rs16854429

Homo sapiens
G>C / G>T
TDRD5 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
T=0213 (25885/121324,ExAC)
T=0179 (5378/29944,GnomAD)
T=0151 (4402/29118,TOPMED)
G==0168 (2192/13006,GO-ESP)
T=0220 (1103/5008,1000G)
T=0212 (816/3854,ALSPAC)
T=0220 (814/3708,TWINSUK)
chr1:179640454 (GRCh38.p7) (1q25.2)
AD
GWASdb2
1   publication(s)
See rs on genome
7 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 1NC_000001.11:g.179640454G>C
GRCh38.p7 chr 1NC_000001.11:g.179640454G>T
GRCh37.p13 chr 1NC_000001.10:g.179609589G>C
GRCh37.p13 chr 1NC_000001.10:g.179609589G>T

Gene: TDRD5, tudor domain containing 5(plus strand)

Molecule type Change Amino acid[Codon] SO Term
TDRD5 transcript variant 1NM_001199085.1:c.N/AIntron Variant
TDRD5 transcript variant 2NM_001199089.1:c.N/AIntron Variant
TDRD5 transcript variant 4NM_001199091.1:c.N/AIntron Variant
TDRD5 transcript variant 5NM_001199092.1:c.N/AIntron Variant
TDRD5 transcript variant 3NM_173533.3:c.N/AIntron Variant
TDRD5 transcript variant X1XM_005244934.1:c.N/AIntron Variant
TDRD5 transcript variant X2XM_005244935.4:c.N/AIntron Variant
TDRD5 transcript variant X3XM_017000473.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.918T=0.082
1000GenomesAmericanSub694G=0.750T=0.250
1000GenomesEast AsianSub1008G=0.645T=0.355
1000GenomesEuropeSub1006G=0.788T=0.212
1000GenomesGlobalStudy-wide5008G=0.780T=0.220
1000GenomesSouth AsianSub978G=0.750T=0.250
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.788T=0.212
The Exome Aggregation ConsortiumAmericanSub21968G=0.824T=0.176
The Exome Aggregation ConsortiumAsianSub25140G=0.705T=0.294
The Exome Aggregation ConsortiumEuropeSub73310G=0.803T=0.197
The Exome Aggregation ConsortiumGlobalStudy-wide121324G=0.786T=0.213
The Exome Aggregation ConsortiumOtherSub906G=0.810T=0.190
The Genome Aggregation DatabaseAfricanSub8720G=0.910T=0.090
The Genome Aggregation DatabaseAmericanSub838G=0.770T=0.230
The Genome Aggregation DatabaseEast AsianSub1616G=0.639T=0.361
The Genome Aggregation DatabaseEuropeSub18468G=0.796T=0.203
The Genome Aggregation DatabaseGlobalStudy-wide29944G=0.820T=0.179
The Genome Aggregation DatabaseOtherSub302G=0.810T=0.190
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.848T=0.151
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.780T=0.220
PMID Title Author Journal
21703634A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.Wang KSJ Psychiatr Res

P-Value

SNP ID p-value Traits Study
rs168544297.29E-05alcohol dependence21703634

eQTL of rs16854429 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs16854429 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr17293971272939862E0813887
chr17294108772941542E0815262
chr17294160872941689E0815783
chr17294178272941896E0815957
chr17294108772941542E0825262
chr17294160872941689E0825783
chr17294178272941896E0825957