20656943 | Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease. | Pillai SG | Am J Respir Crit Care Med |
19132693 | Variants in nicotinic acetylcholine receptors alpha5 and alpha3 increase risks to nicotine dependence. | Chen X | Am J Med Genet B Neuropsychiatr Genet |
21750227 | Single-nucleotide polymorphisms (5p15.33, 15q25.1, 6p22.1, 6q27 and 7p15.3) and lung cancer survival in the European Prospective Investigation into Cancer and Nutrition (EPIC). | Xun WW | Mutagenesis |
19010884 | Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine. | Le Marchand L | Cancer Res |
18227835 | Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking. | Berrettini W | Mol Psychiatry |
26771213 | Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease. | Hobbs BD | Am J Respir Crit Care Med |
20624154 | Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes. | Grucza RA | Addict Biol |
19789337 | Haplotype and cell proliferation analyses of candidate lung cancer susceptibility genes on chromosome 15q24-25.1. | Liu Y | Cancer Res |
22719919 | Glutamate and synaptic plasticity systems and smoking behavior: results from a genetic association study. | dos Santos VA | PLoS One |
24686516 | CHRNA3 polymorphism modifies lung adenocarcinoma risk in the Chinese Han population. | He P | Int J Mol Sci |
22223462 | Alpha-5 and -3 nicotinic receptor gene variants predict nicotine dependence but not cessation: findings from the COMMIT cohort. | Bousman CA | Am J Med Genet B Neuropsychiatr Genet |
19944766 | A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia. | Meda SA | Neuroimage |
24084939 | A common biological basis of obesity and nicotine addiction. | Thorgeirsson TE | Transl Psychiatry |
19492010 | The genetic components of alcohol and nicotine co-addiction: from genes to behavior. | Schlaepfer IR | Curr Drug Abuse Rev |
23689675 | Genetic risk for nicotine dependence in the cholinergic system and activation of the brain reward system in healthy adolescents. | Nees F | Neuropsychopharmacology |
21748402 | A twin association study of nicotine dependence with markers in the CHRNA3 and CHRNA5 genes. | Maes HH | Behav Genet |
18165968 | Identification of pharmacogenetic markers in smoking cessation therapy. | Heitjan DF | Am J Med Genet B Neuropsychiatr Genet |
22046326 | 'Smoking genes': a genetic association study. | Verde Z | PLoS One |
18414406 | Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence. | Wang JC | Mol Psychiatry |
25826680 | Genetic risks to nicotine dependence predict negative mood and affect in current non-smokers. | Chen X | Sci Rep |
19443489 | Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. | Wang JC | Hum Mol Genet |
23196875 | Variants in the 15q25 gene cluster are associated with risk for schizophrenia and bipolar disorder. | Jackson KJ | Psychiatr Genet |
19482438 | Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence. | Etter JF | Addict Behav |
18957677 | The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer. | Spitz MR | J Natl Cancer Inst |
20808433 | Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population. | Li MD | PLoS One |
23143843 | Molecular mechanisms underlying behaviors related to nicotine addiction. | Picciotto MR | Cold Spring Harb Perspect Med |
26942719 | Chromosome 15q25 (CHRNA3-CHRNB4) Variation Indirectly Impacts Lung Cancer Risk in Chinese Males. | Zhang Y | PLoS One |
21440309 | Association of FKBP5, COMT and CHRNA5 polymorphisms with PTSD among outpatients at risk for PTSD. | Boscarino JA | Psychiatry Res |
22534784 | Association between genetic variants on chromosome 15q25 locus and objective measures of tobacco exposure. | Munafo MR | J Natl Cancer Inst |
19238175 | New insights into the genetics of addiction. | Li MD | Nat Rev Genet |
28069549 | SNPs within CHRNA5-A3-B4 and CYP2A6/B6 are associated with smoking dependence but not with tobacco dependence treatment outcomes in the Czech population. | Hubacek JA | Gene |
23942779 | A genome-wide association study of behavioral disinhibition. | McGue M | Behav Genet |
20643934 | A genetically modulated, intrinsic cingulate circuit supports human nicotine addiction. | Hong LE | Proc Natl Acad Sci U S A |
