rs17106558

Homo sapiens
G>A
ADCK1 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
A=0135 (4060/29970,GnomAD)
A=0125 (3652/29118,TOPMED)
A=0094 (473/5008,1000G)
A=0141 (545/3854,ALSPAC)
A=0141 (522/3708,TWINSUK)
chr14:77897589 (GRCh38.p7) (14q24.3)
AD
GWASdb2
1   publication(s)
See rs on genome
206 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 14NC_000014.9:g.77897589G>A
GRCh37.p13 chr 14NC_000014.8:g.78363932G>A

Gene: ADCK1, aarF domain containing kinase 1(plus strand)

Molecule type Change Amino acid[Codon] SO Term
ADCK1 transcript variant 2NM_001142545.1:c.N/AIntron Variant
ADCK1 transcript variant 1NM_020421.3:c.N/AIntron Variant
ADCK1 transcript variant X2XM_005267885.3:c.N/AIntron Variant
ADCK1 transcript variant X3XM_005267886.3:c.N/AIntron Variant
ADCK1 transcript variant X12XM_011536987.2:c.N/AIntron Variant
ADCK1 transcript variant X13XM_011536988.2:c.N/AIntron Variant
ADCK1 transcript variant X1XM_017021474.1:c.N/AIntron Variant
ADCK1 transcript variant X4XM_017021475.1:c.N/AIntron Variant
ADCK1 transcript variant X5XM_017021476.1:c.N/AIntron Variant
ADCK1 transcript variant X6XM_017021477.1:c.N/AIntron Variant
ADCK1 transcript variant X11XM_011536985.1:c.N/AGenic Upstream Transcript Variant
ADCK1 transcript variant X7XR_001750448.1:n.N/AIntron Variant
ADCK1 transcript variant X8XR_001750449.1:n.N/AIntron Variant
ADCK1 transcript variant X9XR_001750450.1:n.N/AIntron Variant
ADCK1 transcript variant X10XR_001750451.1:n.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.907A=0.093
1000GenomesAmericanSub694G=0.920A=0.080
1000GenomesEast AsianSub1008G=0.971A=0.029
1000GenomesEuropeSub1006G=0.841A=0.159
1000GenomesGlobalStudy-wide5008G=0.906A=0.094
1000GenomesSouth AsianSub978G=0.890A=0.110
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.859A=0.141
The Genome Aggregation DatabaseAfricanSub8724G=0.904A=0.096
The Genome Aggregation DatabaseAmericanSub838G=0.910A=0.090
The Genome Aggregation DatabaseEast AsianSub1618G=0.968A=0.032
The Genome Aggregation DatabaseEuropeSub18488G=0.836A=0.163
The Genome Aggregation DatabaseGlobalStudy-wide29970G=0.864A=0.135
The Genome Aggregation DatabaseOtherSub302G=0.780A=0.220
Trans-Omics for Precision MedicineGlobalStudy-wide29118G=0.874A=0.125
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.859A=0.141
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs171065580.00066alcohol dependence20201924

eQTL of rs17106558 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr14:78363932ADCK1ENSG00000063761.11G>A3.8823e-1597506Cerebellum
Chr14:78363932ADCK1ENSG00000063761.11G>A3.2510e-1097506Cerebellar_Hemisphere

