rs1561105

Homo sapiens
T>G
LOC107986930 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G=0233 (6988/29926,GnomAD)
G=0257 (7484/29118,TOPMED)
G=0239 (1195/5008,1000G)
G=0240 (926/3854,ALSPAC)
G=0234 (869/3708,TWINSUK)
chr8:23753286 (GRCh38.p7) (8p21.2)
AD
GWASdb2
1   publication(s)
See rs on genome
2 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.23753286T>G
GRCh37.p13 chr 8NC_000008.10:g.23610799T>G

Gene: LOC107986930, uncharacterized LOC107986930(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC107986930 transcript variant X3XR_001745842.1:n.N/AIntron Variant
LOC107986930 transcript variant X1XR_001745840.1:n.N/AGenic Downstream Transcript Variant
LOC107986930 transcript variant X2XR_001745841.1:n.N/AGenic Downstream Transcript Variant
LOC107986930 transcript variant X4XR_001745843.1:n.N/AGenic Downstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.713G=0.287
1000GenomesAmericanSub694T=0.780G=0.220
1000GenomesEast AsianSub1008T=0.889G=0.111
1000GenomesEuropeSub1006T=0.742G=0.258
1000GenomesGlobalStudy-wide5008T=0.761G=0.239
1000GenomesSouth AsianSub978T=0.700G=0.300
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.760G=0.240
The Genome Aggregation DatabaseAfricanSub8710T=0.730G=0.270
The Genome Aggregation DatabaseAmericanSub836T=0.820G=0.180
The Genome Aggregation DatabaseEast AsianSub1616T=0.881G=0.119
The Genome Aggregation DatabaseEuropeSub18462T=0.771G=0.228
The Genome Aggregation DatabaseGlobalStudy-wide29926T=0.766G=0.233
The Genome Aggregation DatabaseOtherSub302T=0.730G=0.270
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.743G=0.257
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.766G=0.234
PMID Title Author Journal
24277619ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.Quillen EEAm J Med Genet B Neuropsychiatr Genet

P-Value

SNP ID p-value Traits Study
rs15611050.00094alcohol consumption (maxi-drinks)24277619

eQTL of rs1561105 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1561105 in Fetal Brain

Probe ID Position Gene beta p-value
cg21590108chr8:236090570.07171133984256121.0021e-18

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr82361855223618602E0717753
chr82359547823595577E081-15222