20886544 | Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance. | Winterer G | Am J Med Genet B Neuropsychiatr Genet |
19596527 | Nicotine dependence and genetic variation in the nicotinic receptors. | Bierut LJ | Drug Alcohol Depend |
17135278 | Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. | Saccone SF | Hum Mol Genet |
22665477 | Function of human alpha3beta4alpha5 nicotinic acetylcholine receptors is reduced by the alpha5(D398N) variant. | George AA | J Biol Chem |
24065931 | The CHRNA3 rs578776 Variant is Associated with an Intrinsic Reward Sensitivity Deficit in Smokers. | Robinson JD | Front Psychiatry |
19760673 | Association of CHRN genes with "dizziness" to tobacco. | Ehringer MA | Am J Med Genet B Neuropsychiatr Genet |
23870182 | Bridging the clinical gaps: genetic, epigenetic and transcriptomic biomarkers for the early detection of lung cancer in the post-National Lung Screening Trial era. | Brothers JF | BMC Med |
25051068 | Four SNPs in the CHRNA3/5 alpha-neuronal nicotinic acetylcholine receptor subunit locus are associated with COPD risk based on meta-analyses. | Cui K | PLoS One |
21697764 | Susceptibility locus for lung cancer at 15q25.1 is not associated with risk of pancreatic cancer. | Chen J | Pancreas |
23397474 | Polymorphisms of CHRNA5-CHRNA3-CHRNB4 Gene Cluster and NSCLC Risk in Chinese Population. | Li Z | Transl Oncol |
27166759 | Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions. | Yang J | Mol Psychiatry |
27335628 | A prospective and retrospective analysis of smoking behavior changes in ever smokers with high risk for lung cancer from New Mexico and Pennsylvania. | Leng S | Int J Mol Epidemiol Genet |
22301922 | Measuring alcohol consumption for genomic meta-analyses of alcohol intake: opportunities and challenges. | Agrawal A | Am J Clin Nutr |
24838476 | Vitamin C supplementation for pregnant smoking women and pulmonary function in their newborn infants: a randomized clinical trial. | McEvoy CT | JAMA |
21418140 | A CHRNA5 allele related to nicotine addiction and schizophrenia. | Hong LE | Genes Brain Behav |
19259974 | Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. | Saccone NL | Am J Med Genet B Neuropsychiatr Genet |
20485328 | Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes. | Sherva R | Neuropsychopharmacology |
26282330 | The role of haplotype in 15q25.1 locus in lung cancer risk: results of scanning chromosome 15. | Ji X | Carcinogenesis |
20631687 | Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 and its interaction with recent tobacco use influence cognitive flexibility. | Zhang H | Neuropsychopharmacology |
21929786 | Significance testing in ridge regression for genetic data. | Cule E | BMC Bioinformatics |
18759969 | In search of causal variants: refining disease association signals using cross-population contrasts. | Saccone NL | BMC Genet |
26351737 | Nicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug use. | Melroy-Greif WE | Genes Brain Behav |
20981002 | Breaking barriers in the genomics and pharmacogenetics of drug addiction. | Ho MK | Clin Pharmacol Ther |
21335511 | A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers. | Chen D | Cancer Epidemiol Biomarkers Prev |
19859904 | Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans. | Li MD | Am J Med Genet B Neuropsychiatr Genet |
21079997 | Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence. | Culverhouse RC | Hum Genet |
18519132 | A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence. | Grucza RA | Biol Psychiatry |
27827986 | Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence. | Zuo L | Genes (Basel) |
24388127 | Mendelian randomization in health research: using appropriate genetic variants and avoiding biased estimates. | Taylor AE | Econ Hum Biol |
19474294 | Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. | Hindorff LA | Proc Natl Acad Sci U S A |
22028403 | A case-control study of a sex-specific association between a 15q25 variant and lung cancer risk. | Wei C | Cancer Epidemiol Biomarkers Prev |
25293386 | Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium. | Taylor AE | BMJ Open |
25302169 | Acetylcholine receptor pathway in lung cancer: New twists to an old story. | Niu XM | World J Clin Oncol |
