rs1532010

Homo sapiens
G>A / G>T
OSBPL1A : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0149 (4467/29912,GnomAD)
T=0149 (4354/29118,TOPMED)
T=0177 (884/5008,1000G)
T=0100 (385/3854,ALSPAC)
T=0093 (344/3708,TWINSUK)
chr18:24348077 (GRCh38.p7) (18q11.2)
ND
GWASdb2
1   publication(s)
See rs on genome
348 Enhancers around
13 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 18NC_000018.10:g.24348077G>A
GRCh38.p7 chr 18NC_000018.10:g.24348077G>T
GRCh37.p13 chr 18NC_000018.9:g.21928041G>A
GRCh37.p13 chr 18NC_000018.9:g.21928041G>T
OSBPL1A RefSeqGeneNG_029432.1:g.54793C>T
OSBPL1A RefSeqGeneNG_029432.1:g.54793C>A

Gene: OSBPL1A, oxysterol binding protein like 1A(minus strand)

Molecule type Change Amino acid[Codon] SO Term
OSBPL1A transcript variant 2NM_080597.3:c.N/AIntron Variant
OSBPL1A transcript variant 3NM_001242508.1:c.N/AGenic Upstream Transcript Variant
OSBPL1A transcript variant 1NM_018030.4:c.N/AGenic Upstream Transcript Variant
OSBPL1A transcript variant X2XM_006722380.3:c.N/AIntron Variant
OSBPL1A transcript variant X4XM_006722382.3:c.N/AIntron Variant
OSBPL1A transcript variant X1XM_017025530.1:c.N/AIntron Variant
OSBPL1A transcript variant X3XM_017025531.1:c.N/AIntron Variant
OSBPL1A transcript variant X7XM_017025532.1:c.N/AIntron Variant
OSBPL1A transcript variant X8XM_017025533.1:c.N/AGenic Upstream Transcript Variant
OSBPL1A transcript variant X9XM_017025534.1:c.N/AGenic Upstream Transcript Variant
OSBPL1A transcript variant X5XR_001753139.1:n.N/AIntron Variant
OSBPL1A transcript variant X6XR_001753140.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.750T=0.250
1000GenomesAmericanSub694G=0.930T=0.070
1000GenomesEast AsianSub1008G=0.741T=0.259
1000GenomesEuropeSub1006G=0.904T=0.096
1000GenomesGlobalStudy-wide5008G=0.823T=0.177
1000GenomesSouth AsianSub978G=0.850T=0.150
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.900T=0.100
The Genome Aggregation DatabaseAfricanSub8702G=0.795A=0.000
The Genome Aggregation DatabaseAmericanSub832G=0.920A=0.00,
The Genome Aggregation DatabaseEast AsianSub1608G=0.791A=0.000
The Genome Aggregation DatabaseEuropeSub18470G=0.877A=0.000
The Genome Aggregation DatabaseGlobalStudy-wide29912G=0.850A=0.000
The Genome Aggregation DatabaseOtherSub300G=0.910A=0.00,
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.850T=0.149
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.907T=0.093
PMID Title Author Journal
17407593Molecular genetics of nicotine dependence and abstinence: whole genome association using 520,000 SNPs.Uhl GRBMC Genet

