rs1586681

Homo sapiens
G>C / G>T
LOC105376118 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
G==0146 (4390/29930,GnomAD)
G==0160 (4682/29118,TOPMED)
G==0135 (678/5008,1000G)
G==0150 (579/3854,ALSPAC)
G==0137 (507/3708,TWINSUK)
chr9:85032519 (GRCh38.p7) (9q21.33)
AD
GWASdb2
1   publication(s)
See rs on genome
0 Enhancer around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 9NC_000009.12:g.85032519G>C
GRCh38.p7 chr 9NC_000009.12:g.85032519G>T
GRCh37.p13 chr 9NC_000009.11:g.87647434G>C
GRCh37.p13 chr 9NC_000009.11:g.87647434G>T

Gene: LOC105376118, uncharacterized LOC105376118(minus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105376118 transcript variant X3XR_001746806.1:n.N/AIntron Variant
LOC105376118 transcript variant X1XR_930048.2:n.N/AIntron Variant
LOC105376118 transcript variant X2XR_930049.2:n.N/AIntron Variant
LOC105376118 transcript variant X4XR_930050.2:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.168T=0.832
1000GenomesAmericanSub694G=0.070T=0.930
1000GenomesEast AsianSub1008G=0.054T=0.946
1000GenomesEuropeSub1006G=0.143T=0.857
1000GenomesGlobalStudy-wide5008G=0.135T=0.865
1000GenomesSouth AsianSub978G=0.210T=0.790
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.150T=0.850
The Genome Aggregation DatabaseAfricanSub8718G=0.178T=0.822
The Genome Aggregation DatabaseAmericanSub836G=0.070T=0.930
The Genome Aggregation DatabaseEast AsianSub1616G=0.036T=0.964
The Genome Aggregation DatabaseEuropeSub18458G=0.143T=0.856
The Genome Aggregation DatabaseGlobalStudy-wide29930G=0.146T=0.853
The Genome Aggregation DatabaseOtherSub302G=0.230T=0.770
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.160T=0.839
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.137T=0.863
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs15866810.000378alcohol dependence21314694

eQTL of rs1586681 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1586681 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.