23942621 | Interaction between polygenic risk for cigarette use and environmental exposures in the Detroit Neighborhood Health Study. | Meyers JL | Transl Psychiatry |
21338875 | Genetic vulnerability and susceptibility to substance dependence. | Bierut LJ | Neuron |
23793356 | Neuroimaging in psychiatric pharmacogenetics research: the promise and pitfalls. | Falcone M | Neuropsychopharmacology |
18783506 | Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking. | Sherva R | Addiction |
22914670 | Association of IREB2 and CHRNA3/5 polymorphisms with COPD and COPD-related phenotypes in a Chinese Han population. | Zhou H | J Hum Genet |
22042774 | Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence. | Haller G | Hum Mol Genet |
19184766 | A testable prognostic model of nicotine dependence. | Ramoni RB | J Neurogenet |
23443019 | Association between a 15q25 gene variant, nicotine-related habits, lung cancer and COPD among 56,307 individuals from the HUNT study in Norway. | Gabrielsen ME | Eur J Hum Genet |
23872218 | Functional characterization of SNPs in CHRNA3/B4 intergenic region associated with drug behaviors. | Flora AV | Brain Res |
24727484 | CHRNA5 variant predicts smoking cessation in patients with acute myocardial infarction. | Chen LS | Nicotine Tob Res |
19436041 | Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes. | Baker TB | Nicotine Tob Res |
20418890 | Genome-wide meta-analyses identify multiple loci associated with smoking behavior. | - | Nat Genet |
25233467 | Role of nicotine dependence on the relationship between variants in the nicotinic receptor genes and risk of lung adenocarcinoma. | Tseng TS | PLoS One |
22832964 | Genome-wide meta-analyses of smoking behaviors in African Americans. | David SP | Transl Psychiatry |
23249876 | Nicotinic acetylcholine receptor variation and response to smoking cessation therapies. | Bergen AW | Pharmacogenet Genomics |
22854838 | The influence of race and ethnicity on the biology of cancer. | Henderson BE | Nat Rev Cancer |
21268243 | Markers in the 15q24 nicotinic receptor subunit gene cluster (CHRNA5-A3-B4) predict severity of nicotine addiction and response to smoking cessation therapy. | Sarginson JE | Am J Med Genet B Neuropsychiatr Genet |
23349703 | Variants in the 15q24/25 locus associate with lung function decline in active smokers. | Mohamed Hoesein FA | PLoS One |
20587604 | Fine mapping of chromosome 15q25.1 lung cancer susceptibility in African-Americans. | Hansen HM | Hum Mol Genet |
19247474 | Genome-wide and candidate gene association study of cigarette smoking behaviors. | Caporaso N | PLoS One |
25642160 | Nicotinic receptor modulation to treat alcohol and drug dependence. | Rahman S | Front Neurosci |
23875064 | Scrutiny of the CHRNA5-CHRNA3-CHRNB4 smoking behavior locus reveals a novel association with alcohol use in a Finnish population based study. | Hallfors J | Int J Mol Epidemiol Genet |
18978134 | Lung cancer gene associated with COPD: triple whammy or possible confounding effect? | Young RP | Eur Respir J |
22281715 | Recent advances in the genetic epidemiology and molecular genetics of substance use disorders. | Kendler KS | Nat Neurosci |
21593077 | Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index. | Freathy RM | Int J Epidemiol |
22438940 | Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking. | Kapoor M | PLoS One |
27134767 | Genome-wide time-to-event analysis on smoking progression stages in a family-based study. | He L | Brain Behav |
20529875 | SPOT: a web-based tool for using biological databases to prioritize SNPs after a genome-wide association study. | Saccone SF | Nucleic Acids Res |
22539395 | Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25. | Chen LS | Genet Epidemiol |
22648373 | Interplay of genetic risk factors (CHRNA5-CHRNA3-CHRNB4) and cessation treatments in smoking cessation success. | Chen LS | Am J Psychiatry |
25874685 | CHRNA3 rs6495308 genotype as an effect modifier of the association between daily cigarette consumption and hypertension in Chinese male smokers. | Wu XY | Int J Environ Res Public Health |
21858091 | In vitro and ex vivo analysis of CHRNA3 and CHRNA5 haplotype expression. | Doyle GA | PLoS One |
