rs17082721

Homo sapiens
G>A
LOC105376872 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0015 (473/29992,GnomAD)
A=0019 (566/29118,TOPMED)
A=0024 (118/5008,1000G)
A=0010 (40/3854,ALSPAC)
A=0013 (49/3708,TWINSUK)
chr18:70499885 (GRCh38.p7) (18q22.2)
ND
GWASdb2
1   publication(s)
See rs on genome
80 Enhancers around
9 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 18NC_000018.10:g.70499885G>A
GRCh37.p13 chr 18NC_000018.9:g.68167121G>A

Gene: LOC105376872, uncharacterized LOC105376872(plus strand)

Molecule type Change Amino acid[Codon] SO Term
LOC105376872 transcript variant X2XR_001753496.1:n.N/AIntron Variant
LOC105376872 transcript variant X1XR_935606.2:n.N/AGenic Downstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.970A=0.030
1000GenomesAmericanSub694G=0.990A=0.010
1000GenomesEast AsianSub1008G=0.953A=0.047
1000GenomesEuropeSub1006G=0.992A=0.008
1000GenomesGlobalStudy-wide5008G=0.976A=0.024
1000GenomesSouth AsianSub978G=0.990A=0.010
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.990A=0.010
The Genome Aggregation DatabaseAfricanSub8730G=0.968A=0.032
The Genome Aggregation DatabaseAmericanSub838G=0.990A=0.010
The Genome Aggregation DatabaseEast AsianSub1622G=0.969A=0.031
The Genome Aggregation DatabaseEuropeSub18500G=0.993A=0.006
The Genome Aggregation DatabaseGlobalStudy-wide29992G=0.984A=0.015
The Genome Aggregation DatabaseOtherSub302G=0.990A=0.010
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.980A=0.019
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.987A=0.013
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs170827210.000596nicotine dependence17158188

eQTL of rs17082721 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs17082721 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr186813042468130464E067-36657
chr186813051168130571E067-36550
chr186813155968131705E067-35416
chr186813172568131775E067-35346
chr186813178968131883E067-35238
chr186813622768136297E067-30824
chr186813650368136862E067-30259
chr186813701468137106E067-30015
chr186813711968137529E067-29592
chr186813756468137656E067-29465
chr186813042468130464E068-36657
chr186813051168130571E068-36550
chr186813155968131705E068-35416
chr186813172568131775E068-35346
chr186813178968131883E068-35238
chr186813622768136297E068-30824
chr186813650368136862E068-30259
chr186813701468137106E068-30015
chr186813622768136297E069-30824
chr186813650368136862E069-30259
chr186813701468137106E069-30015
chr186813711968137529E069-29592
chr186813756468137656E069-29465
chr186813711968137529E070-29592
chr186813756468137656E070-29465
chr186812188568122458E071-44663
chr186813042468130464E071-36657
chr186813051168130571E071-36550
chr186813148068131556E071-35565
chr186813155968131705E071-35416
chr186813172568131775E071-35346
chr186813178968131883E071-35238
chr186813622768136297E071-30824
chr186813650368136862E071-30259
chr186813701468137106E071-30015
chr186813711968137529E071-29592
chr186813756468137656E071-29465
chr186813148068131556E072-35565
chr186813155968131705E072-35416
chr186813172568131775E072-35346
chr186813178968131883E072-35238
chr186813622768136297E072-30824
chr186813650368136862E072-30259
chr186813701468137106E072-30015
chr186813711968137529E072-29592
chr186813042468130464E073-36657
chr186813051168130571E073-36550
chr186813155968131705E073-35416
chr186813172568131775E073-35346
chr186813178968131883E073-35238
chr186813650368136862E073-30259
chr186813701468137106E073-30015
chr186813711968137529E073-29592
chr186813756468137656E073-29465
chr186813042468130464E074-36657
chr186813051168130571E074-36550
chr186813155968131705E074-35416
chr186813172568131775E074-35346
chr186813178968131883E074-35238
chr186813622768136297E074-30824
chr186813650368136862E074-30259
chr186813701468137106E074-30015
chr186813711968137529E074-29592
chr186813756468137656E074-29465
chr186811726668118155E081-48966
chr186811821968118489E081-48632
chr186811850468118658E081-48463
chr186811938768119675E081-47446
chr186811991768119990E081-47131
chr186812134568121395E081-45726
chr186812188568122458E081-44663
chr186812265068122827E081-44294
chr186812291568122955E081-44166
chr186813172568131775E081-35346
chr186813178968131883E081-35238
chr186811726668118155E082-48966
chr186811821968118489E082-48632
chr186811850468118658E082-48463
chr186811868568118765E082-48356
chr186812291568122955E082-44166










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr186813197268132474E067-34647
chr186813197268132474E068-34647
chr186813197268132474E069-34647
chr186813197268132474E070-34647
chr186813197268132474E071-34647
chr186813197268132474E072-34647
chr186813197268132474E073-34647
chr186813197268132474E074-34647
chr186813197268132474E082-34647