SNP Detail Info-rs1491377

Organism: Homo sapiens

Alleles: A>G

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

G=0382 (11427/29908,GnomAD)
G=0392 (11429/29118,TOPMED)
G=0428 (2145/5008,1000G)
G=0368 (1419/3854,ALSPAC)
G=0379 (1405/3708,TWINSUK)

Position: chr4:23700935 (GRCh38.p7) (4p15.2)

Phenotype: ND

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 11 Enhancers around

Promoter: 0 Promoter around

Sequence Name	Change(s)
GRCh38.p7 chr 4	NC_000004.12:g.23700935A>G
GRCh37.p13 chr 4	NC_000004.11:g.23702558A>G

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	A=0.573	G=0.427
1000Genomes	American	Sub	694	A=0.660	G=0.340
1000Genomes	East Asian	Sub	1008	A=0.550	G=0.450
1000Genomes	Europe	Sub	1006	A=0.601	G=0.399
1000Genomes	Global	Study-wide	5008	A=0.572	G=0.428
1000Genomes	South Asian	Sub	978	A=0.500	G=0.500
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	A=0.632	G=0.368
The Genome Aggregation Database	African	Sub	8698	A=0.567	G=0.433
The Genome Aggregation Database	American	Sub	838	A=0.700	G=0.300
The Genome Aggregation Database	East Asian	Sub	1606	A=0.596	G=0.404
The Genome Aggregation Database	Europe	Sub	18464	A=0.639	G=0.360
The Genome Aggregation Database	Global	Study-wide	29908	A=0.617	G=0.382
The Genome Aggregation Database	Other	Sub	302	A=0.670	G=0.330
Trans-Omics for Precision Medicine	Global	Study-wide	29118	A=0.607	G=0.392
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	A=0.621	G=0.379

PMID	Title	Author	Journal
17158188	Novel genes identified in a high-density genome wide association study for nicotine dependence.	Bierut LJ	Hum Mol Genet

SNP ID	p-value	Traits	Study
rs1491377	0.000182	nicotine dependence	17158188

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr4	23748891	23749326	E067	46333
chr4	23748367	23748540	E069	45809
chr4	23748891	23749326	E069	46333
chr4	23748891	23749326	E071	46333
chr4	23748367	23748540	E074	45809
chr4	23748891	23749326	E074	46333
chr4	23748891	23749326	E081	46333
chr4	23749594	23750055	E081	47036
chr4	23750163	23750222	E081	47605
chr4	23748367	23748540	E082	45809
chr4	23748891	23749326	E082	46333

rs1491377