rs17577580

Homo sapiens
C>T
None
Check p-value
SNV (Single Nucleotide Variation)
T=0150 (4499/29872,GnomAD)
T=0126 (3678/29118,TOPMED)
T=0105 (524/5008,1000G)
T=0170 (657/3854,ALSPAC)
T=0165 (611/3708,TWINSUK)
chr14:100722868 (GRCh38.p7) (14q32.2)
AD
GWASdb2
1   publication(s)
See rs on genome
63 Enhancers around
3 Promoters around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 14NC_000014.9:g.100722868C>T
GRCh37.p13 chr 14NC_000014.8:g.101189205C>T
DLK1 RefSeqGeneNG_016863.2:g.1004C>T

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322C=0.933T=0.067
1000GenomesAmericanSub694C=0.900T=0.100
1000GenomesEast AsianSub1008C=0.972T=0.028
1000GenomesEuropeSub1006C=0.819T=0.181
1000GenomesGlobalStudy-wide5008C=0.895T=0.105
1000GenomesSouth AsianSub978C=0.840T=0.160
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854C=0.830T=0.170
The Genome Aggregation DatabaseAfricanSub8710C=0.926T=0.074
The Genome Aggregation DatabaseAmericanSub834C=0.870T=0.130
The Genome Aggregation DatabaseEast AsianSub1618C=0.962T=0.038
The Genome Aggregation DatabaseEuropeSub18408C=0.803T=0.196
The Genome Aggregation DatabaseGlobalStudy-wide29872C=0.849T=0.150
The Genome Aggregation DatabaseOtherSub302C=0.780T=0.220
Trans-Omics for Precision MedicineGlobalStudy-wide29118C=0.873T=0.126
UK 10K study - TwinsTWIN COHORTStudy-wide3708C=0.835T=0.165
PMID Title Author Journal
23743675A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.Kapoor MHum Genet

P-Value

SNP ID p-value Traits Study
rs175775801E-05alcohol consumption23743675

eQTL of rs17577580 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs17577580 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr14101143469101145416E067-43789
chr14101143469101145416E068-43789
chr14101155277101155575E068-33630
chr14101155589101155778E068-33427
chr14101143469101145416E069-43789
chr14101139272101140350E070-48855
chr14101140429101140699E070-48506
chr14101142121101142353E070-46852
chr14101142407101143045E070-46160
chr14101143057101143223E070-45982
chr14101143469101145416E070-43789
chr14101145433101145524E070-43681
chr14101145569101145666E070-43539
chr14101145798101145872E070-43333
chr14101154589101154674E070-34531
chr14101157358101157478E070-31727
chr14101157651101157701E070-31504
chr14101157816101158038E070-31167
chr14101158059101158763E070-30442
chr14101196747101196834E0707542
chr14101197075101197184E0707870
chr14101197193101197372E0707988
chr14101198422101198592E0709217
chr14101198754101199236E0709549
chr14101199336101199386E07010131
chr14101199419101199477E07010214
chr14101199514101199830E07010309
chr14101216945101216995E07027740
chr14101217318101217368E07028113
chr14101217423101217496E07028218
chr14101217864101217952E07028659
chr14101218288101218602E07029083
chr14101219120101219170E07029915
chr14101231086101231503E07041881
chr14101231582101231640E07042377
chr14101231753101231814E07042548
chr14101231933101231977E07042728
chr14101143057101143223E071-45982
chr14101162904101163586E071-25619
chr14101143469101145416E072-43789
chr14101143469101145416E073-43789
chr14101143469101145416E074-43789
chr14101139272101140350E081-48855
chr14101141580101141896E081-47309
chr14101143057101143223E081-45982
chr14101143469101145416E081-43789
chr14101154984101155227E081-33978
chr14101155277101155575E081-33630
chr14101155589101155778E081-33427
chr14101157816101158038E081-31167
chr14101162104101162808E081-26397
chr14101162904101163586E081-25619
chr14101139272101140350E082-48855
chr14101143469101145416E082-43789
chr14101189200101189255E0820
chr14101189368101189418E082163
chr14101189420101189460E082215
chr14101189603101190047E082398
chr14101192164101192223E0822959
chr14101192244101192551E0823039
chr14101196747101196834E0827542
chr14101197075101197184E0827870
chr14101197193101197372E0827988










Promoter Annotation (GRCh37.p13)

Chromosome Start End Region Distance(-/+:Up/Downstream)
chr14101192825101193516E0703620
chr14101192633101192820E0823428
chr14101192825101193516E0823620