22052802 | Gene-environment interactions of novel variants associated with head and neck cancer. | Liang C | Head Neck |
25036316 | Joint association of nicotinic acetylcholine receptor variants with abdominal obesity in American Indians: the Strong Heart Family Study. | Zhu Y | PLoS One |
20159342 | Genetics of addictions. | Hartz SM | Psychiatr Clin North Am |
26961927 | Best (but oft-forgotten) practices: the design, analysis, and interpretation of Mendelian randomization studies. | Haycock PC | Am J Clin Nutr |
21690317 | CHRNA3 rs1051730 genotype and short-term smoking cessation. | Munafo MR | Nicotine Tob Res |
18385676 | Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. | Amos CI | Nat Genet |
22080838 | A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. | Cho MH | Hum Mol Genet |
22176972 | Nicotinic acetylcholine receptor variants associated with susceptibility to chronic obstructive pulmonary disease: a meta-analysis. | Zhang J | Respir Res |
21559498 | Chromosome 15q25 (CHRNA3-CHRNA5) variation impacts indirectly on lung cancer risk. | Wang Y | PLoS One |
23178447 | Lung cancer risk in relation to nicotinic acetylcholine receptor, CYP2A6 and CYP1A1 genotypes in the Bangladeshi population. | Islam MS | Clin Chim Acta |
20056643 | A rigorous and comprehensive validation: common genetic variations and lung cancer. | Yang P | Cancer Epidemiol Biomarkers Prev |
24819610 | DRD2/CHRNA5 interaction on prefrontal biology and physiology during working memory. | Di Giorgio A | PLoS One |
20418889 | Meta-analysis and imputation refines the association of 15q25 with smoking quantity. | Liu JZ | Nat Genet |
21500120 | Lung cancer in never smokers. | Yang P | Semin Respir Crit Care Med |
21168125 | TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood. | Ducci F | Biol Psychiatry |
19390575 | Lung cancer susceptibility model based on age, family history and genetic variants. | Young RP | PLoS One |
26981579 | Gene by Environment Investigation of Incident Lung Cancer Risk in African-Americans. | David SP | EBioMedicine |
20840187 | Peer smoking and the nicotinic receptor genes: an examination of genetic and environmental risks for nicotine dependence. | Johnson EO | Addiction |
26264275 | Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium. | Morris RW | BMJ Open |
26981122 | The Oncogenic Functions of Nicotinic Acetylcholine Receptors. | Zhao Y | J Oncol |
20147892 | Convergent evidence that choline acetyltransferase gene variation is associated with prospective smoking cessation and nicotine dependence. | Ray R | Neuropsychopharmacology |
21810735 | Single nucleotide polymorphisms in CHRNA5 rs16969968, CHRNA3 rs578776, and LOC123688 rs8034191 are associated with heaviness of smoking in women in Northeastern Ontario, Canada. | Conlon MS | Nicotine Tob Res |
22806211 | The genetics of addiction-a translational perspective. | Agrawal A | Transl Psychiatry |
19300482 | A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. | Pillai SG | PLoS Genet |
21955800 | The polymorphism of the CHRNA5 gene and the strength of nicotine addiction in lung cancer and COPD patients. | Wojas-Krawczyk K | Eur J Cancer Prev |
19064933 | Chromosome 15q25.1 genetic markers associated with level of response to alcohol in humans. | Joslyn G | Proc Natl Acad Sci U S A |
19005185 | Contribution of nicotine acetylcholine receptor polymorphisms to lung cancer risk in a smoking-independent manner in the Japanese. | Shiraishi K | Carcinogenesis |
26044620 | Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction. | Reyes-Gibby CC | BMC Syst Biol |
21808284 | Gender-stratified gene and gene-treatment interactions in smoking cessation. | Lee W | Pharmacogenomics J |
24186853 | Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking. | Stephens SH | Genet Epidemiol |
25948103 | A CHRNA5 Smoking Risk Variant Decreases the Aversive Effects of Nicotine in Humans. | Jensen KP | Neuropsychopharmacology |
22102629 | Dissection of the phenotypic and genotypic associations with nicotinic dependence. | Chen LS | Nicotine Tob Res |
18519524 | Variants in nicotinic receptors and risk for nicotine dependence. | Bierut LJ | Am J Psychiatry |
26239294 | Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans. | Olfson E | Mol Psychiatry |
