rs1612945

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
C==0230 (6885/29924,GnomAD)
C==0213 (6218/29118,TOPMED)
C==0216 (1082/5008,1000G)
C==0279 (1076/3854,ALSPAC)
C==0277 (1026/3708,TWINSUK)
chr14:41266738 (GRCh38.p7) (14q21.1)
ND
GWASdb2
1   publication(s)
See rs on genome
3 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 14NC_000014.9:g.41266738C>T
GRCh37.p13 chr 14NC_000014.8:g.41735941C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.112T=0.888
1000GenomesAmericanSub694C=0.210T=0.790
1000GenomesEast AsianSub1008C=0.202T=0.798
1000GenomesEuropeSub1006C=0.261T=0.739
1000GenomesGlobalStudy-wide5008C=0.216T=0.784
1000GenomesSouth AsianSub978C=0.330T=0.670
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.279T=0.721
The Genome Aggregation DatabaseAfricanSub8716C=0.169T=0.831
The Genome Aggregation DatabaseAmericanSub836C=0.170T=0.830
The Genome Aggregation DatabaseEast AsianSub1602C=0.204T=0.796
The Genome Aggregation DatabaseEuropeSub18468C=0.263T=0.736
The Genome Aggregation DatabaseGlobalStudy-wide29924C=0.230T=0.769
The Genome Aggregation DatabaseOtherSub302C=0.240T=0.760
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.213T=0.786
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.277T=0.723
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs16129458.91E-05nicotine dependence17158188

eQTL of rs1612945 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1612945 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr144175450541754720E07018564
chr144174720041747372E08111259
chr144174720041747372E08211259