rs16860281

Homo sapiens
T>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0108 (3240/29962,GnomAD)
C=0132 (3871/29118,TOPMED)
C=0095 (474/5008,1000G)
C=0088 (341/3854,ALSPAC)
C=0091 (339/3708,TWINSUK)
chr3:148277560 (GRCh38.p7) (3q24)
ND
GWASdb2
1   publication(s)
See rs on genome
7 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 3NC_000003.12:g.148277560T>C
GRCh37.p13 chr 3NC_000003.11:g.147995347T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.757C=0.243
1000GenomesAmericanSub694T=0.940C=0.060
1000GenomesEast AsianSub1008T=0.999C=0.001
1000GenomesEuropeSub1006T=0.921C=0.079
1000GenomesGlobalStudy-wide5008T=0.905C=0.095
1000GenomesSouth AsianSub978T=0.970C=0.030
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.912C=0.088
The Genome Aggregation DatabaseAfricanSub8718T=0.799C=0.201
The Genome Aggregation DatabaseAmericanSub838T=0.930C=0.070
The Genome Aggregation DatabaseEast AsianSub1620T=0.999C=0.001
The Genome Aggregation DatabaseEuropeSub18484T=0.923C=0.076
The Genome Aggregation DatabaseGlobalStudy-wide29962T=0.891C=0.108
The Genome Aggregation DatabaseOtherSub302T=0.930C=0.070
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.867C=0.132
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.909C=0.091
PMID Title Author Journal
19268276Genome-wide association study of smoking initiation and current smoking.Vink JMAm J Hum Genet

P-Value

SNP ID p-value Traits Study
rs168602817.34E-06nicotine smoking19268276

eQTL of rs16860281 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs16860281 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr3147987063147988743E069-6604
chr3147987063147988743E071-6604
chr3147987063147988743E072-6604
chr3147947105147947165E074-48182
chr3147983419147983655E074-11692
chr3147983693147983967E074-11380
chr3147987063147988743E074-6604