22837378 | Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. | Wilk JB | Am J Respir Crit Care Med |
21808609 | Components of cross-frequency modulation in health and disease. | Allen EA | Front Syst Neurosci |
27758088 | The CHRNA5/CHRNA3/CHRNB4 Nicotinic Receptor Regulome: Genomic Architecture, Regulatory Variants, and Clinical Associations. | Barrie ES | Hum Mutat |
18565990 | Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence. | Saccone SF | Bioinformatics |
26695521 | Mendelian Randomization - the Key to Understanding Aspects of Parkinson's Disease Causation? | Noyce AJ | Mov Disord |
23226157 | Gender differences in cancer susceptibility: an inadequately addressed issue. | Dorak MT | Front Genet |
21304900 | Individual and cumulative effects of GWAS susceptibility loci in lung cancer: associations after sub-phenotyping for COPD. | Young RP | PLoS One |
20395203 | A second genetic variant on chromosome 15q24-25.1 associates with lung cancer. | Liu P | Cancer Res |
24934182 | CHRNA5 variants moderate the effect of nicotine deprivation on a neural index of cognitive control. | Evans DE | Genes Brain Behav |
27327258 | Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research. | Wen L | Transl Psychiatry |
25674902 | Sex matters! Interactions of sex and polymorphisms of a cholinergic receptor gene (CHRNA5) modulate response speed. | Schneider KK | Neuroreport |
25214750 | Genomics and personalized medicine: CHRNA5-CHRNA3-CHRNB4 and smoking cessation treatment. | Chen LS | J Food Drug Anal |
26010901 | Lack of Associations of CHRNA5-A3-B4 Genetic Variants with Smoking Cessation Treatment Outcomes in Caucasian Smokers despite Associations with Baseline Smoking. | Tyndale RF | PLoS One |
22048466 | Smoking cessation pharmacogenetics: analysis of varenicline and bupropion in placebo-controlled clinical trials. | King DP | Neuropsychopharmacology |
18571741 | Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research. | Portugal GS | Behav Brain Res |
24733007 | Association of CHRNA5-A3-B4 SNP rs2036527 with smoking cessation therapy response in African-American smokers. | Zhu AZ | Clin Pharmacol Ther |
21606948 | Varenicline for smoking cessation: nausea severity and variation in nicotinic receptor genes. | Swan GE | Pharmacogenomics J |
22544838 | From men to mice: CHRNA5/CHRNA3, smoking behavior and disease. | Ware JJ | Nicotine Tob Res |
21229299 | Chromosome 15q24-25.1 variants, diet, and lung cancer susceptibility in cigarette smokers. | Sakoda LC | Cancer Causes Control |
22899653 | Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. | Timofeeva MN | Hum Mol Genet |
27694844 | An Adaptive Fisher's Combination Method for Joint Analysis of Multiple Phenotypes in Association Studies. | Liang X | Sci Rep |
21193173 | A common genetic variant in the neurexin superfamily member CNTNAP2 is associated with increased risk for selective mutism and social anxiety-related traits. | Stein MB | Biol Psychiatry |
22438921 | Nicotinic acetylcholine receptor variants are related to smoking habits, but not directly to COPD. | Budulac SE | PLoS One |
23943838 | Effect of neuronal nicotinic acetylcholine receptor genes (CHRN) on longitudinal cigarettes per day in adolescents and young adults. | Cannon DS | Nicotine Tob Res |
23454887 | Role of selected genetic variants in lung cancer risk in African Americans. | Spitz MR | J Thorac Oncol |
19733931 | Blood-based CHRNA3 single nucleotide polymorphism and outcome in advanced non-small-cell lung cancer patients. | Carcereny E | Lung Cancer |
20725741 | Nicotinic acetylcholine receptor genes on chromosome 15q25.1 are associated with nicotine and opioid dependence severity. | Erlich PM | Hum Genet |
20548021 | Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium. | Truong T | J Natl Cancer Inst |
26228411 | Examining gene-environment interactions in comorbid depressive and disruptive behavior disorders using a Bayesian approach. | Adrian M | J Psychiatr Res |
19330903 | Gene by smoking interaction in hypertension: identification of a major quantitative trait locus on chromosome 15q for systolic blood pressure in Mexican-Americans. | Montasser ME | J Hypertens |
20581870 | From smoking to lung cancer: the CHRNA5/A3/B4 connection. | Improgo MR | Oncogene |
