rs1499764

Homo sapiens
T>C
TRPC7 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T==0324 (9695/29922,GnomAD)
T==0278 (8100/29118,TOPMED)
T==0314 (1571/5008,1000G)
T==0365 (1406/3854,ALSPAC)
T==0359 (1333/3708,TWINSUK)
chr5:136328500 (GRCh38.p7) (5q31.1)
ND
GWASdb2
1   publication(s)
See rs on genome
1 Enhancer around
3 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 5NC_000005.10:g.136328500T>C
GRCh37.p13 chr 5NC_000005.9:g.135664188T>C

Gene: TRPC7, transient receptor potential cation channel subfamily C member 7(minus strand)

Molecule type Change Amino acid[Codon] SO Term
TRPC7 transcript variant 3NM_001167576.1:c.N/AIntron Variant
TRPC7 transcript variant 2NM_001167577.1:c.N/AIntron Variant
TRPC7 transcript variant 1NM_020389.2:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.216C=0.784
1000GenomesAmericanSub694T=0.220C=0.780
1000GenomesEast AsianSub1008T=0.272C=0.728
1000GenomesEuropeSub1006T=0.343C=0.657
1000GenomesGlobalStudy-wide5008T=0.314C=0.686
1000GenomesSouth AsianSub978T=0.520C=0.480
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.365C=0.635
The Genome Aggregation DatabaseAfricanSub8710T=0.232C=0.768
The Genome Aggregation DatabaseAmericanSub834T=0.260C=0.740
The Genome Aggregation DatabaseEast AsianSub1614T=0.268C=0.732
The Genome Aggregation DatabaseEuropeSub18462T=0.376C=0.623
The Genome Aggregation DatabaseGlobalStudy-wide29922T=0.324C=0.676
The Genome Aggregation DatabaseOtherSub302T=0.250C=0.750
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.278C=0.721
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.359C=0.641
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs14997640.000175nicotine dependence17158188

eQTL of rs1499764 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1499764 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr5135643688135644372E081-19816

Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr5135700942135701290E06836754
chr5135700942135701290E07336754
chr5135700942135701290E08236754