rs17435204

Homo sapiens
T>A / T>C
ARL8A : Intron Variant
Check p-value
SNV (Single Nucleotide Variation)
C=0017 (522/29960,GnomAD)
C=0011 (347/29118,TOPMED)
C=0008 (38/5008,1000G)
C=0020 (79/3854,ALSPAC)
C=0022 (80/3708,TWINSUK)
chr1:202137868 (GRCh38.p7) (1q32.1)
ND
GWASdb2
1   publication(s)
See rs on genome
10 Enhancers around
46 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 1NC_000001.11:g.202137868T>A
GRCh38.p7 chr 1NC_000001.11:g.202137868T>C
GRCh37.p13 chr 1NC_000001.10:g.202106996T>A
GRCh37.p13 chr 1NC_000001.10:g.202106996T>C

Gene: ARL8A, ADP ribosylation factor like GTPase 8A(minus strand)

Molecule type Change Amino acid[Codon] SO Term
ARL8A transcript variant 2NM_001256129.1:c.N/AIntron Variant
ARL8A transcript variant 1NM_138795.3:c.N/AIntron Variant

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322T=0.999C=0.001
1000GenomesAmericanSub694T=0.990C=0.010
1000GenomesEast AsianSub1008T=1.000C=0.000
1000GenomesEuropeSub1006T=0.974C=0.026
1000GenomesGlobalStudy-wide5008T=0.992C=0.008
1000GenomesSouth AsianSub978T=1.000C=0.000
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854T=0.980C=0.020
The Genome Aggregation DatabaseAfricanSub8724T=0.996C=0.004
The Genome Aggregation DatabaseAmericanSub838T=0.980C=0.020
The Genome Aggregation DatabaseEast AsianSub1622T=1.000C=0.000
The Genome Aggregation DatabaseEuropeSub18474T=0.974C=0.025
The Genome Aggregation DatabaseGlobalStudy-wide29960T=0.982C=0.017
The Genome Aggregation DatabaseOtherSub302T=0.980C=0.020
Trans-Omics for Precision MedicineGlobalStudy-wide29118T=0.988C=0.011
UK 10K study - TwinsTWIN COHORTStudy-wide3708T=0.978C=0.022
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs174352040.000267nicotine dependence17158188

eQTL of rs17435204 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs17435204 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr13549532135495393E067-25084
chr13549552235495612E067-24865
chr13549532135495393E068-25084
chr13549552235495612E068-24865
chr13549489635494986E071-25491
chr13549532135495393E071-25084
chr13549532135495393E072-25084
chr13549552235495612E072-24865
chr13549552235495612E074-24865
chr13549552235495612E081-24865






Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr13549635435497723E067-22754
chr13549775335497810E067-22667
chr13549789735497971E067-22506
chr13554451335545502E06724036
chr13554572035545888E06725243
chr13549635435497723E068-22754
chr13549775335497810E068-22667
chr13549789735497971E068-22506
chr13554451335545502E06824036
chr13554572035545888E06825243
chr13549635435497723E069-22754
chr13549775335497810E069-22667
chr13549789735497971E069-22506
chr13554451335545502E06924036
chr13554572035545888E06925243
chr13549635435497723E070-22754
chr13549775335497810E070-22667
chr13549789735497971E070-22506
chr13554451335545502E07024036
chr13554572035545888E07025243
chr13549635435497723E071-22754
chr13549775335497810E071-22667
chr13549789735497971E071-22506
chr13554451335545502E07124036
chr13554572035545888E07125243
chr13549635435497723E072-22754
chr13549775335497810E072-22667
chr13549789735497971E072-22506
chr13554451335545502E07224036
chr13554572035545888E07225243
chr13549635435497723E073-22754
chr13549775335497810E073-22667
chr13549789735497971E073-22506
chr13554451335545502E07324036
chr13554572035545888E07325243
chr13549635435497723E074-22754
chr13549775335497810E074-22667
chr13549789735497971E074-22506
chr13554451335545502E07424036
chr13554572035545888E07425243
chr13554451335545502E08124036
chr13554572035545888E08125243
chr13549635435497723E082-22754
chr13549775335497810E082-22667
chr13554451335545502E08224036
chr13554572035545888E08225243