19465454 | The TERT-CLPTM1L lung cancer susceptibility variant associates with higher DNA adduct formation in the lung. | Zienolddiny S | Carcinogenesis |
26142345 | Genetic variation (CHRNA5), medication (combination nicotine replacement therapy vs. varenicline), and smoking cessation. | Chen LS | Drug Alcohol Depend |
21430647 | The galanin receptor 1 gene associates with tobacco craving in smokers seeking cessation treatment. | Lori A | Neuropsychopharmacology |
20700436 | Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. | Saccone NL | PLoS Genet |
22640768 | The genetic basis of addictive disorders. | Ducci F | Psychiatr Clin North Am |
27121382 | Incorporating epistasis interaction of genetic susceptibility single nucleotide polymorphisms in a lung cancer risk prediction model. | Marcus MW | Int J Oncol |
24682045 | Identification of CHRNA5 rare variants in African-American heavy smokers. | Doyle GA | Psychiatr Genet |
23221128 | Fine-mapping of the 5p15.33, 6p22.1-p21.31, and 15q25.1 regions identifies functional and histology-specific lung cancer susceptibility loci in African-Americans. | Walsh KM | Cancer Epidemiol Biomarkers Prev |
25658328 | Polymorphism in the serotonin receptor 2a (HTR2A) gene as possible predisposal factor for aggressive traits. | Banlaki Z | PLoS One |
23358500 | Variation in the alpha 5 nicotinic acetylcholine receptor subunit gene predicts cigarette smoking intensity as a function of nicotine content. | Macqueen DA | Pharmacogenomics J |
20736995 | Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerstrom test for nicotine dependence. | Wessel J | Neuropsychopharmacology |
22820273 | Impact of human D398N single nucleotide polymorphism on intracellular calcium response mediated by alpha3beta4alpha5 nicotinic acetylcholine receptors. | Tammimaki A | Neuropharmacology |
21191315 | Genetic association of bipolar disorder with the beta(3) nicotinic receptor subunit gene. | Hartz SM | Psychiatr Genet |
21081471 | Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study. | Gago-Dominguez M | Carcinogenesis |
19776245 | Association between a 15q25 gene variant, smoking quantity and tobacco-related cancers among 17 000 individuals. | Lips EH | Int J Epidemiol |
26671949 | Effect of smoking on physical and cognitive capability in later life: a multicohort study using observational and genetic approaches. | North TL | BMJ Open |
22536069 | Higher FKBP5, COMT, CHRNA5, and CRHR1 allele burdens are associated with PTSD and interact with trauma exposure: implications for neuropsychiatric research and treatment. | Boscarino JA | Neuropsychiatr Dis Treat |
21228559 | An exploratory study on the CHRNA3-CHRNA5-CHRNB4 cluster, smoking, and Parkinson's disease. | Gao J | Neurodegener Dis |
27835950 | Targeted high-throughput sequencing of candidate genes for chronic obstructive pulmonary disease. | Matsson H | BMC Pulm Med |
19706762 | The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. | Saccone NL | Cancer Res |
21862624 | Genetic polymorphisms in 15q25 and 19q13 loci, cotinine levels, and risk of lung cancer in EPIC. | Timofeeva MN | Cancer Epidemiol Biomarkers Prev |
25045619 | The Genetics, Neurogenetics and Pharmacogenetics of Addiction. | Demers CH | Curr Behav Neurosci Rep |
22042234 | Externalizing behaviors are associated with SNPs in the CHRNA5/CHRNA3/CHRNB4 gene cluster. | Stephens SH | Behav Genet |
22008662 | The association of the alpha-5 subunit of the nicotinic acetylcholine receptor gene and the brain-derived neurotrophic factor gene with different aspects of smoking behavior. | Breetvelt EJ | Psychiatr Genet |
24588897 | CHRNA5 and CHRNA3 variants and level of neuroticism in young adult Mexican American men and women. | Criado JR | Twin Res Hum Genet |
23692359 | CHRNA5-A3-B4 genetic variants alter nicotine intake and interact with tobacco use to influence body weight in Alaska Native tobacco users. | Zhu AZ | Addiction |
22170288 | Translational genetic approaches to substance use disorders: bridging the gap between mice and humans. | Palmer AA | Hum Genet |
23844051 | Association of CHRNA5-A3-B4 variation with esophageal squamous cell carcinoma risk and smoking behaviors in a Chinese population. | Wang Y | PLoS One |
