rs1457805

Homo sapiens
C>A
LOC107986324 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C==0045 (1374/29982,GnomAD)
C==0061 (1800/29118,TOPMED)
C==0066 (332/5008,1000G)
C==0022 (83/3854,ALSPAC)
C==0025 (92/3708,TWINSUK)
chr4:159828111 (GRCh38.p7) (4q32.1)
AD
GWASdb2
1   publication(s)
See rs on genome
9 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.159828111C>A
GRCh37.p13 chr 4NC_000004.11:g.160749263C>A

Gene: LOC107986324, uncharacterized LOC107986324(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC107986324 transcript variant X1XR_001741911.1:n.N/AIntron Variant
LOC107986324 transcript variant X2XR_001741912.1:n.N/AGenic Downstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.125A=0.875
1000GenomesAmericanSub694C=0.030A=0.970
1000GenomesEast AsianSub1008C=0.088A=0.912
1000GenomesEuropeSub1006C=0.028A=0.972
1000GenomesGlobalStudy-wide5008C=0.066A=0.934
1000GenomesSouth AsianSub978C=0.030A=0.970
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.022A=0.978
The Genome Aggregation DatabaseAfricanSub8726C=0.101A=0.899
The Genome Aggregation DatabaseAmericanSub838C=0.020A=0.980
The Genome Aggregation DatabaseEast AsianSub1610C=0.089A=0.911
The Genome Aggregation DatabaseEuropeSub18506C=0.017A=0.982
The Genome Aggregation DatabaseGlobalStudy-wide29982C=0.045A=0.954
The Genome Aggregation DatabaseOtherSub302C=0.050A=0.950
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.061A=0.938
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.025A=0.975
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs14578050.000715alcohol dependence20201924

eQTL of rs1457805 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1457805 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr4160758396160758460E0689133
chr4160758396160758460E0719133
chr4160758396160758460E0749133
chr4160759356160759529E07410093
chr4160715730160716170E081-33093
chr4160717407160717559E081-31704
chr4160717588160717714E081-31549
chr4160717407160717559E082-31704
chr4160717588160717714E082-31549