rs1525892

Homo sapiens
G>A
TF : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0309 (9254/29910,GnomAD)
A=0305 (8907/29118,TOPMED)
A=0360 (1805/5008,1000G)
A=0333 (1284/3854,ALSPAC)
A=0335 (1242/3708,TWINSUK)
chr3:133765868 (GRCh38.p7) (3q22.1)
AD
GWASdb2
5   publication(s)
See rs on genome
67 Enhancers around
51 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.133765868G>A
GRCh37.p13 chr 3NC_000003.11:g.133484712G>A
TF RefSeqGeneNG_013080.1:g.24736G>A

Gene: TF, transferrin(plus strand)

Molecule type Change Amino acid[Codon] SO Term
TF transcript variant 1NM_001063.3:c.N/AIntron Variant
TF transcript variant X1XM_017007089.1:c.N/AIntron Variant
TF transcript variant X2XM_017007090.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.738A=0.262
1000GenomesAmericanSub694G=0.600A=0.400
1000GenomesEast AsianSub1008G=0.573A=0.427
1000GenomesEuropeSub1006G=0.652A=0.348
1000GenomesGlobalStudy-wide5008G=0.640A=0.360
1000GenomesSouth AsianSub978G=0.590A=0.410
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.667A=0.333
The Genome Aggregation DatabaseAfricanSub8708G=0.761A=0.239
The Genome Aggregation DatabaseAmericanSub838G=0.540A=0.460
The Genome Aggregation DatabaseEast AsianSub1616G=0.599A=0.401
The Genome Aggregation DatabaseEuropeSub18448G=0.671A=0.328
The Genome Aggregation DatabaseGlobalStudy-wide29910G=0.690A=0.309
The Genome Aggregation DatabaseOtherSub300G=0.750A=0.250
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.694A=0.305
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.665A=0.335
PMID Title Author Journal
21665994Genome-wide association study identifies two loci strongly affecting transferrin glycosylation.Kutalik ZHum Mol Genet
22761678Associations between single nucleotide polymorphisms in iron-related genes and iron status in multiethnic populations.McLaren CEPLoS One
23386860Exploring genome-wide - dietary heme iron intake interactions and the risk of type 2 diabetes.Pasquale LRFront Genet
27332551Associations between Common Variants in Iron-Related Genes with Haematological Traits in Populations of African Ancestry.Gichohi-Wainaina WNPLoS One
21483845Genome-wide association study identifies genetic loci associated with iron deficiency.McLaren CEPLoS One

P-Value

SNP ID p-value Traits Study
rs15258922.05E-13alcohol consumption21665994

eQTL of rs1525892 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1525892 in Fetal Brain

Probe ID Position Gene beta p-value
cg16414030chr3:133502952-0.1108991933413193.6917e-37
cg01448562chr3:133502909-0.0703522297899756.1128e-35
cg08048268chr3:133502702-0.1586090079907912.7334e-34
cg16275903chr3:133524006SRPRB0.06522249981324293.9039e-26
cg11941060chr3:133502564-0.07734362670626881.6658e-24
cg20276088chr3:133502917-0.04140932211115681.2545e-23
cg08439880chr3:133502540-0.08256063289830021.8353e-23

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr3133436424133436504E067-48208
chr3133461397133461916E067-22796
chr3133461945133462055E067-22657
chr3133464069133464119E067-20593
chr3133464448133464526E067-20186
chr3133482923133483028E067-1684
chr3133483054133483594E067-1118
chr3133483998133484070E067-642
chr3133436424133436504E068-48208
chr3133464069133464119E068-20593
chr3133482562133482616E068-2096
chr3133482923133483028E068-1684
chr3133483054133483594E068-1118
chr3133436424133436504E069-48208
chr3133461397133461916E069-22796
chr3133461945133462055E069-22657
chr3133464069133464119E069-20593
chr3133473014133473073E069-11639
chr3133473315133473659E069-11053
chr3133476260133476458E069-8254
chr3133482562133482616E069-2096
chr3133482923133483028E069-1684
chr3133483054133483594E069-1118
chr3133483998133484070E069-642
chr3133484337133484387E069-325
chr3133482923133483028E070-1684
chr3133483054133483594E070-1118
chr3133436424133436504E071-48208
chr3133461397133461916E071-22796
chr3133461945133462055E071-22657
chr3133464069133464119E071-20593
chr3133473014133473073E071-11639
chr3133473315133473659E071-11053
chr3133482562133482616E071-2096
chr3133482923133483028E071-1684
chr3133483054133483594E071-1118
chr3133483998133484070E071-642
chr3133484337133484387E071-325
chr3133461397133461916E072-22796
chr3133461945133462055E072-22657
chr3133464069133464119E072-20593
chr3133464448133464526E072-20186
chr3133473014133473073E072-11639
chr3133482923133483028E072-1684
chr3133483054133483594E072-1118
chr3133483998133484070E072-642
chr3133484337133484387E072-325
chr3133436424133436504E073-48208
chr3133461397133461916E073-22796
chr3133461945133462055E073-22657
chr3133464448133464526E073-20186
chr3133482923133483028E073-1684
chr3133483054133483594E073-1118
chr3133436424133436504E074-48208
chr3133461397133461916E074-22796
chr3133461945133462055E074-22657
chr3133464069133464119E074-20593
chr3133473014133473073E074-11639
chr3133473315133473659E074-11053
chr3133476260133476458E074-8254
chr3133482562133482616E074-2096
chr3133482923133483028E074-1684
chr3133483054133483594E074-1118
chr3133483998133484070E074-642
chr3133484337133484387E074-325
chr3133526132133526214E08141420
chr3133464448133464526E082-20186










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr3133464975133465152E067-19560
chr3133465195133465439E067-19273
chr3133465691133465761E067-18951
chr3133468272133468322E067-16390
chr3133524082133525550E06739370
chr3133525588133525634E06740876
chr3133464975133465152E068-19560
chr3133465195133465439E068-19273
chr3133465691133465761E068-18951
chr3133468272133468322E068-16390
chr3133524082133525550E06839370
chr3133525588133525634E06840876
chr3133464975133465152E069-19560
chr3133465195133465439E069-19273
chr3133465691133465761E069-18951
chr3133468272133468322E069-16390
chr3133524082133525550E06939370
chr3133465195133465439E070-19273
chr3133524082133525550E07039370
chr3133525588133525634E07040876
chr3133464975133465152E071-19560
chr3133465195133465439E071-19273
chr3133465691133465761E071-18951
chr3133468272133468322E071-16390
chr3133524082133525550E07139370
chr3133525588133525634E07140876
chr3133464975133465152E072-19560
chr3133465195133465439E072-19273
chr3133465691133465761E072-18951
chr3133468272133468322E072-16390
chr3133524082133525550E07239370
chr3133525588133525634E07240876
chr3133464975133465152E073-19560
chr3133465195133465439E073-19273
chr3133465691133465761E073-18951
chr3133468272133468322E073-16390
chr3133524082133525550E07339370
chr3133525588133525634E07340876
chr3133464975133465152E074-19560
chr3133465195133465439E074-19273
chr3133465691133465761E074-18951
chr3133468272133468322E074-16390
chr3133524082133525550E07439370
chr3133525588133525634E07440876
chr3133464975133465152E081-19560
chr3133524082133525550E08139370
chr3133525588133525634E08140876
chr3133464975133465152E082-19560
chr3133465195133465439E082-19273
chr3133524082133525550E08239370
chr3133525588133525634E08240876