25632390 | Association between genetic variants on chromosome 15q25 locus and several nicotine dependence traits in Polish population: a case-control study. | Buczkowski K | Biomed Res Int |
21436384 | Genetic variability of smoking persistence in African Americans. | Hamidovic A | Cancer Prev Res (Phila) |
26220977 | A multiancestry study identifies novel genetic associations with CHRNA5 methylation in human brain and risk of nicotine dependence. | Hancock DB | Hum Mol Genet |
27663783 | A Novel Tobacco Use Phenotype Suggests the 15q25 and 19q13 Loci May be Differentially Associated With Cigarettes per Day and Tobacco-Related Problems. | Richmond-Rakerd LS | Nicotine Tob Res |
21686075 | The Role of Genetics in Nicotine Dependence: Mapping the Pathways from Genome to Syndrome. | Mackillop J | Curr Cardiovasc Risk Rep |
21764527 | Association between CHRNA5 genetic variation at rs16969968 and brain reactivity to smoking images in nicotine dependent women. | Janes AC | Drug Alcohol Depend |
22889990 | Natural and orthogonal interaction framework for modeling gene-environment interactions with application to lung cancer. | Ma J | Hum Hered |
19641473 | Racial differences in the association between SNPs on 15q25.1, smoking behavior, and risk of non-small cell lung cancer. | Schwartz AG | J Thorac Oncol |
21618602 | Detecting genetic interactions for quantitative traits with U-statistics. | Li M | Genet Epidemiol |
20854418 | CHRNB2 promoter region: association with subjective effects to nicotine and gene expression differences. | Hoft NR | Genes Brain Behav |
24055496 | A glimpse into the future - Personalized medicine for smoking cessation. | Bierut LJ | Neuropharmacology |
22071378 | Association of the CHRNA5-A3-B4 gene cluster with heaviness of smoking: a meta-analysis. | Ware JJ | Nicotine Tob Res |
27385416 | Alterations in alpha5* nicotinic acetylcholine receptors result in midbrain- and hippocampus-dependent behavioural and neural impairments. | Besson M | Psychopharmacology (Berl) |
20691427 | Genetic associations of brain structural networks in schizophrenia: a preliminary study. | Jagannathan K | Biol Psychiatry |
22701590 | Strong association between two polymorphisms on 15q25.1 and lung cancer risk: a meta-analysis. | Gu M | PLoS One |
18780872 | Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. | Liu P | J Natl Cancer Inst |
26833182 | Genome-Wide Meta-Analysis of Cotinine Levels in Cigarette Smokers Identifies Locus at 4q13.2. | Ware JJ | Sci Rep |
23691092 | Associations of prenatal nicotine exposure and the dopamine related genes ANKK1 and DRD2 to verbal language. | Eicher JD | PLoS One |
20022891 | The evolving discipline of molecular epidemiology of cancer. | Spitz MR | Carcinogenesis |
18385739 | A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. | Thorgeirsson TE | Nature |
18385738 | A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. | Hung RJ | Nature |
18618000 | A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction. | Weiss RB | PLoS Genet |
27698409 | Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele. | Oni EN | Sci Rep |
19896728 | Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25. | Bierut LJ | Trends Pharmacol Sci |
24339136 | Neurophysiologic effect of GWAS derived schizophrenia and bipolar risk variants. | Hall MH | Am J Med Genet B Neuropsychiatr Genet |
24296975 | Nicotine consumption is regulated by a human polymorphism in dopamine neurons. | Morel C | Mol Psychiatry |
22241830 | Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits. | Broms U | Nicotine Tob Res |
25941207 | An Adolescent Substance Prevention Model Blocks the Effect of CHRNA5 Genotype on Smoking During High School. | Vandenbergh DJ | Nicotine Tob Res |
25471942 | Contribution of Variants in CHRNA5/A3/B4 Gene Cluster on Chromosome 15 to Tobacco Smoking: From Genetic Association to Mechanism. | Wen L | Mol Neurobiol |
25474695 | Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers. | Taylor AE | PLoS Genet |
23404318 | Interpreting joint SNP analysis results: when are two distinct signals really two distinct signals? | Schwantes-An TH | Genet Epidemiol |
