Molecule type	Change	Amino acid[Codon]	SO Term
RHOG transcript	NM_001665.3:c.	N/A	Intron Variant
RHOG transcript variant X1	XM_005252916.2:c.	N/A	Intron Variant
RHOG transcript variant X2	XM_017017719.1:c.	N/A	Genic Upstream Transcript Variant

Population Frequency

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	G=0.883	A=0.117
1000Genomes	American	Sub	694	G=0.550	A=0.450
1000Genomes	East Asian	Sub	1008	G=0.466	A=0.534
1000Genomes	Europe	Sub	1006	G=0.533	A=0.467
1000Genomes	Global	Study-wide	5008	G=0.602	A=0.398
1000Genomes	South Asian	Sub	978	G=0.470	A=0.530
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	G=0.533	A=0.467
The Genome Aggregation Database	African	Sub	8710	G=0.809	A=0.191
The Genome Aggregation Database	American	Sub	836	G=0.510	A=0.490
The Genome Aggregation Database	East Asian	Sub	1616	G=0.478	A=0.522
The Genome Aggregation Database	Europe	Sub	18424	G=0.512	A=0.487
The Genome Aggregation Database	Global	Study-wide	29888	G=0.598	A=0.402
The Genome Aggregation Database	Other	Sub	302	G=0.610	A=0.390
Trans-Omics for Precision Medicine	Global	Study-wide	29118	G=0.652	A=0.348
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	G=0.536	A=0.464

PMID	Title	Author	Journal
23089632	A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53.	Wang JC	Mol Psychiatry

P-Value

SNP ID	p-value	Traits	Study
rs1451724	6.68E-07	alcohol dependence	23089632

eQTL of rs1451724 in Brain tissues (GTEx Analysis Release V7)

