rs1465040

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
T==0245 (7340/29870,GnomAD)
T==0242 (7069/29118,TOPMED)
T==0242 (1211/5008,1000G)
T==0282 (1085/3854,ALSPAC)
T==0290 (1074/3708,TWINSUK)
chr4:122007101 (GRCh38.p7) (4q27)
OD
GWASdb2
1   publication(s)
See rs on genome
2 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.122007101T>C
GRCh37.p13 chr 4NC_000004.11:g.122928256T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.145C=0.855
1000GenomesAmericanSub694T=0.180C=0.820
1000GenomesEast AsianSub1008T=0.346C=0.654
1000GenomesEuropeSub1006T=0.272C=0.728
1000GenomesGlobalStudy-wide5008T=0.242C=0.758
1000GenomesSouth AsianSub978T=0.280C=0.720
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.282C=0.718
The Genome Aggregation DatabaseAfricanSub8700T=0.187C=0.813
The Genome Aggregation DatabaseAmericanSub836T=0.170C=0.830
The Genome Aggregation DatabaseEast AsianSub1586T=0.312C=0.688
The Genome Aggregation DatabaseEuropeSub18446T=0.269C=0.730
The Genome Aggregation DatabaseGlobalStudy-wide29870T=0.245C=0.754
The Genome Aggregation DatabaseOtherSub302T=0.340C=0.660
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.242C=0.757
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.290C=0.710
PMID Title Author Journal
23183491Genome-wide association study identifies a potent locus associated with human opioid sensitivity.Nishizawa DMol Psychiatry

P-Value

SNP ID p-value Traits Study
rs14650401.27E-06Opioid sensitivity23183491

eQTL of rs1465040 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1465040 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr4122901834122902128E071-26128
chr4122901834122902128E074-26128