rs16827526

Homo sapiens
T>G
None
Check p-value
SNV (Single Nucleotide Variation)
G=0159 (4785/29950,GnomAD)
G=0129 (3772/29118,TOPMED)
G=0130 (652/5008,1000G)
G=0171 (658/3854,ALSPAC)
G=0170 (630/3708,TWINSUK)
chr2:186176102 (GRCh38.p7) (2q32.1)
AD
GWASdb2
1   publication(s)
See rs on genome
13 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 2NC_000002.12:g.186176102T>G
GRCh37.p13 chr 2NC_000002.11:g.187040829T>G

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.887G=0.113
1000GenomesAmericanSub694T=0.880G=0.120
1000GenomesEast AsianSub1008T=0.898G=0.102
1000GenomesEuropeSub1006T=0.847G=0.153
1000GenomesGlobalStudy-wide5008T=0.870G=0.130
1000GenomesSouth AsianSub978T=0.830G=0.170
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.829G=0.171
The Genome Aggregation DatabaseAfricanSub8716T=0.879G=0.121
The Genome Aggregation DatabaseAmericanSub838T=0.920G=0.080
The Genome Aggregation DatabaseEast AsianSub1618T=0.904G=0.096
The Genome Aggregation DatabaseEuropeSub18476T=0.812G=0.187
The Genome Aggregation DatabaseGlobalStudy-wide29950T=0.840G=0.159
The Genome Aggregation DatabaseOtherSub302T=0.820G=0.180
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.870G=0.129
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.830G=0.170
PMID Title Author Journal
22072270Genome-wide association study identifies 5q21 and 9p24.1 (KDM4C) loci associated with alcohol withdrawal symptoms.Wang KSJ Neural Transm (Vienna)

P-Value

SNP ID p-value Traits Study
rs168275264.3E-05alcohol withdrawal symptoms22072270

eQTL of rs16827526 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr2:187040829RP11-410E4.1ENSG00000259915.1T>G2.2822e-6-180671Frontal_Cortex_BA9
Chr2:187040829RP11-410E4.1ENSG00000259915.1T>G1.2644e-5-180671Cortex
Chr2:187040829RP11-410E4.1ENSG00000259915.1T>G9.1565e-8-180671Caudate_basal_ganglia
Chr2:187040829RP11-410E4.1ENSG00000259915.1T>G1.8646e-10-180671Putamen_basal_ganglia

meQTL of rs16827526 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr2186995406186996137E068-44692
chr2186995406186996137E070-44692
chr2187053033187053666E07212204
chr2187070151187070720E07229322
chr2187070151187070720E07429322
chr2186991046186991159E081-49670
chr2186995406186996137E081-44692
chr2186996181186996288E081-44541
chr2186996293186996361E081-44468
chr2186990877186990927E082-49902
chr2186990934186990997E082-49832
chr2186991046186991159E082-49670
chr2187070151187070720E08229322