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

meQTL of rs1451724 in Fetal Brain

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr11	3807894	3808458	E067	-48210
chr11	3815833	3815934	E067	-40734
chr11	3816045	3816125	E067	-40543
chr11	3816400	3816450	E067	-40218
chr11	3844079	3844129	E067	-12539
chr11	3844130	3844218	E067	-12450
chr11	3844485	3845151	E067	-11517
chr11	3845226	3845424	E067	-11244
chr11	3845432	3845609	E067	-11059
chr11	3845731	3845860	E067	-10808
chr11	3845867	3846970	E067	-9698
chr11	3847011	3847081	E067	-9587
chr11	3847099	3847373	E067	-9295
chr11	3847603	3847675	E067	-8993
chr11	3847736	3848546	E067	-8122
chr11	3848598	3848687	E067	-7981
chr11	3848709	3848835	E067	-7833
chr11	3848866	3848916	E067	-7752
chr11	3848980	3849030	E067	-7638
chr11	3849119	3849163	E067	-7505
chr11	3849179	3849413	E067	-7255
chr11	3849471	3849617	E067	-7051
chr11	3852655	3852778	E067	-3890
chr11	3852788	3852877	E067	-3791
chr11	3852936	3853245	E067	-3423
chr11	3853281	3853478	E067	-3190
chr11	3853504	3853886	E067	-2782
chr11	3853939	3854003	E067	-2665
chr11	3854045	3854095	E067	-2573
chr11	3854112	3854271	E067	-2397
chr11	3854626	3854666	E067	-2002
chr11	3855601	3856883	E067	0
chr11	3856896	3857327	E067	228
chr11	3857609	3857849	E067	941
chr11	3857995	3858045	E067	1327
chr11	3858177	3858982	E067	1509
chr11	3858984	3859431	E067	2316
chr11	3859482	3859585	E067	2814
chr11	3879598	3879814	E067	22930
chr11	3879864	3880133	E067	23196
chr11	3880144	3880528	E067	23476
chr11	3881181	3881307	E067	24513
chr11	3881357	3881403	E067	24689
chr11	3886549	3886692	E067	29881
chr11	3886702	3886770	E067	30034
chr11	3807152	3807248	E068	-49420
chr11	3807334	3807479	E068	-49189
chr11	3807483	3807563	E068	-49105
chr11	3807661	3807701	E068	-48967
chr11	3807894	3808458	E068	-48210
chr11	3808629	3808754	E068	-47914
chr11	3808783	3808976	E068	-47692
chr11	3831820	3832542	E068	-24126
chr11	3832585	3832692	E068	-23976
chr11	3844485	3845151	E068	-11517
chr11	3845226	3845424	E068	-11244
chr11	3845432	3845609	E068	-11059
chr11	3845731	3845860	E068	-10808
chr11	3845867	3846970	E068	-9698
chr11	3847011	3847081	E068	-9587
chr11	3847099	3847373	E068	-9295
chr11	3847603	3847675	E068	-8993
chr11	3847736	3848546	E068	-8122
chr11	3848598	3848687	E068	-7981
chr11	3848709	3848835	E068	-7833
chr11	3848866	3848916	E068	-7752
chr11	3848980	3849030	E068	-7638
chr11	3849119	3849163	E068	-7505
chr11	3849179	3849413	E068	-7255
chr11	3849471	3849617	E068	-7051
chr11	3849676	3849721	E068	-6947
chr11	3849727	3849781	E068	-6887
chr11	3851957	3852003	E068	-4665
chr11	3852047	3852237	E068	-4431
chr11	3852295	3852353	E068	-4315
chr11	3852548	3852588	E068	-4080
chr11	3852655	3852778	E068	-3890
chr11	3852788	3852877	E068	-3791
chr11	3852936	3853245	E068	-3423
chr11	3853281	3853478	E068	-3190
chr11	3853504	3853886	E068	-2782
chr11	3853939	3854003	E068	-2665
chr11	3854045	3854095	E068	-2573
chr11	3854112	3854271	E068	-2397
chr11	3854626	3854666	E068	-2002
chr11	3854779	3854931	E068	-1737
chr11	3854983	3855068	E068	-1600
chr11	3855183	3855243	E068	-1425
chr11	3855601	3856883	E068	0
chr11	3856896	3857327	E068	228
chr11	3857609	3857849	E068	941
chr11	3857995	3858045	E068	1327
chr11	3858177	3858982	E068	1509
chr11	3879598	3879814	E068	22930
chr11	3879864	3880133	E068	23196
chr11	3881181	3881307	E068	24513
chr11	3882901	3882953	E068	26233
chr11	3886549	3886692	E068	29881
chr11	3886702	3886770	E068	30034
chr11	3886861	3887784	E068	30193
chr11	3888229	3888306	E068	31561
chr11	3888450	3889525	E068	31782
chr11	3898540	3899370	E068	41872
chr11	3901958	3902296	E068	45290
chr11	3807334	3807479	E069	-49189
chr11	3807483	3807563	E069	-49105
chr11	3807661	3807701	E069	-48967
chr11	3807894	3808458	E069	-48210
chr11	3816045	3816125	E069	-40543
chr11	3816400	3816450	E069	-40218
chr11	3844485	3845151	E069	-11517
chr11	3845226	3845424	E069	-11244
chr11	3845867	3846970	E069	-9698
chr11	3847011	3847081	E069	-9587
chr11	3847099	3847373	E069	-9295
chr11	3847603	3847675	E069	-8993
chr11	3849119	3849163	E069	-7505
chr11	3849179	3849413	E069	-7255
chr11	3849471	3849617	E069	-7051
chr11	3849676	3849721	E069	-6947
chr11	3849727	3849781	E069	-6887
chr11	3851782	3851838	E069	-4830
chr11	3851957	3852003	E069	-4665
chr11	3852047	3852237	E069	-4431
chr11	3852295	3852353	E069	-4315
chr11	3852548	3852588	E069	-4080
chr11	3852655	3852778	E069	-3890
chr11	3852788	3852877	E069	-3791
chr11	3852936	3853245	E069	-3423
chr11	3853281	3853478	E069	-3190
chr11	3853504	3853886	E069	-2782
chr11	3853939	3854003	E069	-2665
chr11	3854045	3854095	E069	-2573
chr11	3854112	3854271	E069	-2397
chr11	3854626	3854666	E069	-2002
chr11	3854779	3854931	E069	-1737
chr11	3854983	3855068	E069	-1600
chr11	3855183	3855243	E069	-1425
chr11	3855601	3856883	E069	0
chr11	3856896	3857327	E069	228
chr11	3857609	3857849	E069	941
chr11	3857995	3858045	E069	1327
chr11	3858177	3858982	E069	1509
chr11	3859482	3859585	E069	2814
chr11	3879598	3879814	E069	22930
chr11	3879864	3880133	E069	23196
chr11	3880144	3880528	E069	23476
chr11	3886549	3886692	E069	29881
chr11	3886702	3886770	E069	30034
chr11	3886861	3887784	E069	30193
chr11	3898540	3899370	E069	41872
chr11	3901958	3902296	E069	45290
chr11	3879598	3879814	E070	22930
chr11	3879864	3880133	E070	23196
chr11	3880144	3880528	E070	23476
chr11	3881181	3881307	E070	24513
chr11	3898540	3899370	E070	41872
chr11	3807152	3807248	E071	-49420
chr11	3807334	3807479	E071	-49189
chr11	3807483	3807563	E071	-49105
chr11	3807661	3807701	E071	-48967
chr11	3807894	3808458	E071	-48210
chr11	3808629	3808754	E071	-47914
chr11	3844485	3845151	E071	-11517
chr11	3845226	3845424	E071	-11244
chr11	3845432	3845609	E071	-11059