meQTL of rs17106558 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr147834495978345031E067-18901
chr147834507278345112E067-18820
chr147834525578345311E067-18621
chr147834541178345461E067-18471
chr147834555278345612E067-18320
chr147834561478345682E067-18250
chr147834576178345856E067-18076
chr147834841678348858E067-15074
chr147834896578349361E067-14571
chr147834936678349473E067-14459
chr147834952378349810E067-14122
chr147834992578350077E067-13855
chr147835015378350203E067-13729
chr147835020578350257E067-13675
chr147835038678350461E067-13471
chr147835064478350723E067-13209
chr147837619978376281E06712267
chr147837635378376537E06712421
chr147837668678376750E06712754
chr147837683978377029E06712907
chr147832715578327215E068-36717
chr147832747778327802E068-36130
chr147832781878327939E068-35993
chr147832824578328305E068-35627
chr147832833078328443E068-35489
chr147832850478329119E068-34813
chr147834749778347704E068-16228
chr147834791978348027E068-15905
chr147834841678348858E068-15074
chr147834896578349361E068-14571
chr147834936678349473E068-14459
chr147834952378349810E068-14122
chr147834992578350077E068-13855
chr147835015378350203E068-13729
chr147835020578350257E068-13675
chr147835038678350461E068-13471
chr147837582578375896E06811893
chr147837619978376281E06812267
chr147837635378376537E06812421
chr147837668678376750E06812754
chr147834495978345031E069-18901
chr147834507278345112E069-18820
chr147834525578345311E069-18621
chr147834541178345461E069-18471
chr147834555278345612E069-18320
chr147834561478345682E069-18250
chr147834576178345856E069-18076
chr147834592378346127E069-17805
chr147834841678348858E069-15074
chr147834896578349361E069-14571
chr147834936678349473E069-14459
chr147834952378349810E069-14122
chr147834992578350077E069-13855
chr147835015378350203E069-13729
chr147835020578350257E069-13675
chr147835038678350461E069-13471
chr147835064478350723E069-13209
chr147837582578375896E06911893
chr147837619978376281E06912267
chr147837635378376537E06912421
chr147837668678376750E06912754
chr147837683978377029E06912907
chr147837708378377190E06913151
chr147833480078334850E070-29082
chr147833518578335516E070-28416
chr147833563578335675E070-28257
chr147833571878335773E070-28159
chr147833941578339669E070-24263
chr147833970578339745E070-24187
chr147834525578345311E070-18621
chr147834541178345461E070-18471
chr147834555278345612E070-18320
chr147834561478345682E070-18250
chr147834576178345856E070-18076
chr147834592378346127E070-17805
chr147834632578346382E070-17550
chr147834643878346705E070-17227
chr147834700578347072E070-16860
chr147834707578347204E070-16728
chr147834729978347339E070-16593
chr147834737778347427E070-16505
chr147834749778347704E070-16228
chr147834791978348027E070-15905
chr147834841678348858E070-15074
chr147834896578349361E070-14571
chr147834936678349473E070-14459
chr147834952378349810E070-14122
chr147834992578350077E070-13855
chr147835015378350203E070-13729
chr147835020578350257E070-13675
chr147835038678350461E070-13471
chr147836872978368823E0704797
chr147836893378369016E0705001
chr147836931778369421E0705385
chr147838871478388758E07024782
chr147832747778327802E071-36130
chr147832781878327939E071-35993
chr147832824578328305E071-35627
chr147832833078328443E071-35489
chr147832850478329119E071-34813
chr147834525578345311E071-18621
chr147834541178345461E071-18471
chr147834555278345612E071-18320
chr147834561478345682E071-18250
chr147834576178345856E071-18076
chr147834841678348858E071-15074
chr147834896578349361E071-14571
chr147834936678349473E071-14459
chr147834952378349810E071-14122
chr147834992578350077E071-13855
chr147835015378350203E071-13729
chr147835020578350257E071-13675
chr147835038678350461E071-13471
chr147835064478350723E071-13209
chr147835184478351966E071-11966
chr147835208678352166E071-11766
chr147835228278352332E071-11600
chr147835242378352473E071-11459
chr147835250978352572E071-11360
chr147837582578375896E07111893
chr147837619978376281E07112267
chr147837635378376537E07112421
chr147837668678376750E07112754
chr147837683978377029E07112907
chr147838456978384660E07120637
chr147838469878384801E07120766
chr147838495878385095E07121026
chr147832824578328305E072-35627
chr147832833078328443E072-35489
chr147832850478329119E072-34813
chr147834495978345031E072-18901
chr147834507278345112E072-18820
chr147834525578345311E072-18621
chr147834541178345461E072-18471
chr147834555278345612E072-18320
chr147834561478345682E072-18250
chr147834576178345856E072-18076
chr147834841678348858E072-15074
chr147834896578349361E072-14571
chr147834936678349473E072-14459
chr147834952378349810E072-14122
chr147834992578350077E072-13855
chr147835015378350203E072-13729
chr147835020578350257E072-13675
chr147835038678350461E072-13471
chr147835064478350723E072-13209
chr147837582578375896E07211893
chr147837619978376281E07212267
chr147837635378376537E07212421
chr147837668678376750E07212754
chr147832747778327802E073-36130
chr147832824578328305E073-35627
chr147832833078328443E073-35489
chr147832850478329119E073-34813
chr147834841678348858E073-15074
chr147834896578349361E073-14571
chr147834936678349473E073-14459
chr147834952378349810E073-14122
chr147834992578350077E073-13855
chr147835015378350203E073-13729
chr147835020578350257E073-13675
chr147835038678350461E073-13471
chr147837619978376281E07312267
chr147837635378376537E07312421
chr147837668678376750E07312754
chr147837683978377029E07312907
chr147832824578328305E074-35627
chr147832833078328443E074-35489
chr147832850478329119E074-34813
chr147834495978345031E074-18901
chr147834507278345112E074-18820
chr147834525578345311E074-18621
chr147834541178345461E074-18471
chr147834555278345612E074-18320
chr147834561478345682E074-18250
chr147834576178345856E074-18076
chr147834592378346127E074-17805
chr147834841678348858E074-15074
chr147834896578349361E074-14571
chr147834936678349473E074-14459
chr147834952378349810E074-14122
chr147834992578350077E074-13855
chr147835015378350203E074-13729
chr147835020578350257E074-13675
chr147835038678350461E074-13471
chr147835064478350723E074-13209
chr147835082078350860E074-13072
chr147835096378351013E074-12919
chr147837582578375896E07411893
chr147837619978376281E07412267
chr147837635378376537E07412421
chr147837668678376750E07412754
chr147837683978377029E07412907
chr147837708378377190E07413151
chr147834896578349361E081-14571
chr147834936678349473E081-14459
chr147834952378349810E081-14122
chr147834992578350077E081-13855
chr147835015378350203E081-13729
chr147835020578350257E081-13675
chr147835038678350461E081-13471
chr147836931778369421E0815385
chr147836963778370030E0815705
chr147834841678348858E082-15074
chr147834896578349361E082-14571
chr147834936678349473E082-14459