rs17627328

Homo sapiens
G>A / G>C
None
Check p-value
SNV (Single Nucleotide Variation)
A=0288 (8597/29762,GnomAD)
A=0215 (1078/5008,1000G)
A=0304 (1172/3854,ALSPAC)
A=0318 (1178/3708,TWINSUK)
chr17:12284988 (GRCh38.p7) (17p12)
ND
GWASdb2
1   publication(s)
See rs on genome
35 Enhancers around
0 Promoter around

Genomic Coordinates

Sequence Name Change(s)
GRCh38.p7 chr 17NC_000017.11:g.12284988G>A
GRCh38.p7 chr 17NC_000017.11:g.12284988G>C
GRCh37.p13 chr 17NC_000017.10:g.12188305G>A
GRCh37.p13 chr 17NC_000017.10:g.12188305G>C

Population Frequency

Study Population Group Sample # Ref Allele Alt Allele
1000GenomesAfricanSub1322G=0.787A=0.213
1000GenomesAmericanSub694G=0.780A=0.220
1000GenomesEast AsianSub1008G=0.871A=0.129
1000GenomesEuropeSub1006G=0.706A=0.294
1000GenomesGlobalStudy-wide5008G=0.785A=0.215
1000GenomesSouth AsianSub978G=0.780A=0.220
The Avon Longitudinal Study of Parents and ChildrenPARENT AND CHILD COHORTStudy-wide3854G=0.696A=0.304
The Genome Aggregation DatabaseAfricanSub8682G=0.762C=0.000
The Genome Aggregation DatabaseAmericanSub836G=0.790C=0.00,
The Genome Aggregation DatabaseEast AsianSub1620G=0.858C=0.000
The Genome Aggregation DatabaseEuropeSub18324G=0.671C=0.000
The Genome Aggregation DatabaseGlobalStudy-wide29762G=0.711C=0.000
The Genome Aggregation DatabaseOtherSub300G=0.640C=0.00,
UK 10K study - TwinsTWIN COHORTStudy-wide3708G=0.682A=0.318
PMID Title Author Journal
17158188Novel genes identified in a high-density genome wide association study for nicotine dependence.Bierut LJHum Mol Genet

P-Value

SNP ID p-value Traits Study
rs176273280.000418nicotine dependence17158188

eQTL of rs17627328 in Brain tissues (GTEx Analysis Release V7)

Position (v37) eGene GeneID Variant p-value TSS Tissue
There is no eQTL annotation for this SNP

meQTL of rs17627328 in Fetal Brain

Probe ID Position Gene beta p-value
There is no meQTL annotation for this SNP

Genomic View

Chromatin Interaction

There is no significant Hi-C chromatin interaction data for this SNP.

Enhancer Annotation (GRCh37.p13)

Chromosome Start End Region Distance ( -/+ : Up/Downstream )
chr171135660811356701E070-26646
chr171136010211360180E070-23167
chr171136023311360365E070-22982
chr171136257311362682E070-20665
chr171136308911363610E070-19737
chr171138887611389063E0705529
chr171138909211389794E0705745
chr171138984811390303E0706501
chr171139044211390565E0707095
chr171139058611390636E0707239
chr171139724511397689E07013898
chr171139896311399260E07015616
chr171136308911363610E073-19737
chr171138887611389063E0815529
chr171138909211389794E0815745
chr171138984811390303E0816501
chr171139044211390565E0817095
chr171139058611390636E0817239
chr171139341411393531E08110067
chr171139358411393951E08110237
chr171139398911394202E08110642
chr171139676811396821E08113421
chr171139694711397105E08113600
chr171139711511397158E08113768
chr171139724511397689E08113898
chr171139896311399260E08115616
chr171136010211360180E082-23167
chr171136023311360365E082-22982
chr171138887611389063E0825529
chr171138909211389794E0825745
chr171138984811390303E0826501
chr171139044211390565E0827095
chr171139058611390636E0827239
chr171139724511397689E08213898
chr171139896311399260E08215616