chr11	3845731	3845860	E071	-10808
chr11	3845867	3846970	E071	-9698
chr11	3847011	3847081	E071	-9587
chr11	3847099	3847373	E071	-9295
chr11	3847603	3847675	E071	-8993
chr11	3849119	3849163	E071	-7505
chr11	3849179	3849413	E071	-7255
chr11	3849471	3849617	E071	-7051
chr11	3849676	3849721	E071	-6947
chr11	3849727	3849781	E071	-6887
chr11	3850275	3850420	E071	-6248
chr11	3850456	3850504	E071	-6164
chr11	3850755	3850810	E071	-5858
chr11	3850826	3850928	E071	-5740
chr11	3851319	3851374	E071	-5294
chr11	3851565	3851634	E071	-5034
chr11	3852047	3852237	E071	-4431
chr11	3852295	3852353	E071	-4315
chr11	3852548	3852588	E071	-4080
chr11	3852655	3852778	E071	-3890
chr11	3852788	3852877	E071	-3791
chr11	3852936	3853245	E071	-3423
chr11	3853281	3853478	E071	-3190
chr11	3853504	3853886	E071	-2782
chr11	3853939	3854003	E071	-2665
chr11	3854045	3854095	E071	-2573
chr11	3854112	3854271	E071	-2397
chr11	3854626	3854666	E071	-2002
chr11	3854779	3854931	E071	-1737
chr11	3854983	3855068	E071	-1600
chr11	3855183	3855243	E071	-1425
chr11	3857609	3857849	E071	941
chr11	3857995	3858045	E071	1327
chr11	3858177	3858982	E071	1509
chr11	3879598	3879814	E071	22930
chr11	3879864	3880133	E071	23196
chr11	3880144	3880528	E071	23476
chr11	3886861	3887784	E071	30193
chr11	3888450	3889525	E071	31782
chr11	3898540	3899370	E071	41872
chr11	3901214	3901710	E071	44546
chr11	3901958	3902296	E071	45290
chr11	3807894	3808458	E072	-48210
chr11	3844485	3845151	E072	-11517
chr11	3845226	3845424	E072	-11244
chr11	3845432	3845609	E072	-11059
chr11	3845731	3845860	E072	-10808
chr11	3845867	3846970	E072	-9698
chr11	3847011	3847081	E072	-9587
chr11	3847099	3847373	E072	-9295
chr11	3848598	3848687	E072	-7981
chr11	3848709	3848835	E072	-7833
chr11	3848866	3848916	E072	-7752
chr11	3848980	3849030	E072	-7638
chr11	3849119	3849163	E072	-7505
chr11	3849179	3849413	E072	-7255
chr11	3849471	3849617	E072	-7051
chr11	3849676	3849721	E072	-6947
chr11	3849727	3849781	E072	-6887
chr11	3850275	3850420	E072	-6248
chr11	3850456	3850504	E072	-6164
chr11	3850755	3850810	E072	-5858
chr11	3852936	3853245	E072	-3423
chr11	3853281	3853478	E072	-3190
chr11	3853504	3853886	E072	-2782
chr11	3853939	3854003	E072	-2665
chr11	3854045	3854095	E072	-2573
chr11	3854112	3854271	E072	-2397
chr11	3854626	3854666	E072	-2002
chr11	3854779	3854931	E072	-1737
chr11	3854983	3855068	E072	-1600
chr11	3855183	3855243	E072	-1425
chr11	3855601	3856883	E072	0
chr11	3857609	3857849	E072	941
chr11	3857995	3858045	E072	1327
chr11	3858177	3858982	E072	1509
chr11	3858984	3859431	E072	2316
chr11	3859482	3859585	E072	2814
chr11	3880144	3880528	E072	23476
chr11	3888450	3889525	E072	31782
chr11	3898540	3899370	E072	41872
chr11	3901958	3902296	E072	45290
chr11	3831474	3831533	E073	-25135
chr11	3845867	3846970	E073	-9698
chr11	3848598	3848687	E073	-7981
chr11	3848709	3848835	E073	-7833
chr11	3848866	3848916	E073	-7752
chr11	3848980	3849030	E073	-7638
chr11	3849119	3849163	E073	-7505
chr11	3849179	3849413	E073	-7255
chr11	3853504	3853886	E073	-2782
chr11	3853939	3854003	E073	-2665
chr11	3854045	3854095	E073	-2573
chr11	3854112	3854271	E073	-2397
chr11	3854626	3854666	E073	-2002
chr11	3854779	3854931	E073	-1737
chr11	3854983	3855068	E073	-1600
chr11	3855183	3855243	E073	-1425
chr11	3855601	3856883	E073	0
chr11	3856896	3857327	E073	228
chr11	3857609	3857849	E073	941
chr11	3857995	3858045	E073	1327
chr11	3858177	3858982	E073	1509
chr11	3858984	3859431	E073	2316
chr11	3859482	3859585	E073	2814
chr11	3879598	3879814	E073	22930
chr11	3879864	3880133	E073	23196
chr11	3880144	3880528	E073	23476
chr11	3881181	3881307	E073	24513
chr11	3886381	3886432	E073	29713
chr11	3886549	3886692	E073	29881
chr11	3886702	3886770	E073	30034
chr11	3886861	3887784	E073	30193
chr11	3901214	3901710	E073	44546
chr11	3806785	3807013	E074	-49655
chr11	3807152	3807248	E074	-49420
chr11	3807334	3807479	E074	-49189
chr11	3807483	3807563	E074	-49105
chr11	3807894	3808458	E074	-48210
chr11	3844485	3845151	E074	-11517
chr11	3845226	3845424	E074	-11244
chr11	3845432	3845609	E074	-11059
chr11	3845867	3846970	E074	-9698
chr11	3847011	3847081	E074	-9587
chr11	3847099	3847373	E074	-9295
chr11	3847603	3847675	E074	-8993
chr11	3847736	3848546	E074	-8122
chr11	3848598	3848687	E074	-7981
chr11	3848709	3848835	E074	-7833
chr11	3849119	3849163	E074	-7505
chr11	3849179	3849413	E074	-7255
chr11	3849471	3849617	E074	-7051
chr11	3849676	3849721	E074	-6947
chr11	3849727	3849781	E074	-6887
chr11	3850275	3850420	E074	-6248
chr11	3850456	3850504	E074	-6164
chr11	3850755	3850810	E074	-5858
chr11	3850826	3850928	E074	-5740
chr11	3851319	3851374	E074	-5294
chr11	3851565	3851634	E074	-5034
chr11	3851782	3851838	E074	-4830
chr11	3851957	3852003	E074	-4665
chr11	3852047	3852237	E074	-4431
chr11	3852295	3852353	E074	-4315
chr11	3852548	3852588	E074	-4080
chr11	3852655	3852778	E074	-3890
chr11	3852788	3852877	E074	-3791
chr11	3852936	3853245	E074	-3423
chr11	3853281	3853478	E074	-3190
chr11	3853504	3853886	E074	-2782
chr11	3853939	3854003	E074	-2665
chr11	3854045	3854095	E074	-2573
chr11	3854112	3854271	E074	-2397
chr11	3854626	3854666	E074	-2002
chr11	3854779	3854931	E074	-1737
chr11	3854983	3855068	E074	-1600
chr11	3855183	3855243	E074	-1425
chr11	3857609	3857849	E074	941
chr11	3857995	3858045	E074	1327
chr11	3858177	3858982	E074	1509
chr11	3859482	3859585	E074	2814
chr11	3879598	3879814	E074	22930
chr11	3879864	3880133	E074	23196
chr11	3880144	3880528	E074	23476
chr11	3881181	3881307	E074	24513
chr11	3888450	3889525	E074	31782
chr11	3819951	3820047	E081	-36621
chr11	3820115	3820208	E081	-36460
chr11	3816045	3816125	E082	-40543
chr11	3816400	3816450	E082	-40218

