rs1662051

Homo sapiens
C>A
ADH1C : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0333 (9961/29856,GnomAD)
A=0261 (7618/29118,TOPMED)
A=0214 (1074/5008,1000G)
A=0398 (1535/3854,ALSPAC)
A=0410 (1522/3708,TWINSUK)
chr4:99346082 (GRCh38.p7) (4q23)
AD
GWASCatalog
1   publication(s)
See rs on genome
6 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.99346082C>A
GRCh37.p13 chr 4NC_000004.11:g.100267239C>A
ADH1C RefSeqGeneNG_011718.1:g.11679G>T

Gene: ADH1C, alcohol dehydrogenase 1C (class I), gamma polypeptide(minus strand)

Molecule type Change Amino acid[Codon] SO Term
ADH1C transcript variant 1NM_000669.4:c.N/AIntron Variant
ADH1C transcript variant 2NR_133005.1:n.N/AIntron Variant
ADH1C transcript variant X1XM_011531588.2:c.N/AIntron Variant
ADH1C transcript variant X2XM_011531589.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.900A=0.100
1000GenomesAmericanSub694C=0.730A=0.270
1000GenomesEast AsianSub1008C=0.924A=0.076
1000GenomesEuropeSub1006C=0.595A=0.405
1000GenomesGlobalStudy-wide5008C=0.786A=0.214
1000GenomesSouth AsianSub978C=0.720A=0.280
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.602A=0.398
The Genome Aggregation DatabaseAfricanSub8702C=0.854A=0.146
The Genome Aggregation DatabaseAmericanSub832C=0.680A=0.320
The Genome Aggregation DatabaseEast AsianSub1622C=0.913A=0.087
The Genome Aggregation DatabaseEuropeSub18400C=0.553A=0.446
The Genome Aggregation DatabaseGlobalStudy-wide29856C=0.666A=0.333
The Genome Aggregation DatabaseOtherSub300C=0.750A=0.250
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.738A=0.261
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.590A=0.410
PMID Title Author Journal
24166409Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.Gelernter JMol Psychiatry

P-Value

SNP ID p-value Traits Study
rs16620512E-06alcohol dependence24166409

eQTL of rs1662051 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs1662051 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr4100245602100245886E068-21353
chr4100221669100221897E070-45342
chr4100244954100245162E073-22077
chr4100245344100245493E073-21746
chr4100221669100221897E082-45342
chr4100222048100222444E082-44795