rs16922195

Organism: Homo sapiens

Alleles: A>G

Gene : Feature

None

p-value: Check p-value

Variation Type: SNV (Single Nucleotide Variation)

Frequency:

G=0182 (5431/29830,GnomAD)
G=0179 (5216/29118,TOPMED)
G=0188 (941/5008,1000G)
G=0173 (667/3854,ALSPAC)
G=0182 (675/3708,TWINSUK)

Position: chr11:95559293 (GRCh38.p7) (11q21)

Phenotype: ND

Dataset:

GWASdb2

Publications: 1 publication(s)

Genomic View: See rs on genome

Enhancer: 81 Enhancers around

Promoter: 0 Promoter around

Variant Details Frequency Publications p-values eSNP meSNP

Genomic Coordinates

Sequence Name	Change(s)
GRCh38.p7 chr 11	NC_000011.10:g.95559293A>G
GRCh37.p13 chr 11	NC_000011.9:g.95292457A>G

Study	Population	Group	Sample #	Ref Allele	Alt Allele
1000Genomes	African	Sub	1322	A=0.840	G=0.160
1000Genomes	American	Sub	694	A=0.610	G=0.390
1000Genomes	East Asian	Sub	1008	A=0.833	G=0.167
1000Genomes	Europe	Sub	1006	A=0.828	G=0.172
1000Genomes	Global	Study-wide	5008	A=0.812	G=0.188
1000Genomes	South Asian	Sub	978	A=0.880	G=0.120
The Avon Longitudinal Study of Parents and Children	PARENT AND CHILD COHORT	Study-wide	3854	A=0.827	G=0.173
The Genome Aggregation Database	African	Sub	8686	A=0.851	G=0.149
The Genome Aggregation Database	American	Sub	836	A=0.610	G=0.390
The Genome Aggregation Database	East Asian	Sub	1592	A=0.786	G=0.214
The Genome Aggregation Database	Europe	Sub	18414	A=0.813	G=0.186
The Genome Aggregation Database	Global	Study-wide	29830	A=0.817	G=0.182
The Genome Aggregation Database	Other	Sub	302	A=0.870	G=0.130
Trans-Omics for Precision Medicine	Global	Study-wide	29118	A=0.820	G=0.179
UK 10K study - Twins	TWIN COHORT	Study-wide	3708	A=0.818	G=0.182

PMID	Title	Author	Journal
17158188	Novel genes identified in a high-density genome wide association study for nicotine dependence.	Bierut LJ	Hum Mol Genet

SNP ID	p-value	Traits	Study
rs16922195	0.000381	nicotine dependence	17158188

Position (v37)	eGene	GeneID	Variant	p-value	TSS	Tissue
There is no eQTL annotation for this SNP

Probe ID	Position	Gene	beta	p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome	Start	End	Region	Distance ( -/+ : Up/Downstream )
chr11	95303746	95304096	E067	11289
chr11	95304191	95304231	E067	11734
chr11	95304328	95304396	E067	11871
chr11	95305159	95305210	E067	12702
chr11	95309174	95310091	E067	16717
chr11	95310138	95310212	E067	17681
chr11	95341147	95341259	E067	48690
chr11	95341343	95341628	E067	48886
chr11	95257698	95258226	E068	-34231
chr11	95289254	95290498	E068	-1959
chr11	95290519	95290667	E068	-1790
chr11	95297026	95297411	E068	4569
chr11	95297422	95297548	E068	4965
chr11	95297669	95297853	E068	5212
chr11	95298827	95299312	E068	6370
chr11	95299389	95299798	E068	6932
chr11	95303035	95303085	E068	10578
chr11	95303746	95304096	E068	11289
chr11	95305159	95305210	E068	12702
chr11	95305233	95305273	E068	12776
chr11	95297026	95297411	E069	4569
chr11	95297422	95297548	E069	4965
chr11	95297669	95297853	E069	5212
chr11	95298827	95299312	E069	6370
chr11	95299389	95299798	E069	6932
chr11	95303746	95304096	E069	11289
chr11	95304191	95304231	E069	11734
chr11	95304328	95304396	E069	11871
chr11	95325471	95326093	E069	33014
chr11	95326174	95326284	E069	33717
chr11	95340093	95340170	E069	47636
chr11	95341147	95341259	E069	48690
chr11	95341343	95341628	E069	48886
chr11	95298827	95299312	E070	6370
chr11	95299389	95299798	E070	6932
chr11	95289254	95290498	E071	-1959
chr11	95297026	95297411	E071	4569
chr11	95297422	95297548	E071	4965
chr11	95297669	95297853	E071	5212
chr11	95298827	95299312	E071	6370
chr11	95299389	95299798	E071	6932
chr11	95304191	95304231	E071	11734
chr11	95304328	95304396	E071	11871
chr11	95305159	95305210	E071	12702
chr11	95305233	95305273	E071	12776
chr11	95309174	95310091	E071	16717
chr11	95319513	95319857	E071	27056
chr11	95341147	95341259	E071	48690
chr11	95341343	95341628	E071	48886
chr11	95287091	95287816	E072	-4641
chr11	95289254	95290498	E072	-1959
chr11	95297422	95297548	E072	4965
chr11	95298827	95299312	E072	6370
chr11	95299389	95299798	E072	6932
chr11	95303746	95304096	E072	11289
chr11	95304191	95304231	E072	11734
chr11	95304328	95304396	E072	11871
chr11	95305159	95305210	E072	12702
chr11	95305233	95305273	E072	12776
chr11	95323685	95323791	E072	31228
chr11	95325471	95326093	E072	33014
chr11	95326174	95326284	E072	33717
chr11	95341343	95341628	E072	48886
chr11	95289254	95290498	E073	-1959
chr11	95310138	95310212	E073	17681
chr11	95325471	95326093	E073	33014
chr11	95305159	95305210	E074	12702
chr11	95309174	95310091	E074	16717
chr11	95310138	95310212	E074	17681
chr11	95319168	95319473	E074	26711
chr11	95319513	95319857	E074	27056
chr11	95341147	95341259	E074	48690
chr11	95341343	95341628	E074	48886
chr11	95289254	95290498	E081	-1959
chr11	95290519	95290667	E081	-1790
chr11	95290686	95290795	E081	-1662
chr11	95298827	95299312	E081	6370
chr11	95299389	95299798	E081	6932
chr11	95304191	95304231	E081	11734
chr11	95304328	95304396	E081	11871
chr11	95289254	95290498	E082	-1959

rs16922195

Genomic Coordinates

Population Frequency

P-Value

eQTL of rs16922195 in Brain tissues (GTEx Analysis Release V7)

meQTL of rs16922195 in Fetal Brain

Genomic View

Chromatin Interaction

Enhancer Annotation (GRCh37.p13)