rs1505846

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0353 (10590/29944,GnomAD)
T=0293 (8535/29118,TOPMED)
T=0269 (1349/5008,1000G)
T=0430 (1658/3854,ALSPAC)
T=0438 (1624/3708,TWINSUK)
chr2:139020712 (GRCh38.p7) (2q22.1)
AD
GWASdb2
3   publication(s)
See rs on genome
0 Enhancer around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 2NC_000002.12:g.139020712C>T
GRCh37.p13 chr 2NC_000002.11:g.139778282C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.901T=0.099
1000GenomesAmericanSub694C=0.620T=0.380
1000GenomesEast AsianSub1008C=0.708T=0.292
1000GenomesEuropeSub1006C=0.603T=0.397
1000GenomesGlobalStudy-wide5008C=0.731T=0.269
1000GenomesSouth AsianSub978C=0.730T=0.270
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.570T=0.430
The Genome Aggregation DatabaseAfricanSub8722C=0.857T=0.143
The Genome Aggregation DatabaseAmericanSub836C=0.610T=0.390
The Genome Aggregation DatabaseEast AsianSub1612C=0.744T=0.256
The Genome Aggregation DatabaseEuropeSub18472C=0.540T=0.459
The Genome Aggregation DatabaseGlobalStudy-wide29944C=0.646T=0.353
The Genome Aggregation DatabaseOtherSub302C=0.570T=0.430
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.706T=0.293
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.562T=0.438
PMID Title Author Journal
21703634A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.Wang KSJ Psychiatr Res
20202923A genome-wide association study of alcohol dependence.Bierut LJProc Natl Acad Sci U S A
21956439Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q.Zuo LNeuropsychopharmacology

P-Value

SNP ID p-value Traits Study
rs15058460.00000939alcohol dependence21703634
rs15058460.0002alcohol dependence21956439

eQTL of rs1505846 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1505846 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.