P-Value

SNP ID p-value Traits Study
rs15320100.0007nicotine dependence17407593

eQTL of rs1532010 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1532010 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr185580789355808092E067-45436
chr185580811155808243E067-45285
chr185580839655808475E067-45053
chr185584425355844954E067-8574
chr185584571255846321E067-7207
chr185585569855855780E0672170
chr185585588855855962E0672360
chr185585610155856666E0672573
chr185588327055884040E06729742
chr185588412255884184E06730594
chr185588436455884612E06730836
chr185589064155892035E06737113
chr185580755555807634E068-45894
chr185580767255807766E068-45762
chr185580789355808092E068-45436
chr185580811155808243E068-45285
chr185580839655808475E068-45053
chr185581439755814480E068-39048
chr185581464755814697E068-38831
chr185581492955814979E068-38549
chr185581509555815200E068-38328
chr185581573655815786E068-37742
chr185581604555816095E068-37433
chr185581623655816382E068-37146
chr185581638955816695E068-36833
chr185581679655816940E068-36588
chr185583060655830859E068-22669
chr185583087355830953E068-22575
chr185583688755836937E068-16591
chr185585502955855243E0681501
chr185585527955855329E0681751
chr185585548955855529E0681961
chr185585569855855780E0682170
chr185585588855855962E0682360
chr185585610155856666E0682573
chr185585668455856803E0683156
chr185586097855861062E0687450
chr185586903755869309E06815509
chr185586931155869996E06815783
chr185587485255874975E06821324
chr185587512155875199E06821593
chr185587527955875483E06821751
chr185587550555876147E06821977
chr185588055755882093E06827029
chr185589064155892035E06837113
chr185589237955892679E06838851
chr185589270855893002E06839180
chr185589578155896000E06842253
chr185589606255896327E06842534
chr185580744455807519E069-46009
chr185580755555807634E069-45894
chr185580767255807766E069-45762
chr185580789355808092E069-45436
chr185580811155808243E069-45285
chr185580839655808475E069-45053
chr185583627255836748E069-16780
chr185583688755836937E069-16591
chr185583694155837029E069-16499
chr185584425355844954E069-8574
chr185584719455847244E069-6284
chr185584725755847307E069-6221
chr185584733055847370E069-6158
chr185584744355847806E069-5722
chr185586111655863143E0697588
chr185587527955875483E06921751
chr185587550555876147E06921977
chr185580425655804619E070-48909
chr185580463555804685E070-48843
chr185580471855804768E070-48760
chr185580479855804935E070-48593
chr185580497355805052E070-48476
chr185580559555805645E070-47883
chr185580568755805817E070-47711
chr185580590255805971E070-47557
chr185580605955806271E070-47257
chr185580683655807183E070-46345
chr185580721155807265E070-46263
chr185580744455807519E070-46009
chr185580755555807634E070-45894
chr185580767255807766E070-45762
chr185580789355808092E070-45436
chr185580811155808243E070-45285
chr185580839655808475E070-45053
chr185580855755808710E070-44818
chr185581199155812369E070-41159
chr185581396455814004E070-39524
chr185581439755814480E070-39048
chr185581464755814697E070-38831
chr185581492955814979E070-38549
chr185581509555815200E070-38328
chr185581573655815786E070-37742
chr185582332755823411E070-30117
chr185582379855823838E070-29690
chr185582389055823933E070-29595
chr185583579255835865E070-17663
chr185583627255836748E070-16780
chr185583954055839580E070-13948
chr185584222655842984E070-10544
chr185584307155843471E070-10057
chr185584356855843618E070-9910
chr185584382555844120E070-9408
chr185584425355844954E070-8574
chr185584509455845521E070-8007
chr185584571255846321E070-7207
chr185584640155846581E070-6947
chr185584667155846721E070-6807
chr185584674655846922E070-6606
chr185584694155846991E070-6537
chr185584719455847244E070-6284
chr185584725755847307E070-6221
chr185584733055847370E070-6158
chr185584744355847806E070-5722
chr185584906555849197E070-4331
chr185584920255849256E070-4272
chr185584936155849487E070-4041
chr185584967255849740E070-3788
