rs17012484

Homo sapiens
A>C
None
Check p-value
SNV (Single Nucleotide Variation)
C=0131 (3904/29632,GnomAD)
C=0177 (5162/29118,TOPMED)
C=0181 (908/5008,1000G)
C=0036 (138/3854,ALSPAC)
C=0030 (110/3708,TWINSUK)
chr4:127520412 (GRCh38.p7) (4q28.1)
ND
GWASdb2
1   publication(s)
See rs on genome
4 Enhancers around
3 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 4NC_000004.12:g.127520412A>C
GRCh37.p13 chr 4NC_000004.11:g.128441567A>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.634C=0.366
1000GenomesAmericanSub694A=0.860C=0.140
1000GenomesEast AsianSub1008A=0.760C=0.240
1000GenomesEuropeSub1006A=0.969C=0.031
1000GenomesGlobalStudy-wide5008A=0.819C=0.181
1000GenomesSouth AsianSub978A=0.940C=0.060
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.964C=0.036
The Genome Aggregation DatabaseAfricanSub8600A=0.673C=0.327
The Genome Aggregation DatabaseAmericanSub832A=0.850C=0.150
The Genome Aggregation DatabaseEast AsianSub1592A=0.800C=0.200
The Genome Aggregation DatabaseEuropeSub18306A=0.965C=0.034
The Genome Aggregation DatabaseGlobalStudy-wide29632A=0.868C=0.131
The Genome Aggregation DatabaseOtherSub302A=0.960C=0.040
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.822C=0.177
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.970C=0.030
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs170124840.000366nicotine dependence17158188

eQTL of rs17012484 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs17012484 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr4128426043128426134E070-15433
chr4128426212128426760E081-14807
chr4128426799128426892E081-14675
chr4128426799128426892E082-14675



Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr4128459938128460233E06718371
chr4128459938128460233E06818371
chr4128459938128460233E07118371