Promoter Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance(-/+:Up/Downstream)
chr11	3817385	3819636	E067	-37032
chr11	3828853	3831193	E067	-25475
chr11	3859600	3863645	E067	2932
chr11	3875148	3878335	E067	18480
chr11	3817385	3819636	E068	-37032
chr11	3828853	3831193	E068	-25475
chr11	3859600	3863645	E068	2932
chr11	3875148	3878335	E068	18480
chr11	3817385	3819636	E069	-37032
chr11	3828853	3831193	E069	-25475
chr11	3859600	3863645	E069	2932
chr11	3875148	3878335	E069	18480
chr11	3817385	3819636	E070	-37032
chr11	3828853	3831193	E070	-25475
chr11	3859600	3863645	E070	2932
chr11	3875148	3878335	E070	18480
chr11	3817385	3819636	E071	-37032
chr11	3828853	3831193	E071	-25475
chr11	3859600	3863645	E071	2932
chr11	3875148	3878335	E071	18480
chr11	3817385	3819636	E072	-37032
chr11	3875148	3878335	E072	18480
chr11	3817385	3819636	E073	-37032
chr11	3828853	3831193	E073	-25475
chr11	3859600	3863645	E073	2932
chr11	3875148	3878335	E073	18480
chr11	3817385	3819636	E074	-37032
chr11	3828853	3831193	E074	-25475
chr11	3859600	3863645	E074	2932
chr11	3875148	3878335	E074	18480
chr11	3817385	3819636	E081	-37032
chr11	3859600	3863645	E081	2932
chr11	3817385	3819636	E082	-37032
chr11	3828853	3831193	E082	-25475
chr11	3859600	3863645	E082	2932
chr11	3875148	3878335	E082	18480