rs1736931

Homo sapiens
A>C / A>T
None
Check p-value
SNV (Single Nucleotide Variation)
A==0317 (9471/29820,GnomAD)
A==0293 (8556/29118,TOPMED)
A==0337 (1688/5008,1000G)
A==0284 (1093/3854,ALSPAC)
A==0278 (1032/3708,TWINSUK)
chr6:29710100 (GRCh38.p7) (6p22.1)
AD
GWASdb2
1   publication(s)
See rs on genome
0 Enhancer around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 6NC_000006.12:g.29710100A>C
GRCh38.p7 chr 6NC_000006.12:g.29710100A>T
GRCh37.p13 chr 6NC_000006.11:g.29677877A>C
GRCh37.p13 chr 6NC_000006.11:g.29677877A>T
GRCh38.p7 chr 6 alt locus HSCHR6_MHC_COX_CTG1NT_113891.3:g.1196613T>A
GRCh38.p7 chr 6 alt locus HSCHR6_MHC_COX_CTG1NT_113891.3:g.1196613T>C
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_COX_CTG1NT_113891.2:g.1196719T>A
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_COX_CTG1NT_113891.2:g.1196719T>C
GRCh38.p7 chr 6 alt locus HSCHR6_MHC_QBL_CTG1NT_167248.2:g.975586T>A
GRCh38.p7 chr 6 alt locus HSCHR6_MHC_QBL_CTG1NT_167248.2:g.975586T>C
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_QBL_CTG1NT_167248.1:g.981182T>A
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_QBL_CTG1NT_167248.1:g.981182T>C
GRCh38.p7 chr 6 alt locus HSCHR6_MHC_DBB_CTG1NT_167245.2:g.975631T>A
GRCh38.p7 chr 6 alt locus HSCHR6_MHC_DBB_CTG1NT_167245.2:g.975631T>C
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_DBB_CTG1NT_167245.1:g.981216T>A
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_DBB_CTG1NT_167245.1:g.981216T>C
GRCh38.p7 chr 6 alt locus HSCHR6_MHC_SSTO_CTG1NT_167249.2:g.1019137A>C
GRCh38.p7 chr 6 alt locus HSCHR6_MHC_SSTO_CTG1NT_167249.2:g.1019137A>T
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_SSTO_CTG1NT_167249.1:g.1018435A>C
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_SSTO_CTG1NT_167249.1:g.1018435A>T
GRCh38.p7 chr 6 alt locus HSCHR6_MHC_MANN_CTG1NT_167246.2:g.975200T>A
GRCh38.p7 chr 6 alt locus HSCHR6_MHC_MANN_CTG1NT_167246.2:g.975200T>C
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_MANN_CTG1NT_167246.1:g.980820T>A
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_MANN_CTG1NT_167246.1:g.980820T>C
GRCh38.p7 chr 6 alt locus HSCHR6_MHC_MCF_CTG1NT_167247.2:g.975446T>A
GRCh38.p7 chr 6 alt locus HSCHR6_MHC_MCF_CTG1NT_167247.2:g.975446T>C
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_MCF_CTG1NT_167247.1:g.981031T>A
GRCh37.p13 chr 6 alt locus HSCHR6_MHC_MCF_CTG1NT_167247.1:g.981031T>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322A=0.334T=0.666
1000GenomesAmericanSub694A=0.300T=0.700
1000GenomesEast AsianSub1008A=0.350T=0.650
1000GenomesEuropeSub1006A=0.315T=0.685
1000GenomesGlobalStudy-wide5008A=0.337T=0.663
1000GenomesSouth AsianSub978A=0.370T=0.630
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854A=0.284T=0.716
The Genome Aggregation DatabaseAfricanSub8682A=0.318T=0.682
The Genome Aggregation DatabaseAmericanSub836A=0.280T=0.72,
The Genome Aggregation DatabaseEast AsianSub1602A=0.340T=0.660
The Genome Aggregation DatabaseEuropeSub18400A=0.317T=0.682
The Genome Aggregation DatabaseGlobalStudy-wide29820A=0.317T=0.682
The Genome Aggregation DatabaseOtherSub300A=0.300T=0.70,
Trans-Omics for Precision MedicineGlobalStudy-wide29118A=0.293T=0.706
UK 10K study - TwinsTWIN COHORTStudy-wide3708A=0.278T=0.722
PMID Title Author Journal
20201924Genome-wide association study of alcohol dependence implicates a region on chromosome 11.Edenberg HJAlcohol Clin Exp Res

P-Value

SNP ID p-value Traits Study
rs17369310.000736alcohol dependence20201924

eQTL of rs1736931 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
Chr6:29677877RPL23AP1ENSG00000239257.1A>T3.1209e-7-16782Cerebellum
Chr6:29677877MICEENSG00000273340.1A>T7.2793e-10-35134Cerebellum
Chr6:29677877HLA-F-AS1ENSG00000214922.5A>T8.4756e-13-38893Cerebellum
Chr6:29677877MICEENSG00000273340.1A>T2.3222e-6-35134Cerebellar_Hemisphere
Chr6:29677877HLA-F-AS1ENSG00000214922.5A>T2.4717e-9-38893Cerebellar_Hemisphere
Chr6:29677877HLA-HENSG00000206341.6A>T2.5783e-22-178367Cerebellar_Hemisphere
Chr6:29677877HLA-HENSG00000206341.6A>T5.2793e-5-178367Caudate_basal_ganglia
Chr6:29677877HLA-KENSG00000230795.2A>T3.1711e-10-217078Hippocampus
Chr6:29677877HLA-KENSG00000230795.2A>T9.2361e-15-217078Nucleus_accumbens_basal_ganglia

meQTL of rs1736931 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.