chr185584974655849800E070-3728
chr185585026955850945E070-2583
chr185585151355851553E070-1975
chr185585217655852512E070-1016
chr185585255355852662E070-866
chr185585322255854678E0700
chr185585502955855243E0701501
chr185585527955855329E0701751
chr185585548955855529E0701961
chr185585569855855780E0702170
chr185585588855855962E0702360
chr185585610155856666E0702573
chr185585668455856803E0703156
chr185586097855861062E0707450
chr185586111655863143E0707588
chr185586664355866752E07013115
chr185586686555867112E07013337
chr185586711355867228E07013585
chr185586931155869996E07015783
chr185587218355872276E07018655
chr185587232955872373E07018801
chr185587243155873175E07018903
chr185587527955875483E07021751
chr185587550555876147E07021977
chr185588055755882093E07027029
chr185588234655882640E07028818
chr185588283255882891E07029304
chr185588327055884040E07029742
chr185588412255884184E07030594
chr185588436455884612E07030836
chr185588772055888279E07034192
chr185588838455889080E07034856
chr185589270855893002E07039180
chr185589314855893228E07039620
chr185589350955894041E07039981
chr185589419955894266E07040671
chr185589441755894474E07040889
chr185589480955894998E07041281
chr185589537255895770E07041844
chr185589578155896000E07042253
chr185589606255896327E07042534
chr185589639855896526E07042870
chr185589653355896609E07043005
chr185589662655896684E07043098
chr185580755555807634E071-45894
chr185580767255807766E071-45762
chr185580789355808092E071-45436
chr185580811155808243E071-45285
chr185580839655808475E071-45053
chr185580855755808710E071-44818
chr185583627255836748E071-16780
chr185583688755836937E071-16591
chr185583694155837029E071-16499
chr185586903755869309E07115509
chr185586931155869996E07115783
chr185589064155892035E07137113
chr185580789355808092E072-45436
chr185580811155808243E072-45285
chr185580839655808475E072-45053
chr185581019655810274E072-43254
chr185581034055811193E072-42335
chr185581573655815786E072-37742
chr185581604555816095E072-37433
chr185581623655816382E072-37146
chr185581638955816695E072-36833
chr185581679655816940E072-36588
chr185583579255835865E072-17663
chr185583627255836748E072-16780
chr185584425355844954E072-8574
chr185587527955875483E07221751
chr185587550555876147E07221977
chr185588055755882093E07227029
chr185589064155892035E07237113
chr185580789355808092E073-45436
chr185580811155808243E073-45285
chr185580839655808475E073-45053
chr185581019655810274E073-43254
chr185581034055811193E073-42335
chr185581509555815200E073-38328
chr185581573655815786E073-37742
chr185583694155837029E073-16499
chr185586903755869309E07315509
chr185586931155869996E07315783
chr185587512155875199E07321593
chr185587527955875483E07321751
chr185587550555876147E07321977
chr185580388955803985E074-49543
chr185580683655807183E074-46345
chr185580721155807265E074-46263
chr185580744455807519E074-46009
chr185580755555807634E074-45894
chr185580767255807766E074-45762
chr185580789355808092E074-45436
chr185580811155808243E074-45285
chr185580839655808475E074-45053
chr185580855755808710E074-44818
chr185580874955808803E074-44725
chr185580884255808923E074-44605
chr185580903755809211E074-44317
chr185581464755814697E074-38831
chr185581492955814979E074-38549
chr185581509555815200E074-38328
chr185581573655815786E074-37742
chr185581604555816095E074-37433
chr185583579255835865E074-17663
chr185583688755836937E074-16591
chr185583874755838953E074-14575
chr185583907755839142E074-14386
chr185586111655863143E0747588
chr185586903755869309E07415509
chr185586931155869996E07415783
chr185589064155892035E07437113
chr185580559555805645E081-47883
chr185580568755805817E081-47711
chr185580590255805971E081-47557
chr185580605955806271E081-47257
chr185580683655807183E081-46345
chr185580721155807265E081-46263
chr185580744455807519E081-46009
chr185580755555807634E081-45894
chr185580767255807766E081-45762
chr185580789355808092E081-45436
chr185580811155808243E081-45285