21856741 | Functional characterization of the alpha5(Asn398) variant associated with risk for nicotine dependence in the alpha3beta4alpha5 nicotinic receptor. | Li P | Mol Pharmacol |
20554942 | Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study. | Amos CI | J Natl Cancer Inst |
23024249 | Development of novel pharmacotherapeutics for tobacco dependence: progress and future directions. | Harmey D | Nicotine Tob Res |
22884254 | Association of nicotine dependence susceptibility gene, CHRNA5, with Parkinson's disease age at onset: gene and smoking status interaction. | Greenbaum L | Parkinsonism Relat Disord |
25911614 | Crucial role of nicotinic alpha5 subunit variants for Ca2+ fluxes in ventral midbrain neurons. | Sciaccaluga M | FASEB J |
20832656 | Genetics of addictions. | Hartz SM | Clin Lab Med |
25770649 | Are genetic variants for tobacco smoking associated with cannabis involvement? | Agrawal A | Drug Alcohol Depend |
21385908 | Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers. | Falcone M | Nicotine Tob Res |
27050379 | Genetic variants of CHRNA5-A3 and CHRNB3-A6 predict survival of patients with advanced non-small cell lung cancer. | Wang Y | Oncotarget |
20700147 | Nicotinic alpha5 receptor subunit mRNA expression is associated with distant 5' upstream polymorphisms. | Smith RM | Eur J Hum Genet |
27127891 | Association Between CHRNA3 and CHRNA5 Nicotine Receptor Subunit Gene Variants and Nicotine Dependence in an Isolated Populationof Kashubians in Poland. | Kita-Milczarska K | Med Sci Monit |
22012472 | Childhood adversity increases risk for nicotine dependence and interacts with alpha5 nicotinic acetylcholine receptor genotype specifically in males. | Xie P | Neuropsychopharmacology |
23565320 | DNA repair genotype and lung cancer risk in the beta-carotene and retinol efficacy trial. | Doherty JA | Int J Mol Epidemiol Genet |
23349013 | Genetic susceptibility to lung cancer--light at the end of the tunnel? | Marshall AL | Carcinogenesis |
22382757 | The CHRNA5/A3/B4 gene cluster and tobacco, alcohol, cannabis, inhalants and other substance use initiation: replication and new findings using mixture analyses. | Lubke GH | Behav Genet |
26948517 | Genetic scores of smoking behaviour in a Chinese population. | Yang S | Sci Rep |
22406075 | Association of single nucleotide polymorphisms of nicotinic acetylcholine receptor subunits with cervical neoplasia. | Calleja-Macias I | Life Sci |
21966413 | Smoking related cancers and loci at chromosomes 15q25, 5p15, 6p22.1 and 6p21.33 in the Polish population. | Jaworowska E | PLoS One |
20584212 | Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. | Saccone NL | Genes Brain Behav |
25073833 | Interplay of genetic risk (CHRNA5) and environmental risk (partner smoking) on cigarette smoking reduction. | Chen LS | Drug Alcohol Depend |
21685187 | Genome-wide association study of smoking behaviours in patients with COPD. | Siedlinski M | Thorax |
25072098 | Beyond cigarettes per day. A genome-wide association study of the biomarker carbon monoxide. | Bloom AJ | Ann Am Thorac Soc |
26831765 | Association between two CHRNA3 variants and susceptibility of lung cancer: a meta-analysis. | Qu X | Sci Rep |
19628476 | Association of serum cotinine level with a cluster of three nicotinic acetylcholine receptor genes (CHRNA3/CHRNA5/CHRNB4) on chromosome 15. | Keskitalo K | Hum Mol Genet |
23536134 | Polygenic risk and the developmental progression to heavy, persistent smoking and nicotine dependence: evidence from a 4-decade longitudinal study. | Belsky DW | JAMA Psychiatry |
19029397 | Nicotinic receptor gene variants influence susceptibility to heavy smoking. | Stevens VL | Cancer Epidemiol Biomarkers Prev |
27294413 | Human genome meeting 2016 : Houston, TX, USA. 28 February - 2 March 2016. | - | Hum Genomics |
23334941 | A bivariate mann-whitney approach for unraveling genetic variants and interactions contributing to comorbidity. | Wen Y | Genet Epidemiol |
24778978 | Genetics and smoking. | Loukola A | Curr Addict Rep |
25873736 | CHRNA5 risk variant predicts delayed smoking cessation and earlier lung cancer diagnosis--a meta-analysis. | Chen LS | J Natl Cancer Inst |
22276117 | The association between ATM IVS 22-77 T>C and cancer risk: a meta-analysis. | Zhao L | PLoS One |