rs17149800

Homo sapiens
T>C
TMEM135 : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0103 (3096/29974,GnomAD)
C=0110 (3216/29118,TOPMED)
C=0084 (419/5008,1000G)
C=0107 (411/3854,ALSPAC)
C=0098 (364/3708,TWINSUK)
chr11:87184579 (GRCh38.p7) (11q14.2)
AD
GWASdb2
1   publication(s)
See rs on genome
18 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 11NC_000011.10:g.87184579T>C
GRCh37.p13 chr 11NC_000011.9:g.86895621T>C

Gene: TMEM135, transmembrane protein 135(plus strand)

Molecule type Change Amino acid[Codon] SO Term
TMEM135 transcript variant 2NM_001168724.1:c.N/AIntron Variant
TMEM135 transcript variant 1NM_022918.3:c.N/AIntron Variant
TMEM135 transcript variant 3NR_033149.1:n.N/AIntron Variant
TMEM135 transcript variant X1XM_017018140.1:c.N/AIntron Variant
TMEM135 transcript variant X2XM_017018141.1:c.N/AIntron Variant
TMEM135 transcript variant X2XM_017018142.1:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.876C=0.124
1000GenomesAmericanSub694T=0.930C=0.070
1000GenomesEast AsianSub1008T=0.943C=0.057
1000GenomesEuropeSub1006T=0.906C=0.094
1000GenomesGlobalStudy-wide5008T=0.916C=0.084
1000GenomesSouth AsianSub978T=0.940C=0.060
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.893C=0.107
The Genome Aggregation DatabaseAfricanSub8730T=0.883C=0.117
The Genome Aggregation DatabaseAmericanSub838T=0.950C=0.050
The Genome Aggregation DatabaseEast AsianSub1616T=0.933C=0.067
The Genome Aggregation DatabaseEuropeSub18488T=0.896C=0.103
The Genome Aggregation DatabaseGlobalStudy-wide29974T=0.896C=0.103
The Genome Aggregation DatabaseOtherSub302T=0.960C=0.040
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.889C=0.110
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.902C=0.098
PMID Title Author Journal
21703634A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.Wang KSJ Psychiatr Res

P-Value

SNP ID p-value Traits Study
rs171498009.25E-05alcohol dependence21703634

eQTL of rs17149800 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs17149800 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr118688415286884221E067-11400
chr118688425486884713E067-10908
chr118688482586884992E067-10629
chr118686671986866835E068-28786
chr118686687386867117E068-28504
chr118688415286884221E071-11400
chr118688425486884713E071-10908
chr118688482586884992E071-10629
chr118688507286885156E071-10465
chr118689895386899200E0713332
chr118686671986866835E074-28786
chr118686687386867117E074-28504
chr118688415286884221E074-11400
chr118688425486884713E074-10908
chr118688482586884992E074-10629
chr118689189186892084E074-3537
chr118689812686898547E0742505
chr118689895386899200E0743332