chr185580839655808475E081-45053
chr185580855755808710E081-44818
chr185580874955808803E081-44725
chr185580884255808923E081-44605
chr185580903755809211E081-44317
chr185581011355810157E081-43371
chr185581019655810274E081-43254
chr185581199155812369E081-41159
chr185581396455814004E081-39524
chr185581439755814480E081-39048
chr185581464755814697E081-38831
chr185581638955816695E081-36833
chr185581679655816940E081-36588
chr185584157255841770E081-11758
chr185584189155841931E081-11597
chr185584222655842984E081-10544
chr185584307155843471E081-10057
chr185584356855843618E081-9910
chr185584382555844120E081-9408
chr185584425355844954E081-8574
chr185584509455845521E081-8007
chr185584571255846321E081-7207
chr185584640155846581E081-6947
chr185584667155846721E081-6807
chr185584674655846922E081-6606
chr185584694155846991E081-6537
chr185585322255854678E0810
chr185585527955855329E0811751
chr185585548955855529E0811961
chr185585569855855780E0812170
chr185585588855855962E0812360
chr185586061755860694E0817089
chr185586082855860884E0817300
chr185586097855861062E0817450
chr185586111655863143E0817588
chr185587001155870199E08116483
chr185587020655870311E08116678
chr185587039455870445E08116866
chr185587071355871080E08117185
chr185587218355872276E08118655
chr185587232955872373E08118801
chr185587243155873175E08118903
chr185588055755882093E08127029
chr185588234655882640E08128818
chr185588537655885791E08131848
chr185588582555885940E08132297
chr185588598855886060E08132460
chr185589350955894041E08139981
chr185589419955894266E08140671
chr185589537255895770E08141844
chr185589578155896000E08142253
chr185589606255896327E08142534
chr185589639855896526E08142870
chr185589653355896609E08143005
chr185589662655896684E08143098
chr185590200455902923E08148476
chr185580463555804685E082-48843
chr185580471855804768E082-48760
chr185580479855804935E082-48593
chr185580497355805052E082-48476
chr185580683655807183E082-46345
chr185580721155807265E082-46263
chr185580744455807519E082-46009
chr185580755555807634E082-45894
chr185580767255807766E082-45762
chr185580789355808092E082-45436
chr185580811155808243E082-45285
chr185580839655808475E082-45053
chr185580855755808710E082-44818
chr185580874955808803E082-44725
chr185580884255808923E082-44605
chr185581019655810274E082-43254
chr185581396455814004E082-39524
chr185581439755814480E082-39048
chr185581464755814697E082-38831
chr185582332755823411E082-30117
chr185583047555830587E082-22941
chr185584189155841931E082-11597
chr185584222655842984E082-10544
chr185584382555844120E082-9408
chr185584425355844954E082-8574
chr185584509455845521E082-8007
chr185584571255846321E082-7207
chr185585322255854678E0820
chr185586111655863143E0827588
chr185586411755865277E08210589
chr185586931155869996E08215783
chr185587218355872276E08218655
chr185587399855874047E08220470
chr185587408255874142E08220554
chr185587457955874658E08221051
chr185588234655882640E08228818
chr185588283255882891E08229304
chr185588327055884040E08229742
chr185588412255884184E08230594
chr185588436455884612E08230836
chr185588838455889080E08234856
chr185589350955894041E08239981
chr185589419955894266E08240671
chr185589441755894474E08240889
chr185589480955894998E08241281
chr185589537255895770E08241844
chr185589578155896000E08242253
chr185589606255896327E08242534
chr185589639855896526E08242870
chr185589653355896609E08243005
chr185590176155901814E08248233
chr185590186255901983E08248334
chr185590200455902923E08248476










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr185586321455863885E0679686
chr185586400355864108E06710475
chr185586321455863885E0689686
chr185586400355864108E06810475
chr185588917555889587E06835647
chr185586321455863885E0699686
chr185586321455863885E0709686
chr185586400355864108E07010475
chr185586321455863885E0719686
chr185586321455863885E0729686
chr185586400355864108E07210475
chr185586321455863885E0739686
chr185586400355864108E07310475