rs17089358

Homo sapiens
T>C
SLC25A37 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0077 (2311/29988,GnomAD)
C=0101 (2951/29118,TOPMED)
C=0105 (526/5008,1000G)
C=0033 (129/3854,ALSPAC)
C=0036 (134/3708,TWINSUK)
chr8:23553762 (GRCh38.p7) (8p21.2)
AD
GWASdb2
2   publication(s)
See rs on genome
51 Enhancers around
19 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 8NC_000008.11:g.23553762T>C
GRCh37.p13 chr 8NC_000008.10:g.23411275T>C

Gene: SLC25A37, solute carrier family 25 member 37(plus strand)

Molecule type Change Amino acid[Codon] SO Term
SLC25A37 transcript variant 2NM_001317812.1:c.N/AIntron Variant
SLC25A37 transcript variant 3NM_001317813.1:c.N/AIntron Variant
SLC25A37 transcript variant 4NM_001317814.1:c.N/AIntron Variant
SLC25A37 transcript variant 1NM_016612.3:c.N/AIntron Variant
SLC25A37 transcript variant X1XM_011544550.2:c.N/AIntron Variant
SLC25A37 transcript variant X2XM_011544553.2:c.N/AIntron Variant
SLC25A37 transcript variant X5XM_011544554.2:c.N/AIntron Variant
SLC25A37 transcript variant X4XM_017013532.1:c.N/AIntron Variant
SLC25A37 transcript variant X3XM_006716352.3:c.N/AGenic Upstream Transcript Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.818C=0.182
1000GenomesAmericanSub694T=0.980C=0.020
1000GenomesEast AsianSub1008T=0.955C=0.045
1000GenomesEuropeSub1006T=0.978C=0.022
1000GenomesGlobalStudy-wide5008T=0.895C=0.105
1000GenomesSouth AsianSub978T=0.790C=0.210
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.967C=0.033
The Genome Aggregation DatabaseAfricanSub8726T=0.830C=0.170
The Genome Aggregation DatabaseAmericanSub838T=0.970C=0.030
The Genome Aggregation DatabaseEast AsianSub1620T=0.956C=0.044
The Genome Aggregation DatabaseEuropeSub18502T=0.961C=0.038
The Genome Aggregation DatabaseGlobalStudy-wide29988T=0.922C=0.077
The Genome Aggregation DatabaseOtherSub302T=0.940C=0.060
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.898C=0.101
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.964C=0.036
PMID Title Author Journal
21314694Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.Kendler KSAlcohol Clin Exp Res
23386860Exploring genome-wide - dietary heme iron intake interactions and the risk of type 2 diabetes.Pasquale LRFront Genet

P-Value

SNP ID p-value Traits Study
rs170893580.000688alcohol dependence21314694

eQTL of rs17089358 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs17089358 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr82338847623388546E067-22729
chr82338858023388636E067-22639
chr82338865123388707E067-22568
chr82338872123388798E067-22477
chr82338945523390455E067-20820
chr82338847623388546E068-22729
chr82338858023388636E068-22639
chr82338865123388707E068-22568
chr82338872123388798E068-22477
chr82338882523388908E068-22367
chr82338892723389009E068-22266
chr82338912723389196E068-22079
chr82338933623389454E068-21821
chr82338945523390455E068-20820
chr82339053823390623E068-20652
chr82339063923391366E068-19909
chr82339149823391578E068-19697
chr82339205223392112E068-19163
chr82339212023392175E068-19100
chr82339608323396915E068-14360
chr82339691923397164E068-14111
chr82339774923399828E068-11447
chr82341788323419068E0686608
chr82341908923419237E0687814
chr82338945523390455E069-20820
chr82339053823390623E069-20652
chr82339063923391366E069-19909
chr82338847623388546E070-22729
chr82338858023388636E070-22639
chr82338945523390455E070-20820
chr82339053823390623E070-20652
chr82339063923391366E070-19909
chr82339149823391578E070-19697
chr82339774923399828E070-11447
chr82338945523390455E071-20820
chr82339053823390623E071-20652
chr82339063923391366E071-19909
chr82341495623415053E0713681
chr82341509323415186E0713818
chr82341548623415583E0714211
chr82341562123415810E0714346
chr82341788323419068E0716608
chr82341908923419237E0717814
chr82338945523390455E072-20820
chr82339053823390623E072-20652
chr82339608323396915E072-14360
chr82339691923397164E072-14111
chr82339608323396915E073-14360
chr82339691923397164E073-14111
chr82341313623413228E0741861
chr82341324223413292E0741967








Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr82338065023381883E067-29392
chr82338491223388315E067-22960
chr82338065023381883E068-29392
chr82338491223388315E068-22960
chr82338065023381883E069-29392
chr82338491223388315E069-22960
chr82338065023381883E070-29392
chr82338491223388315E070-22960
chr82338065023381883E071-29392
chr82338491223388315E071-22960
chr82338065023381883E072-29392
chr82338491223388315E072-22960
chr82338065023381883E073-29392
chr82338491223388315E073-22960
chr82338065023381883E074-29392
chr82338491223388315E074-22960
chr82338491223388315E081-22960
chr82338065023381883E082-29392
chr82338491223388315E082-22960